Latest posts tagged with #TIGIT on Bluesky
dianova Anti-TIGIT (Hu) Clone TG1 is the first monoclonal antibody detecting #TIGIT in routine #FFPE tissue specimen by #IHC.
Validated for the identification of TIGIT positive #Tcells infiltrating human #tumours under pathological conditions.
www.stratech.co.uk/p...
Interesting hypothesis about anti-TIGIT failure
“Selecting an unmutated IgG1 targeting TIGIT, LAG-3, TIM-3, or PD-1 may deplete effector T cells through CDC, ADCC, and/or ADCP, thereby counteracting anticancer efficacy”
#lcsm #tigit
🔬Dianova Anti-TIGIT (Hu) Clone TG1 is the first monoclonal #antibody detecting #TIGIT in routine #FFPE tissue specimen by #IHC
Validated for the identification of TIGIT positive #Tcells infiltrating human #tumours under pathological conditions
🔗www.stratech.co.uk/p...
dianova Anti-TIGIT (Hu) Clone TG1 is the first monoclonal antibody detecting #TIGIT in routine #FFPE tissue specimen by #IHC. Validated for the identification of TIGIT positive #Tcells infiltrating human #tumours under pathological conditions.
www.stratech.co.uk/products/DIA...
#diagnostics
Inhibitory receptor TIGIT
mabnusbiotech.substack.com/p/inhibitory...
#TIGIT #Lifescience #Biology #Mabnus
BIOZOL GmbH Dianova Clone TG1 is the first monoclonal #antibody for #IHC detection of #cancer #immunology checkpoint biomarker #TIGIT (Tcell immunoreceptor with Ig & ITIM domains) in standard #FFPE human tissue specimen
https://www.stratech.co.uk/products/DIA-TG1-M-DIA/
#diagnostics #histopathology
BIOZOL GmbH Dianova Clone TG1 is the first monoclonal #antibody for #IHC detection of #cancer #immunology checkpoint biomarker #TIGIT (Tcell immunoreceptor with Ig & ITIM domains) in standard #FFPE human tissue specimen
www.stratech.co.uk/p...
#diagnostics #histopathology
#dianova Anti-TIGIT (Hu) Clone TG1 is the first monoclonal antibody detecting #TIGIT in routine #FFPE tissue specimen by #IHC Validated for the identification of TIGIT positive #Tcells infiltrating human #tumours under pathological conditions
More here: stratech.co.uk/produ...
.#dianova Anti-TIGIT (Hu) Clone TG1 is the first monoclonal antibody detecting #TIGIT in routine #FFPE tissue specimen by #IHC
Validated for the identification of TIGIT positive #Tcells infiltrating human #tumours under pathological conditions
More here: www.stratech.co.uk/products/DIA...
www.tandfonline.com/doi/full/10....
Emerging roles of checkpoint molecules on B cells
#Bcells #TIM-1 #TIGIT #PD-1
Exploring TIGIT Dimers: A New Frontier in Cancer Immunotherapy
What’s unique about #TIGIT? Unlike other immune checkpoints, TIGIT modulates both T and NK cells, presenting new opportunities to tackle resistant #cancers, especially when paired with PD-1 inhibitors. bit.ly/40zDp2P
Development of two next gen IO molecules has been discontinued. Vibostolimab (anti #TIGIT) and favezelimab (anti LAG3) programs both being shuttered. Development in this space has been significantly hampered by the lack of predictive biomarkers.
www.merck.com/news/merck-p...
2) 💥Wow! Prof. Elizabeth M Burton #immunotherapy expert @mdanderson.bsky.social shows that high #B7H3 ( #PDL3 / #CD276 ) correlates with non-responders to neoadjuvant IO/ High #TIGIT & Low #B7H3 was assoc with responders/marker of T cell activation? #Bridge2024 @sitcancer.bosky.social
Still amazes me how positivity for #TIGIT ligands expression is not added as inclusion criteria in these trials, as done for PD-L1. Any rationale for not including it?
#biosky #oncology
SKYSCRAPER-01 has failed in overall survival
Long awaited results from Genentech/Roche on SKYSCRAPER-01, a Phase 3 evaluating the anti #TIGIT tiragolumab in combo with Tecentriq vs Tecentriq alone for patients w PD-L1-high, locally advanced or metastatic NSCLC
www.businesswire.com/news/home/20...
It's true that the #TIGIT space has seen ups and downs in the last few years. Curious to see clinical trials implementing better patient stratification strategies based on epithelial/mesenchymal markers to improve responses to #immunotherapy!
Interesting summary of #morpheusliver #HCC data and issues. #tigit inh. #tiragolumab + #tecentriq #avastin performed well vs. #IMBRAVE150 doublet but latter underperformed. PFS unprecedented. Exciting but await #IMBRAVE152 to confirm #livertwitter...
