#EngramCells

Top: Putative engram cells were identified as GFP (cFos) signals in the indicated mushroom body cell body region dorsal to the calyx 24 hours after spaced training of UAS-mCD8-GFP; kayak-Gal4/Tubp-Gal80ts flies. pERK signals observed after odor exposure 24 hours after training were used to identify cells activated during memory recall tests. Bottom: Schematic for optogenetic reactivation of engram cells. Channelrhodopsin-YFP (ChR2-YFP) was expressed in putative engram cells using the same strategy of expressing GFP above. Twenty-four hours after spaced training, flies were tested for their preference of blue light (which activates channelrhodopsin) vs. green light.

Long-term memories become imprecise as animals age, but what are the neural mechanisms? This study shows that increased #dopamine signaling during #memory consolidation causes memory #EngramCells to respond to inappropriate cues, inducing memory generalization @plosbiology.org 🧪 plos.io/4v62VtD

Top: Putative engram cells were identified as GFP (cFos) signals in the indicated mushroom body cell body region dorsal to the calyx 24 hours after spaced training of UAS-mCD8-GFP; kayak-Gal4/Tubp-Gal80ts flies. pERK signals observed after odor exposure 24 hours after training were used to identify cells activated during memory recall tests. Bottom: Schematic for optogenetic reactivation of engram cells. Channelrhodopsin-YFP (ChR2-YFP) was expressed in putative engram cells using the same strategy of expressing GFP above. Twenty-four hours after spaced training, flies were tested for their preference of blue light (which activates channelrhodopsin) vs. green light.

Long-term memories become imprecise as animals age, but what are the neural mechanisms? This study shows that increased #dopamine signaling during #memory consolidation causes memory #EngramCells to respond to inappropriate cues, inducing memory generalization @plosbiology.org 🧪 plos.io/4v62VtD

Top: Putative engram cells were identified as GFP (cFos) signals in the indicated mushroom body cell body region dorsal to the calyx 24 hours after spaced training of UAS-mCD8-GFP; kayak-Gal4/Tubp-Gal80ts flies. pERK signals observed after odor exposure 24 hours after training were used to identify cells activated during memory recall tests. Bottom: Schematic for optogenetic reactivation of engram cells. Channelrhodopsin-YFP (ChR2-YFP) was expressed in putative engram cells using the same strategy of expressing GFP above. Twenty-four hours after spaced training, flies were tested for their preference of blue light (which activates channelrhodopsin) vs. green light.

Long-term memories become imprecise as animals age, but what are the neural mechanisms? This study shows that increased #dopamine signaling during #memory consolidation causes memory #EngramCells to respond to inappropriate cues, inducing memory generalization @plosbiology.org 🧪 plos.io/4v62VtD

Earth's first bacteria used oxygen about one billion years earlier than we thought Bacteria used oxygen far earlier than expected, reshaping views on early life, evolution, and photosynthesis origins.

Earth’s first bacteria used oxygen about one billion years earlier than we thought: Bacteria used oxygen far earlier than expected, reshaping views on early life, evolution, and photosynthesis origins.

#MemoryEngram #Neuroscience #BrainCells #MemoryFormation #EngramCells #EarthDotCom #EarthSnap

How does the human brain create and retrieve memories? Scientists figured it out memory formation hinges on connections between groups of engram cells, which are neurons thought to capture and store distinct experiences.

How does the human brain create and retrieve memories? Scientists figured it out: Memory formation hinges on connections between groups of engram cells, which are neurons thought to capture and store distinct experiences.

#MemoryEngram #Neuroscience #BrainCells #Memory #EngramCells #EarthDotCom