Brain organoids are a transformative technology — but they need regulation The potential benefits of organoids for fundamental research and medicine are huge. Efforts to establish proper boundaries for their use should be supported.

The potential benefits of organoids for fundamental research and medicine are huge. Efforts to establish proper boundaries for their use should be supported

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Active dissociation of intracortical spiking and high gamma activity - Nature A brain–machine interface is used in monkeys to investigate the biophysical underpinnings of cortical high gamma-band activity, a signal that is often studied in the context of many brain functions.

Nature research paper: Active dissociation of intracortical spiking and high gamma activity

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Mini models of the human brain are revealing how this complex organ takes shape Lab-grown organoids are turbo-charging the study of human brain development and disease.

Lab-grown organoids are turbo-charging the study of human brain development and disease

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When career anxiety becomes gameplay: lessons from China’s ‘young-faculty simulator’ A popular online game simulates life as an academic — and throws the challenges of being an early-career researcher into sharp relief.

A popular online game simulates life as an academic — and throws the challenges of being an early-career researcher into sharp relief

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New drugs take aim at one of cancer’s deadliest mutations Mutations in the KRAS protein were once deemed ‘undruggable’. Today, various approaches are in the pipeline.

Researchers are closing in on innovative strategies to undermine a cancer-causing mutant protein once considered to be ‘undruggable’

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Hydroxy-induced cobalt oxides for syngas to light olefins - Nature A set of hydroxy promoters physically mixed with cobalt oxides for syngas to light olefins conversion using Fischer–Tropsch synthesis is shown to boost catalyst performance as well as simplifying the process and increasing sustainability.

Nature research paper: Hydroxy-induced cobalt oxides for syngas to light olefins

go.nature.com/4sb7Rem

First photos from Artemis II: see stunning 'Earthset' and more Images snapped during a flyby capture a solar eclipse and unprecedented details of the far side of the Moon.

Breathtaking photos are coming down to Earth from NASA’s historic Artemis II mission, after its four astronauts flew around the far side of the Moon yesterday. Prepare to be dazzled.

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Deconstruction of a spino-brain–spinal cord circuit that drives chronic pain - Nature In mice, a circuit between the spinal cord and various regions of the brain, centring on spinal-cord-projecting neurons in the rostral ventromedial medulla, has a key role in driving chronic pain.

Nature research paper: Deconstruction of a spino-brain–spinal cord circuit that drives chronic pain

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Your brain on drugs: different psychedelics work in surprisingly similar ways Hundreds of scans hint at how substances such as psilocybin, LSD and ayahuasca alter connections between key areas of the brain.

Hundreds of scans hint at how substances such as psilocybin, LSD and ayahuasca alter connections between key areas of the brain

go.nature.com/3QamxwN

Moon fly-by live coverage: Artemis crew emerge from behind the Moon, see Earth ‘rising’ Astronauts are flying by the Moon’s far side and setting records. Nature is in Houston with the mission’s scientists.

Did you miss the Artemis II flyby last night? Catch up with our coverage of the historic event, as it happened

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Scientists invented a fake disease. AI told people it was real Bixonimania doesn’t exist except in a clutch of obviously bogus academic papers. So why did AI chatbots warn people about this fictional illness?

This researcher created a fictional illness, and fake studies funded by the Professor Sideshow Bob Foundation and University of the Fellowship of the Ring and the Galactic Triad.

LLMs warned people the illness was real.

go.nature.com/48mAyh9

‘Yes, we can’: a blueprint for a clean economy and healthy society As oil and gas markets face crisis, an influential economist sets out a path to a more efficient, prosperous and sustainable world.

Book review 📚 ‘Yes, we can’: a blueprint for a clean economy and healthy society

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‘Net zero’ isn’t madness: the staggering economic costs of climate change The landmark Stern Review, published 20 years ago, laid bare the economic cost of climate inaction. A fracturing political consensus now risks accruing even heftier bills for future generations.

A fracturing political landscape and climate inaction is risking cumulative economic costs for future generations

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How DNA forensics is transforming studies of ancient manuscripts Scientists are exposing the biological information hidden in ancient parchments without leaving a mark.

Scientists are exposing the biological information hidden in ancient parchments without leaving a mark

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An enteric neuron ionotropic receptor regulates salt stress resistance - Nature The I3 pharyngeal enteric neuron in Caenorhabditis elegans detects high-salt conditions, and the GLR-9 ionotropic salt receptor expressed specifically in I3 regulates genes related to salt stress resistance in distal tissues.

Nature research paper: An enteric neuron ionotropic receptor regulates salt stress resistance

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Engaging the head and the heart: why scientists turn to poetry Some researchers use verse to visualize complex problems or translate the wonders of science for wider audiences.

Some researchers use verse to visualize complex problems or translate the wonders of science for wider audiences

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This method to reverse cellular ageing is about to be tested in humans A burgeoning field is launching its first clinical trial to find out whether dialling back cell development can safely refresh aged tissues and organs.

Can dialling back cell development safely refresh aged tissues and organs?

go.nature.com/4bUNPQl

A chelicera-bearing arthropod reveals the Cambrian origin of chelicerates - Nature Megachelicerax cousteaui gen. et sp. nov. is a large soft-bodied arthropod from the middle Cambrian of Utah featuring massive three-segmented chelicerae, along with five pairs of pseudobiramous prosomal limbs with non-foliaceous exopodal rami, and plate-like lamellae-bearing opisthosomal appendages.

Nature research paper: A chelicera-bearing arthropod reveals the Cambrian origin of chelicerates
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Super-potent opioids could be safer-than-expected alternatives to conventional painkillers Modified nitazenes, opioids 1,000 times stronger than morphine, show remarkably few adverse effects in rodents, renewing the potential of these drugs for pain relief.

Modified nitazenes, opioids 1,000 times stronger than morphine, show remarkably few adverse effects in rodents, renewing the potential of these drugs for pain relief

go.nature.com/4m54mo1

Dual-symmetry-guided assembly of complex lattices - Nature A dual-symmetry-guided strategy is used to assemble a broad class of complex Archimedean lattices and two-dimensional quasicrystalline structures, providing a general and experimentally accessible route to complex-symmetry materials.

Nature research paper: Dual-symmetry-guided assembly of complex lattices

go.nature.com/4sVWJ67

Artemis II astronauts fly by the Moon today: follow along with Nature live Humans are seeing parts of the Moon’s far side never observed by eye. Nature is in Houston with the mission’s scientists.

For the Artemis astronauts, the Sun has will be hidden by the Moon for the next hour

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Artemis II astronauts fly by the Moon today: follow along with Nature live Humans are seeing parts of the Moon’s far side never observed by eye. Nature is in Houston with the mission’s scientists.

This is the first time in more than 50 years that humans have been completely unreachable

Follow along with our live blog for Artemis II mission updates

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Artemis II astronauts fly by the Moon today: follow along with Nature live Humans are seeing parts of the Moon’s far side never observed by eye. Nature is in Houston with the mission’s scientists.

“'Full Moon Joy' is becoming somewhat of a catchphrase of this mission"

Follow our live blog to keep up with the action of the Artemis II fly-by of the Moon
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Follow along with us at @nature.com as we bring you today’s #ArtemisII lunar flyby - straight from mission scientists at Mission Control in Houston. I’ll have live updates throughout the day on this historic Moon mission. 🧪🔭

www.nature.com/articles/d41...

Artemis II astronauts fly by the Moon today: follow along with Nature live Humans are seeing parts of the Moon’s far side never observed by eye. Nature is in Houston with the mission’s scientists.

LIVE: Artemis astronauts set record for distance travelled from Earth by humans

Alexandra Witze is in Houston, follow our live blog for updates of the Moon fly-by 🌔

go.nature.com/41VFR3n

Evolution of pandemic cholera at its global source - Nature The seventh cholera pandemic, driven by El Tor Vibrio cholerae, evolved separately in Bangladesh and India, with the Ganges Basin acting as the global source, and its evolution has been shaped by phage defence system changes, influencing severity and transmission.

Nature research paper: Evolution of pandemic cholera at its global source

go.nature.com/41HXkMG

Flexible ensheathment of axons enables myelination of complex CNS networks - Nature The rate of axon ensheathment varies within individual myelinating processes, resulting in chains of myelin sheaths connected by bridges consisting of thin cytoplasmic processes that provide flexibility for myelination of highly branched axons.

Nature research paper: Flexible ensheathment of axons enables myelination of complex CNS networks

go.nature.com/3QcuTUy

Artemis II astronauts fly by the Moon today: follow along with Nature live Humans are seeing parts of the Moon’s far side never observed by eye. Nature is in Houston with the mission’s scientists.

Astronauts return to the Moon today for the first time in more than 50 years! Nature correspondent Alexandra Witze is sitting with mission scientists in Houston as they advise the crew. Join us live.

go.nature.com/4c9W3Ts

Angle evolution of the superconducting phase diagram in twisted bilayer WSe2 - Nature Superconductivity in twisted bilayer WSe2 evolves smoothly with twist angle and emerges near Fermi surface reconstruction, linking previously distinct phase diagrams and clarifying its correlated origin.

Nature research paper: Angle evolution of the superconducting phase diagram in twisted bilayer WSe2

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Catalyst diverts course of industrial process to make valuable hydrocarbons A catalyst with two cobalt components potentially opens the way to sustainable processes for manufacturing light olefins — key ingredients for making plastics and detergents.

A catalyst with two cobalt components potentially opens the way to sustainable processes for manufacturing light olefins — key ingredients for making plastics and detergents

go.nature.com/4v6a7G6