Latest posts tagged with #PBPK on Bluesky
VesselAlert
Name: PROGRESS
MMSI: 246303000
Callsign: PBPK
Type: Cargo
Flag: Netherlands
Seen: 27-Mar-2026 08:27:41 CET
Status: under way using engine
Speed: 8.6 kts
Heading: 84 deg
Dest.: PLGDN
Distance: 91.3 nm
Signal RSSI: 0.0 dBFS
Ship AIS VesselAlert © kx1t - link
VesselAlert
Name: PROGRESS
MMSI: 246303000
Callsign: PBPK
Type: Cargo
Flag: Netherlands
Seen: 24-Feb-2026 23:24:22 CET
Speed: 8.2 kts
Heading: 227 deg
Dest.: FRMRS
Distance: 70.6 nm
Signal RSSI: 0.0 dBFS
Ship AIS VesselAlert © kx1t - link
VesselAlert
Name: PROGRESS
MMSI: 246303000
Callsign: PBPK
Type: Cargo
Flag: Netherlands
Seen: 21-Feb-2026 23:38:15 CET
Status: under way using engine
Speed: 9.6 kts
Heading: 67 deg
Dest.: DESTA
Distance: 81.5 nm
Signal RSSI: 0.0 dBFS
Ship AIS VesselAlert © kx1t - link
PBPK mengubah cara emiten menyusun dan melaporkan laporan keuangan mulai 2027, terhubung langsung dengan data pajak.
#coretax #laporan #keuangan #pbpk #perpajakan #regulasi
VesselAlert
Name: PROGRESS
MMSI: 246303000
Callsign: PBPK
Type: Cargo
Flag: Netherlands
Seen: 25-Oct-2025 23:24:50 CEST
Status: under way using engine
Speed: 4.6 kts
Heading: 261 deg
Dest.: FRURO
Distance: 32.5 nm
Signal RSSI: -31.1 dBFS
Ship AIS VesselAlert © kx1t - link
VesselAlert
Name: PROGRESS
MMSI: 246303000
Callsign: PBPK
Type: Cargo
Flag: Netherlands
Seen: 23-Oct-2025 11:26:06 CEST
Status: under way using engine
Speed: 11.6 kts
Heading: 67 deg
Dest.: DEHAM
Distance: 32.4 nm
Signal RSSI: -33.5 dBFS
Ship AIS VesselAlert © kx1t - link
🧠 Predicting how well #drug molecules cross the blood-brain barrier: Gülave et al. built a #MachineLearning model for the unbound brain-to-plasma partition coefficient (98 compounds).
link.springer.com/article/10.1...
👉Best algorithm: Random Forest
💡Great for #CNS drug discovery!
#BBB #PBPK #ML
💊 Morphine is a P-glycoprotein substrate, but do P-gp inhibitors meaningfully change #CNS exposure?
🧠 Likely not: A physiology-based pharmacokinetic #PBPK model predicts negligible impact across populations.
#BBB #DrugInteractions #morphine #modelling #brain
🔗 link.springer.com/article/10.1...
VesselAlert
Name: PROGRESS
MMSI: 246303000
Callsign: PBPK
Type: Cargo
Flag: Netherlands
Seen: 29-Sep-2025 06:30:11 CEST
Status: under way using engine
Speed: 9.1 kts
Heading: 81 deg
Dest.: FIKOK
Distance: 38.4 nm
Signal RSSI: -17.3 dBFS
Ship AIS VesselAlert © kx1t - link
PBPK-iPINNs: Physics-Informed Neural Networks for Brain Modeling
Researchers introduced PBPK‑iPINN, combining physics‑informed neural networks with PBPK models to infer drug parameters from concentration points, achieving accuracy comparable to solvers. Read more: getnews.me/pbpk-ipinns-physics-info... #pbpk #pinns
VesselAlert Vaixell
Nom del Vaixell: PROGRESS
MMSI: 246303000
Indicatiu: PBPK
Tipus: Càrrega
Bandera: Netherlands
Vist a: 20-Jun-2025 22:49:10 CEST
Estat: en marxa usant motor
Velocitat: 9.3 kts
Direcció: 258 deg
Destinació: ESCEU
Distància: 211.8 nm
Senyal RSSI: -21.8 dBFS
Vaixell AIS VesselAle
VesselAlert Vaixell
Nom del Vaixell: PROGRESS
MMSI: 246303000
Indicatiu: PBPK
Tipus: Càrrega
Bandera: Netherlands
Vist a: 28-May-2025 23:55:57 CEST
Estat: en marxa usant motor
Velocitat: 9.6 kts
Direcció: 79 deg
Destinació: ITBLT
Distància: 227.2 nm
Senyal RSSI: -22.2 dBFS
Vaixell AIS VesselAler
VesselAlert Vaixell
Nom del Vaixell: PROGRESS
MMSI: 246303000
Indicatiu: PBPK
Tipus: Càrrega
Bandera: Netherlands
Vist a: 28-May-2025 22:06:02 CEST
Estat: en marxa usant motor
Velocitat: 9.1 kts
Direcció: 83 deg
Destinació: ITBLT
Distància: 227.9 nm
Senyal RSSI: -23.8 dBFS
Vaixell AIS VesselAler
Recent investments in my own personal knowledgebase:
• Consumed a textbook on Bayesian Statistics (metaphorically, of course)
• Currently half-way through a PBPK textbook (diffEq's in bodies, who'd've thunk??)
#pbpk #Bayesianstatistics
Publication alert 🚨: pubmed.ncbi.nlm.nih.gov/39884812/
#QconCAT-based targeted #proteomics to quantify the abundance of 6 transporters and 1 plasma protein marker in 5 placenta samples and associated cell lines and use of the data in a #PBPK model for IVIVE-based prediction of fetal drug exposure.
Andrew Butler from @MHRAgovuk showcases the example of #PBPK to support safest primaquine use in lactation.
Full paper here - a multidisciplinary multinational collaborative partnership
pubmed.ncbi.nlm.nih.gov/39334094/
“For me success is not about the wins and losses. It’s about helping these young fellas be the best versions of themselves on and off the field.” Ted S01E03
Congratulations AliFeleParanj on your successful MSc defense! #pbpk #pbrpk #theranosticdigitaltwins
