#3Brain

We're Heading to the French Alps for the 𝟵𝘁𝗵 𝗖𝗲𝗿𝗲𝗯𝗲𝗹𝗹𝘂𝗺 𝗗𝗮𝘆𝘀 to join world-leading researchers at the CNRS Paul Langevin Center in 𝗔𝘂𝘀𝘀𝗼𝗶𝘀 from 𝗠𝗮𝗿𝗰𝗵 𝟮𝟲𝘁𝗵 – 𝟮𝟵𝘁𝗵. If you’re interested in exploring the functional activity of your cerebellar slices, be sure to connect with us.
#3Brain #Cerebellum

Visit 3Brain (Mar 22–25, San Diego) to see how our CorePlate™ HD-MEA platforms turn organoids and spheroids into actionable data. Accelerate your neuro/cardiotoxiology research with functional insights from our BioCAM and HyperCAM Delta.
#2026SOT #ToxExpo #3Brain

New organoid research shows SMA affects far more than motor neurons, revealing widespread CNS disruptions. Using CorePlate™ HD MEAs, researchers found reduced activity, glutamate hyperexcitability, and showed early ASO treatment can rescue function. Huge thanks to the team! #iPSC #HDMEA #3Brain

𝗛𝗼𝘄 𝗱𝗼𝗲𝘀 𝘁𝗵𝗲 𝗯𝗿𝗮𝗶𝗻 𝗯𝗮𝗹𝗮𝗻𝗰𝗲 𝗲𝘅𝗰𝗶𝘁𝗮𝘁𝗶𝗼𝗻 & 𝗶𝗻𝗵𝗶𝗯𝗶𝘁𝗶𝗼𝗻?
A new study by 𝗖𝗿𝗼𝗰𝗰𝗼 et al. (𝗖𝗿𝗲𝗺𝗶𝘀𝗶 𝗟𝗮𝗯) uses stem cell-derived DT/VT populations on CorePlate™ to map how E/I ratios shape network dynamics. Vital research for understanding neurodevelopmental disorders.
#3Brain #HDMEA #electrophysiology

How do we better model cholinergic pathways? By building human brain assembloids. Using CorePlate™ 3D electrodes, the 𝗟𝗶𝘂 𝗟𝗮𝗯 recorded high-res data from hnbM-cortical projections, even transplanting them into mice to establish human-derived pathways. #3Brain #iPSC #HDMEA #Organoids #Assembloids

How DNMT3A mutations reshape neural circuits. New work shows TBRS-associated DNMT3A mutations disrupt human cortical interneuron development, driving GABAergic hyperactivity and abnormal network bursting, revealed using CorePlate™ enabled HD-MEAs.

#Neuroscience #3Brain #Electrophysiology #HDMEA