#CertaintyofEvidence

Gordon H. Guyatt

@guyattgh.bsky.social

1 month ago

GRADE approach to rate the certainty from a network meta-analysis: addressing incoherence - PubMed This article presents official guidance from the Grading of Recommendations Assessments, Development, and Evaluation (GRADE) working group on how to address incoherence when assessing the certainty in the evidence from network meta-analysis. Incoherence represents important differences between direc …

#Incoherence in a network #MetaAnalysis occurs when direct and indirect estimates of the effect of an intervention differ substantially: what to do, and how to use #GRADE to rate the #CertaintyofEvidence? This paper answers the questions.

pubmed.ncbi.nlm.nih.gov/30529648/

Gordon H. Guyatt

@guyattgh.bsky.social

1 month ago

GRADE Guidelines 30: the GRADE approach to assessing the certainty of modeled evidence-An overview in the context of health decision-making - PubMed This conceptual GRADE approach provides a framework for using evidence from models in health decision-making and the assessment of certainty of evidence from a model or models. The GRADE Working Group and the modeling community are currently developing the detailed methods and related guidance for a …

Addressing the #CertaintyofEvidence for #ModellingStudies is a tough nut to crack. Here, a #GRADE overview of the issues in a health context.

pubmed.ncbi.nlm.nih.gov/32980429/

Gordon H. Guyatt

@guyattgh.bsky.social

5 months ago

GRADE guidelines: 21 part 1. Study design, risk of bias, and indirectness in rating the certainty across a body of evidence for test accuracy - PubMed Rating the certainty of a body of evidence using GRADE in Cochrane and other reviews and World Health Organization and other guidelines dealing with in TA studies helped refining our approach. The resulting guidance will help applying GRADE successfully for questions and recommendations focusing on …

If you are using #GRADE to rate #CertaintyofEvidence for diagnostic tests this article that deals with study design, #RiskofBias, and #indirectness provides crucial guidance.

pubmed.ncbi.nlm.nih.gov/32060007/

Gordon H. Guyatt

@guyattgh.bsky.social

6 months ago

GRADE Guidelines 28: Use of GRADE for the assessment of evidence about prognostic factors: rating certainty in identification of groups of patients with different absolute risks - PubMed The same principles GRADE proposed for bodies of evidence addressing treatment and overall prognosis work well in assessing individual prognostic factors, both in noncontextualized and contextualized ...

#GRADE’s primary focus in #SystematicReviews has been on rating certainty in evidence on interventions. But in this article GRADE also provides guidance for #CertaintyofEvidence in #prognosis in which #ObservationalStudies start as high certainty evidence.

pubmed.ncbi.nlm.nih.gov/31982539/

Gordon H. Guyatt

@guyattgh.bsky.social

6 months ago

GRADE guidelines: 21 part 2. Test accuracy: inconsistency, imprecision, publication bias, and other domains for rating the certainty of evidence and presenting it in evidence profiles and summary of f... Using GRADE in Cochrane and other reviews as well as World Health Organization and other guidelines helped refining the GRADE approach for rating the certainty of a body of evidence from TA studies. A...

#GRADE provides guidance for rating #CertaintyofEvidence regarding accuracy of diagnostic tests. This informative paper provides details on assessing #inconsistency, #imprecision, #PublicationBias and other domains and for creating #SummaryofFindings tables.

pubmed.ncbi.nlm.nih.gov/32058069/

Gordon H. Guyatt

@guyattgh.bsky.social

10 months ago

Core GRADE 4: rating certainty of evidence—risk of bias, publication bias, and reasons for rating up certainty This fourth article in a seven part series presents the Core GRADE (Grading of Recommendations Assessment, Development and Evaluation) approach to addressing risk of bias, publication bias, and rating...

A series of 7 papers, Core #GRADE, the essentials of GRADE providing all you need to rate #CertaintyofEvidence and move from evidence to recommendations, is currently appearing in the #BMJ. Today, dealing with #RiskofBias, publication bias, and large effects.

www.bmj.com/content/389/...