#PolycyclicCompounds

Divergent synthesis of two polycyclic frameworks containing tricyclic bridgehead carbon centers by gold-catalyzed cycloisomerization of o-cyclopropylidenemethyl-o′-alkynylbiaryls Compounds containing tricyclic bridgehead carbon centers are privileged structures in drug discovery. In this work, two different polycyclic scaffolds containing this substructure have been accessed b...

Divergent synthesis of two polycyclic frameworks containing tricyclic bridgehead carbon centers

by Manuel A. Fernández-Rodríguez & Patricia García-García et al.

🔗 doi.org/10.1039/D5QO...

#OrganicSynthesis #GoldCatalysis #PolycyclicCompounds #DrugDiscovery #MechanisticChemistry