#Siglecs

GlycoNet researchers are advancing #research tools to study #Siglecs. #glycotime #glycoscience

Fusobacterium nucleatum Lipopolysaccharides O-Antigen Defines a Novel Siglec-7 Binding Epitope Fusobacterium nucleatum (Fn) is a Gram-negative bacterium predominantly found in the human oral cavity, occasionally linked to systemic diseases, including colorectal cancer. Bacterial lipopolysacchar...

F. nucleatum #LPS O-antigen engages #Siglec-7 through a previously unknown epitope, revealing how it may dampen immune responses in #CRC @robertamarchetti.bsky.social @molinarotony.bsky.social 👏 #glycotime #nmr #HostPathogen #Microbiome #Siglecs #microbiology #Glycans pubs.acs.org/doi/10.1021/...

🧪🎊 An incredibly exciting work from the Macauley’s Lab! @siglecdude.bsky.social

📚📌Highly recommended to read and share this quite useful, exciting paper!
#Siglecs #glycotime #glycoimmunology #chemicalbiology

I am so proud of you @zeinab-jc.bsky.social !!🥳

📢 Don’t forget to register!

Join Dr. @siglecdude.bsky.social and Dr. Edward Schmidt (University of Alberta) for a deep dive into new tools for studying Siglecs and their glycan ligands.

🗓 July 28 | 🕛 12 PM MST
🔗 canadianglycomics.ca/training/web...

#glycomics #Siglecs #glycans #glycoscience

Tumors evade immune responses by coating themselves in a dense layer of sugars called sialic acids. These sugars broadcast a signal of "self" to the immune system, recruiting inhibitory #Siglecs, and sweet-talking their way out of immune detection