How do proteins find their way to the cell's leading edge? @jimgalbraith27.bsky.social & @cathygalbraith.bsky.social break down how bleach line, FLOP, single-particle tracking, FCS & iPALM reveal intracellular fluid flow and an actin-myosin compartment barrier. doi.org/10.1038/s414...
I'm happy to share a recent study by @cathygalbraith.bsky.social & James Galbraith, along with @sciencethecat.bsky.social & myself. It challenges existing views onΒ intracellular transportationβ¦ π www.nature.com/articles/s41...
What if cells have undiscovered methods for managing their internal logistics? Our recent work (@cathygalbraith.bsky.social, James A. Galbraith, @sciencethecat.bsky.social & myself) challenges existing views on intracellular transportation π lnkd.in/dhMDgY5Q
So excited to share this work that employs #FCS, TIRF, FRAP, SPT, SIM & #iPALM. Huge thanks to @cathygalbraith.bsky.social, James Galbraith, and @ulrikeboehm.bsky.social (the iPALM wizard) #OpenScience @hhmijanelia.bsky.social #CellBiology #Cytoskeleton #SuperResolution #Microscopy #Actin
Delighted to share our preprint describing COMET, a new approach to drift correction for #SMLM, which performs exceptionally well in practice. Check out the benchmarking results compared to other methods! :) Thanks to @lreinkensmeier.bsky.social for a superb effort.
www.biorxiv.org/cgi/content/...
Max Planck Center for Physics and Medicine building
Max Planck Instittute for the Science of Light building
π¨New Lab Alert!π¨ Superhappy to announce that I will start my lab combining photonics & neuroscience at the Max Planck Center for Physics & Medicine in Erlangen & @mpi-scienceoflight.bsky.social in January 2027! Reach out if you're interested in internships, BSc, MSc & PhD & postdoc projects!
A high-affinity split-HaloTag for live-cell protein labeling. And much more.
www.nature.com/articles/s41...
Cloud of words in various colors and sizes on a white background, arranged in the shape of a rectangle. Some of the largest words include cell imaging single living dynamic molecules tracking microscopy single-molecule translation complex michaelis-menten protein reveals RNA super-resolution accessible bacterial coronavirus eif4f enzyme equation fluorescent fluorophores general hcov-oc43 individual inhibition live molecule
Cloud of words in various colors and sizes on a black background, arranged in the shape of a rectangle. Some of the largest words include cell imaging single living dynamic molecules tracking microscopy single-molecule translation complex michaelis-menten protein reveals RNA super-resolution accessible bacterial coronavirus eif4f enzyme equation fluorescent fluorophores general hcov-oc43 individual inhibition live molecule
Cloud of words in various colors and sizes on a white background, arranged in the shape of a rectangle. Some of the largest words include cell imaging single living dynamic molecules tracking microscopy single-molecule translation complex michaelis-menten protein reveals RNA super-resolution accessible bacterial coronavirus eif4f enzyme equation fluorescent fluorophores general hcov-oc43 individual inhibition live molecule
Brian Patrick English loves writing about cell, imaging, single, living, dynamic, molecules and probably posts about them here too @sciencethecat.bsky.social
Create yours at https://scholargoggler.com/
And in yesterday's journal club, we discussed this nice paper on transforming antibodies into intrabodies from @tim-stasevich.bsky.social et al. The authors put together a pipeline comprising ProteinMPNN to design a stabler protein sequence for the scaffold while keeping the antigen-binding loops.
Fluorescent dyes at the Lavis Lab at Janelia Research Campus
Beautiful, & built for discovery. These next-gen fluorescent dyes (developed by the Lavis Lab at our Janelia Research Campus) are brighter, more photostable, & more versatile β advancing how scientists visualize biology inside cells.
Pi-day opening at Cultivate Gallery: Heloisa's DIScomfort Beauty interactive installation @heloisarts.bsky.social #washingtondc #interactiveart #videoinstallation @cultivateprojects.bsky.social
This Saturday: art by my β₯οΈ Heloisa!
ππ π°πΆππΆπ»π΄ ππ²ππ²πΉπΌπ½πΊπ²π»ππ πΆπ» π πΆπ°πΏπΌππ°πΌπ½π π₯π²π½πΌπΏππΆπ»π΄! If you're involved in creating, processing, or publishing microscopy data, take a look at the new checklist for reporting requirements provided by @quarep-limi.bsky.social in @jcb.org π rupress.org/jcb/article/...
As a lifelong Bayern fan, I feel incredibly lucky to have a coach with this much class leading our team.
Bayern Munich head coach Vincent Kompany has said Jose Mourinho made a βhuge mistakeβ in accusing Vinicius Junior of inciting an incident that ended with the Real Madrid forward alleging racist abuse.
More from @sebsb.bsky.social and @colinmillar.bsky.social
www.nytimes.com/athletic/705...
Brasil sil sil sil
Lucas gets gold.
Bagunca Brasileiro
In @elife.bsky.social: A high-resolution, easy-to-build light-sheet microscope for subcellular imaging doi.org/10.7554/eLif...
What an amazing opportunity to work on cutting edge biology and biophysics with a great mentor. Apply!!!!
Unquestionably the result of combined effort from all current and former lab members, support from colleagues @CSU and @CU, and support from @hhmi-science.bsky.social and NIH over decades. A heartfelt π to my nominators and of course @vilcekfoundation.bsky.social.
vilcek.org/prizes/prize...
on Holocaust Remembrance Day
Time by Luxmuralis at the Washington National Cathedral
Having grown up in a small Bavarian farming village of 600 people, itβs incredibly rewarding to finally be properly recognized. #Grassland #Pasture #MiaSanMia #MDPI
2025 "dumpster fire" gingerbread house made for the holiday season.
Gingerbread 2025 Dumpster π₯
Janelia is hiring! "Invent new imaging methods, molecular tools, or protein chemistry approaches"
www.janelia.org/content/lead...
Today I departed from @hhmijanelia.bsky.social knowing that the next time I come here, I will be a visitor.
Thank you all for having me. I will miss you a lot.
Holiday party 2025 @hhmijanelia.bsky.social
Day 2 also covers Fourier Optics, with a fantastic lecture from Dr. Peter Kner! You'll never understand Fourier transforms better than you do after Peter explains it, trust us.
Apply now to join us and finally understand #Fourier space! bit.ly/49YQl7q
#microscopy
The Company of Biologists 100 logo to the left and QR code to the right. Portrait of Jennifer Waters to the left, text to the right 100 extraordinary biologists Jennifer Waters Jennifer Waters, a FocalPlane Scientific Advisory Board member, is the Director of Core for Imaging Technology & Education, Harvard Medical School, USA. She created MicroList and draws on over 25 years of teaching experience to create accessible microscopy education resources, including the online platform Microtutor. #100biologists #biologists100
We are highlighting Jennifer Waters, a @focalplane.bsky.social Scientific Advisory Board member, Director of CITE, Harvard Medical School, and creator of MicroList (now featured in FocalPlane) and Microtutor, as an extraordinary biologist. #100biologists
@jencwaters.bsky.social
Attempt number seven at uploading this video of intermediate filaments in an enormous COS7 cell. I have a feeling the BlueSky compression will not do it any favors.
We are happy to share our latest work, 4Pi-SIMFLUX, which combines structured illumination with interferometric detection to achieve near-isotropic 3D localization precision of 2β3 nm and resolve sub-10 nm structural features across whole mammalian cells.
www.nature.com/articles/s41...
rdcu.be/eQVxt
