Latest posts tagged with #HSP90 on Bluesky
New paper out in Protein Science!
We show that ligand binding in the substrate protein actively rewires Hsp90–cochaperone–client dynamics, steering protein fate rather than just stabilizing structures.
doi.org/10.1002/pro....
#ProteinScience #Proteostasis #Hsp90 #MolBio #CompBio
Plant #heat shock protein #Hsp90 enhances stress resistance through integrating #protein quality control, #chloroplast protection, #hormone signal network, and #immune defense
academic.oup.com/jxb/article-...
#PlantScience @jxbotany.bsky.social @sebiology.bsky.social @seanmichaletz.bsky.social
Development of Compact Sensor for Rapid Detection of Cancer Markers for Home Medical Monitoring #Japan #Tokyo #cancer_detection #Home_Healthcare #HSP90
がん早期発見を実現する小型センサの登場！在宅医療への道を切り開く #都産技研 #HSP90 #がんマーカー
東京都立産業技術研究センターが開発した小型センサは、がんを早期に発見し治療をモニタリングする可能性を秘めています。注目です。
がんマーカーを迅速に検出する小型センサの開発とその応用 #東京都 #東京都立産業技術研究センター #がんマーカー #HSP90
東京都立産業技術研究センターが、小型で簡便ながんマーカーの検出センサを開発しました。これにより在宅医療での早期発見が期待されます。
Product Citation 💡 A study conducted by Memorial Sloan Kettering Cancer Center used StressMarq's #HSP90 Antibody to present a method for disease-contextual mapping of protein-protein interaction (PPI) networks.
Paper 💐 http://bit.ly/434sZt3
Product 🌺 http://bit.ly/4oIQrnU
🚀From Bench to Paper | Research in Signal Transduction and Targeted Therapy highlights a promising #Nano-PROTAC for castration-resistant prostate cancer (#CRPC). This PSMA-targeted agent degrades #AR, its chaperone #HSP90, and resistant #AR-V7 (a splice variant).
A new way to beat CRPC resistance.
Researchers developed PSMA-targeted self-assembling Nano-PROTACs that simultaneously degrade AR, AR-V7, and #HSP90 in castration-resistant #ProstateCancer, achieving up to 78% #TumorInhibition and extended survival. #medsky
#OpenAccess in #STTT: doi.org/10.1038/s413...
🚨Publication alert! The final version of our cover feature article is OUT NOW in @cp-trendsbiochem.bsky.social
Read how we connect the #epichaperome with the #chaperone code.
#PTMs #HSP90 #PPI #neuroscience #NetworkBiology
Check out the review article here: www.sciencedirect.com/science/arti...
📸Check out a few photos from @gabrielachiosis.bsky.social and Tanaya's talks at #CSSI2025 @stresscell.bsky.social l last weekend.
#epichaperome #cellularstress #HSP90 #Alzheimers
With growing interest in Hsp90 CTD inhibitors here's a reminder of our CTD study on yeast Hsp90. We showed the NTD and MD to modulate CTD dimerization and shape allostery; super relevant for CTD-targeted drug design #Hsp90 #allostery #DugDesign #Biophysics
www.cell.com/biophysj/ful...
Elysian Pickups HSP90 pickup with black limba top, black hex poles, and a secret inside (its hum canceling)
Elysian Pickups HSP90 pickup with black limba top, black hex poles, and a secret inside (its hum canceling)
Hum canceling HSP90 bobbin, wound with copper wire.
This HSP90 has a secret, can you spot it?
Been working on this one in the background for a while, still have some different things to try, but it's very close to launching.
#ElysianPickups #TunedAperture #metalguitar #metal #guitarpickups #guitarist #guitar #p90 #hsp90 #tone #guitarsky
🌟Very excited to share that our article 'PTMs as Molecular Encoders: Reprogramming Chaperones into Epichaperomes for Network Control in Disease' is out online now in @cp-trendsbiochem.bsky.social
#PTMs #HSP90 #epichaperome #PPI #neuroscience @mskcancercenter.bsky.social
doi.org/10.1016/j.ti...
#3: #PhD Position on Structure–Dynamics–Function Relationship of the #Chaperone #Hsp90:
➤ NMR spectroscopy for atomic-resolution
➤ Single-molecule FRET for time-resolved dynamics
Collab.: @hillerlab.bsky.social & Schmid lab @unibas.ch
More info & online application system: tinyurl.com/mr2em3nk
Deeply saddened by the passing of Dr. Len Neckers-mentor, friend, and a giant in the field of molecular chaperones. I owe much of my career to him. His legacy will live on. My thoughts are with his family. #hsp90
In #cancer, Casein Kinase 2 (CK2) interacts with #HSP90 and puts phosphate groups on Serine 255 and Serine 226 positions of the charged linker region of HSP90 thereby changing its structure or conformation. This dangerous alter ego of HSP90 helps the cancer cells to survive. (7)
#phosphorylation
#Cancer is a multifactorial disease that manifests as a result of chronic cellular stress, a trigger that turns #HSP90 into Mr. Hyde.
Mr. Hyde can now associate with other chaperone protein members and form a gang (high molecular weight assembly) called “epichaperome”. (5)
#epichaperome
In our latest work, now published in
@natcomms.nature.com, we uncover how #HSP90 switches from “good” to “bad” in #cancer. (4)
Heat Shock Protein 90 (HSP90) is a cellular chaperone protein ubiquitously present in human body and is responsible for folding other important proteins in the cell. However, it can exist either as Dr. Jekyll or Mr. Hyde depending on how stressed the cells are. (3) #cellstress #HSP90
Any protein consists of strings of amino acids that fold into distinct different shapes and structures inside the cell depending on the cellular environment. (2)
#proteinstructure #HSP90 #chaperone #cancer #chembio
🧵Follow this thread by Dr. Tanaya Roychowdhury to learn about the intriguing case of #HSP90 - adapted from our recent publication in @natcomms.nature.com (1/8)
#cancer #phosphorylation #epichaperome #conformation #cellstress
www.nature.com/articles/s41...
New life chapter beginning! After some great years at the Sattler lab, I am returning to France with a permanent CNRS position at the CBS, in beautiful Montpellier!
I will continue my work on #HSP90 using #NMR and integrative approaches applied to a new and exciting project!
Curcumin compound reactivates Epstein–Barr virus, offering safer cancer therapy 🔬✨🌿 www.news-medical.net/news/2024110... #Curcumin #Cancer #EpsteinBarrVirus #HSP90 #LyticCycle #ViralTherapy #Oncology #Virus
