#TrendsMicrobiol

Ákos T Kovács

@evolvedbiofilm.bsky.social

1 year ago

Moonlighting antibiotics: the extra job of modulating biofilm formation The widespread use of antibiotics to treat bacterial infections has led to the common perception that their only function is to inhibit growth or kill bacteria. However, it has become clear that when ...

Moonlighting antibiotics: the extra job of modulating biofilm formation

#TrendsMicrobiol from Diego Serra

[including summary of B. subtilis biofilm papers from Kolter/Losick/Shank labs 2001-2015 + few newer papers on TasA from Romero lab & on NDmed from Briandet lab]

www.cell.com/trends/micro...

Ákos T Kovács

@evolvedbiofilm.bsky.social

1 year ago

Deciphering bacterial protein functions with innovative computational methods Bacteria colonize every niche on Earth and play key roles in many environmental and host-associated processes. The sequencing revolution revealed the remarkable bacterial genetic and proteomic diversity and the genomic content of cultured and uncultured bacteria. However, deciphering functions of novel proteins remains a high barrier, often preventing the deep understanding of microbial life and its interaction with the surrounding environment. In recent years, exciting new bioinformatic tools, many of which are based on machine learning, facilitate the challenging task of gene and protein function discovery in the era of big genomics data, leading to the generation of testable hypotheses for bacterial protein functions. The new tools allow prediction of protein structures and interactions and allow sensitive and efficient sequence- and structure-based searching and clustering. Here, we summarize some of these recent tools which revolutionize modern microbiology research, along with examples for their usage, emphasizing the user-friendly, web-based ones. Adoption of these capabilities by experimentalists and computational biologists could save resources and accelerate microbiology research.

Deciphering bacterial protein functions with innovative computational methods

#TrendsMicrobiol from @asaflevylab.bsky.social

www.cell.com/trends/micro...

Ákos T Kovács

@evolvedbiofilm.bsky.social

1 year ago

Agents of change: a partnership between mobile genetic elements facilitates rapid bacterial adaptation While the evolutionary interests of mobile genetic elements may differ from those of their bacterial hosts, these elements can be beneficial for their hosts by delivering, disrupting, or activating ge...

Agents of change: a partnership between mobile genetic elements facilitates rapid bacterial adaptation

#TrendsMicrobiol Spotlight by Elizabeth Duan, @oliviakosterlitz.bsky.social and Benjamin Kerr

on the Nat Eco Evo paper from @sanmillan.bsky.social group

www.cell.com/trends/micro...

Ákos T Kovács

@evolvedbiofilm.bsky.social

1 year ago

From advisors to mentors: fostering supportive mentorship in academia A supportive mentorship has long-lasting effects on shaping students' personal and professional development. Here, we outline important aspects of mentoring and indicators of good mentors, focusing on...

From advisors to mentors: fostering supportive mentorship in academia

#TrendsMicrobiol

www.cell.com/trends/micro...

Ákos T Kovács

@evolvedbiofilm.bsky.social

1 year ago

The role of noncoding RNAs in bacterial immunity The evolutionary arms race between bacteria and phages has driven the development of diverse anti-phage defense mechanisms. Recent studies have identified noncoding RNAs (ncRNAs) as key players in bac...

The role of noncoding RNAs in bacterial immunity

#TrendsMicrobiol David Mayo-Muñoz, Huijuan Li, Mario Rodríguez Mestre, Rafael Pinilla-Redondo from #microUCPH

www.cell.com/trends/micro...

Ákos T Kovács

@evolvedbiofilm.bsky.social

1 year ago

Balancing act: counteracting adverse drug effects on the microbiome

#TrendsMicrobiol from Lisa Maier lab Tübingen

www.sciencedirect.com/science/arti...

Ákos T Kovács

@evolvedbiofilm.bsky.social

1 year ago

The double play of a phage HTH regulator Bacteriophages use anti-CRISPR (Acr) proteins to inhibit CRISPR-Cas systems. The expression of Acr is regulated by anti-CRISPR-associated (Aca) proteins, which are helix-turn-helix (HTH) repressors th...

The double play of a phage HTH regulator

#TrendsMicrobiol Spotlight from Sylvain Moineau

www.cell.com/trends/micro...

Ákos T Kovács

@evolvedbiofilm.bsky.social

1 year ago

Microbial bases of herbivory in beetles The ecological radiation of herbivorous beetles is among the most successful in the animal kingdom. It coincided with the rise and diversification of flowering plants, requiring beetles to adapt to a ...

Microbial bases of herbivory in beetles

#TrendsMicrobiol by Marleny Garcia Lozano and @hassansalem.bsky.social

www.cell.com/trends/micro...

Ákos T Kovács

@evolvedbiofilm.bsky.social

1 year ago

Phages to the rescue: in situ editing of the gut microbiota The gut microbiome contains numerous bacteria tied to our health. However, genetically modifying this community remains a major challenge. Brödel et al. take a critical step by engineering bacteriopha...

Phages to the rescue: in situ editing of the gut microbiota

#TrendsMicrobiol Spotlight by Charlotte Kamm and Chase L Beisel

www.cell.com/trends/micro...

Ákos T Kovács

@evolvedbiofilm.bsky.social

1 year ago

Bacillus velezensis stimulates resident rhizosphere Pseudomonas stutzeri for plant health through metabolic interactions AbstractTrophic interactions play a central role in driving microbial community assembly and function. In gut or soil ecosystems, successful inoculants are

In our previous #TrendsMicrobiol review (doi.org/10.1016/j.ti...), we described that most literature reports competition or nautral interaction between Bacillus and Pseudomonas
(note, we also published on cooperative biofilms, see here doi.org/10.1038/s413...)
[2/n]

Ákos T Kovács

@evolvedbiofilm.bsky.social

1 year ago

A mechanistic framework for complex microbe-host symbioses

#TrendsMicrobiol from Miguel Lurgi at #SwanseaUni

www.cell.com/trends/micro...

Ákos T Kovács

@evolvedbiofilm.bsky.social

1 year ago

The role of cyclic nucleotides in bacterial antimicrobial resistance and tolerance Nucleotide signalling molecules – mainly cyclic 3′,5′-adenosine phosphate (cAMP), bis-(3′,5′)-cyclic diguanosine monophosphate (c-di-GMP), and bis-(3′,5′)-cyclic diadenosine monophosphate (c-di-AMP) –...

The role of cyclic nucleotides in bacterial antimicrobial resistance and tolerance

#TrendsMicrobiol

www.cell.com/trends/micro...

Ákos T Kovács

@evolvedbiofilm.bsky.social

1 year ago

Bacillus lipopeptides as key players in rhizosphere chemical ecology

#TrendsMicrobiol by Guillaume Balleux & Monica Höfte et al from Marc Ongena

www.cell.com/trends/micro...

Ákos T Kovács

@evolvedbiofilm.bsky.social

1 year ago

The HIPS 2024 symposium: highlighting advances in pharmaceutical sciences in infection research

The HIPS 2024 symposium: highlighting advances in pharmaceutical sciences in infection research
-in #TrendsMicrobiol
www.sciencedirect.com/science/arti...

Ákos T Kovács

@evolvedbiofilm.bsky.social

1 year ago

The growing repertoire of phage anti-defence systems

#TrendsMicrobiol

www.sciencedirect.com/science/arti...

Ákos T Kovács

@evolvedbiofilm.bsky.social

1 year ago

Inside the microbial black box: a redox-centric framework for deciphering microbial metabolism Microbial metabolism influences the global climate and human health and is governed by the balance between NADH and NAD+ through redox reactions. Hist…

Inside the microbial black box: a redox-centric framework for deciphering microbial metabolism

#TrendsMicrobiol Opinion

www.sciencedirect.com/science/arti...

christoph_STCmicrobeblog

@christophstc.bsky.social

1 year ago

tagging #MicroSky for #TrendsMicrobiol on gene transfer agents GTA)

STC had it too, recently > schaechter.asmblog.org/schaechter/2...

Ákos T Kovács

@evolvedbiofilm.bsky.social

1 year ago

Gene transfer agents: structural and functional properties of domesticated viruses

#TrendsMicrobiol from Paul CM Fogg

www.sciencedirect.com/science/arti...

Ákos T Kovács

@evolvedbiofilm.bsky.social

1 year ago

Linking microbiome temporal dynamics to host ecology in the wild

#TrendsMicrobiol Opinion by Kirsty Marsh, @stubearhop.bsky.social and Xavier Harrison

www.sciencedirect.com/science/arti...

Ákos T Kovács

@evolvedbiofilm.bsky.social

1 year ago

Microbial nitrogen transformation processes across environments: more than just a cycle Nitrogen (N) is unique amongst the bioessential elements in that its major reservoir is in the atmosphere, as triple-bonded N2, which comprises 78% of the atmosphere. Breaking the extremely strong tri...

Microbial nitrogen transformation processes across environments: more than just a cycle

#TrendsMicrobiol Editorial by Jennifer Glass and Kathrin Rousk

www.cell.com/trends/micro...

Ákos T Kovács

@evolvedbiofilm.bsky.social

1 year ago

Small peptides: novel targets for modulating plant–rhizosphere microbe interactions

-in #TrendsMicrobiol

www.sciencedirect.com/science/arti...

Ákos T Kovács

@evolvedbiofilm.bsky.social

1 year ago

T6SS-effector hunters uncover PIX: a novel delivery/marker domain Gram-negative bacteria use the T6SS to eject effectors into prey cells, aided by delivery domains. Recently uncovered by Carobbi et al., a new deliver…

T6SS-effector hunters uncover PIX: a novel delivery/marker domain

#TrendsMicrobiol Spotlight by @pbernalt6ss.bsky.social on the #CellReports paper by Andrea Carobbi et al from @drdorsalomon.bsky.social (and Guido Sessa)

www.sciencedirect.com/science/arti...

Ákos T Kovács

@evolvedbiofilm.bsky.social

1 year ago

Extracellular vesicles: new bullets in the fungal armory

#TrendsMicrobiol Forum

www.sciencedirect.com/science/arti...

Ákos T Kovács

@evolvedbiofilm.bsky.social

1 year ago

Critically evaluating the relative importance of phage in shaping microbial community composition

#TrendsMicrobiol Opinion by Meaghan Castledine and Angus Buckling

www.cell.com/trends/micro...

Gina Lewin

@ginalewin.bsky.social

1 year ago

Images of Rothia colonies and cells

The new Microbe of the Month is Rothia!

www.sciencedirect.com/science/arti...

Happy to contribute to this article with @asuddaby.bsky.social, Shannon West, and @cbibberson.bsky.social

#TrendsMicrobiol

Ákos T Kovács

@evolvedbiofilm.bsky.social

2 years ago

Effectors and environment modulating rice blast disease: from understanding to effective control
-in #TrendsMicrobiol
www.sciencedirect.com/science/arti...

Ákos T Kovács

@evolvedbiofilm.bsky.social

2 years ago

Strategies for developing phages into novel antimicrobial tailocins

#TrendsMicrobiol by Cedric Woudstra et al from Lone Brøndsted

www.sciencedirect.com/science/arti...

Ákos T Kovács

@evolvedbiofilm.bsky.social

2 years ago

Sinorhizobium (Ensifer) meliloti, #TrendsMicrobiol Microbe of the Month from Turlough Finan at #McMasterU

www.sciencedirect.com/science/arti...

Ákos T Kovács

@evolvedbiofilm.bsky.social

2 years ago

Bradyrhizobium japonicum (diazoefficiens)- Microbe of the Month at #TrendsMicrobiol by Alasteir Ong and Mark O'Brian

www.sciencedirect.com/science/arti...

Ákos T Kovács

@evolvedbiofilm.bsky.social

2 years ago

Cryptococcus neoformans: plant–microbe interactions and ecology

#TrendsMicrobiol from Katja Salomon Johansen #uni_copenhagen

www.sciencedirect.com/science/arti...