#OrganChip

Emily R. Trunnell, Ph.D.

@ertrunnell.bsky.social

1 week ago

Human coronary artery organ‐chip with circulating immune cells recapitulates anti‐inflammatory effect of pulsatile wall strain A fully characterised organ-on-a-chip model of the human coronary artery with endothelial and smooth muscle cells, plus circulating immune cells, created on the Emulate platform. The model successful...

Using @emulatebio.bsky.social’s organ-on-chip platform, researchers at @qmulsems.bsky.social created a human coronary artery organ-chip model of vascular inflammation.

onlinelibrary.wiley.com/doi/10.1002/...

#CardioSky #OrganChip #OrganOnChip #Bioengineering 🧪

Emily R. Trunnell, Ph.D.

@ertrunnell.bsky.social

2 months ago

Also out in @labonachip.rsc.org!

“Breakthrough Technologies and Applications in Organ-On-a-Chip," features some of the most innovative and groundbreaking #OrganChip technology and its applications.

Check out the full collection here: pubs.rsc.org/en/journals/...

#MPS #OrganonaChip #OrganonChip

EARA

@eara.eu

3 months ago

Organ-on-a-chip tests elderly people immune reaction to cancer vaccines Research from the US shows that a new lymph-node-on-a-chip can replicate age-dependent immune responses to cancer vaccines, providing a more accurate testing platform.

Research from the Terasaki Institute shows that a new lymph-node-on-a-chip can replicate age-dependent #immune responses to #cancer vaccines, providing a more accurate #testing platform. www.eara.eu/post/organ-o... #ageing #therapy #vaccine #research #scicomm #USA #researchnews #organchip #NAM

Nikon Microscope Solutions

@healthcare.nikon.com

8 months ago

📄 In a recent #Microscopy #AppNote, we validate the AIM Biotech idenTx series of #OrganOnChip plates for a 3D #Angiogenesis assay of drug efficacy.

🔬 High-resolution 3D imaging was performed using the Nikon AX #Confocal #Microscope system.

🔗 Learn more: bit.ly/4o1Cr9j

#Imaging #MPS #OrganChip

Emily R. Trunnell, Ph.D.

@ertrunnell.bsky.social

10 months ago

Human Organ-On-A-Chip: Technologies Offer Benefits Over Animal Testing but Challenges Limit Wider Adoption We examined "human organ-on-a-chip" technologies—laboratory tools that use human cells to mimic organs, model diseases, and more. This new technology...

In May, GAO published a report on the state of #OrganChip technology, its benefits over experiments on animals, and the steps needed to advance the field. 🧪

Expand this 🧵 for a brief summary + more thoughts 👇 www.gao.gov/products/gao...

#organonachip #microfluidics

Nikon Microscope Solutions

@healthcare.nikon.com

10 months ago

🔬 In this #Microscopy #AppNote we evaluate our AX / AX R #Confocal #Microscope system for imaging a kidney proximal tubule #OrganChip model, demonstrating the sensitivity needed to clearly resolve primary cilia in 3D.

🔗 Click here to view the app note: bit.ly/45pJT74

Emily R. Trunnell, Ph.D.

@ertrunnell.bsky.social

10 months ago

Frontiers | Modeling reproductive and pregnancy-associated tissues using organ-on-chip platforms: challenges, limitations, and the high throughput data frontier Over the past decade, organ-on-chip technology (microphysiological systems or tissue chips) has reshaped in-vitro physiological and pathological modeling and...

In this review, Nina Truong & colleagues from @utmbhealth.bsky.social highlight #organchip systems for reproductive & pregnancy-associated biology. The authors emphasize that maximizing throughput will help them realize their full translational potential.

www.frontiersin.org/journals/bio...

Emily R. Trunnell, Ph.D.

@ertrunnell.bsky.social

10 months ago

Scientific Director, Linda G. Griffith, PhD • The MIT Center for Gynepathology Research

Dr. Linda Griffith and her team at @mit.edu are leading the way in humanizing drug development for #endometriosis and #adenomyosis, integrating #organchip technology with systems biology & systems immunology.

Explore her work:
cgr.mit.edu/people/linda...

Jens Puschhof

@jenspuschhof.bsky.social

1 year ago

Our new #organoid #organchip #coculture review. Congrats @kamilmoskal.bsky.social, Yeseul Lee, Luisa Siegert, Nimisha Khurana from @emil-dkfz.bsky.social @dkfz.bsky.social!
Cool experience connecting the dots between in organotypic models and microbiome with @hansclevers.bsky.social and Eran Elinav

Abish Stephen

@astephen.bsky.social

1 year ago

Only a few days remaining to apply for a #PhD with me at the #EPSRC funded QMUL #CDT. The project involves working on the host-microbe interactions in the human mouth using novel #3D #organotypics / #organchip models #metabolomics

Deadline is Monday, January 6th, 9am.

Emily R. Trunnell, Ph.D.

@ertrunnell.bsky.social

1 year ago

Engineers apply new tech to model deadly brain tumors Researchers are using 3D bioprinting to create artificial blood vessels that can be used to test new custom-tailored drugs and study why brain tumors are so resilient.

A team at #UofCincy & #UNCChapelHill is speeding up the fabrication of human #microphysiologicalsystems using #3Dbioprinting! Read more about how this system could lead to breakthroughs for understanding & treating #glioblastoma.
www.uc.edu/news/article...
#mps #organchip

Emily R. Trunnell, Ph.D.

@ertrunnell.bsky.social

1 year ago

Recent Developments in Glioblastoma‐On‐A‐Chip for Advanced Drug Screening Applications Glioblastoma, an aggressive brain cancer, possesses treatment challenges due to its complexity and the blood-brain barrier. Organ-on-a-chip models are emerging as valuable tools for investigating GBM....

Check out this review on organ-on-a-chip models for #glioblastoma research, drug development, & personalized medicine. By Surjendy Maity, & collaborators at @terasakiinstitute.bsky.social, @dukemedschool.bsky.social, et al.
onlinelibrary.wiley.com/doi/10.1002/...
#organchip #drugdevelopment