#USP8

Risk of recurrence after successful surgery for Cushing's disease and association with USP8 genotype and tumour size: an international, retrospective, longitudinal cohort study Combined USP8 genotype–tumour size identified patients at increased risk of recurrence, particularly in largely heterogeneous groups of patients with non-invasive tumours or low postoperative serum co...

Combined #USP8 #genotype–tumour size identified patients at increased risk of #recurrence, particularly in largely heterogeneous groups of patients with non-invasive tumours or low postoperative serum cortisol not considered high risk in standard care www.thelancet.com/journals/lan...
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Risk of recurrence after successful surgery for Cushing's disease and association with USP8 genotype and tumour size: an international, retrospective, longitudinal cohort study Combined USP8 genotype–tumour size identified patients at increased risk of recurrence, particularly in largely heterogeneous groups of patients with non-invasive tumours or low postoperative serum co...

Our results support a novel three-tier risk assessment system that integrates #USP8 #genetic status and tumour size to predict #recurrence after first #pituitary #surgery www.thelancet.com/journals/lan...
#Cushing's disease
#OpenAccess

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USP8 genotype and tumour size as predictors for recurrence in Cushing's disease The study by Qilin Zhang and colleagues published in The Lancet Diabetes & Endocrinology evaluates the risk of recurrence following successful surgery for Cushing's disease and examines its associatio...

Maya Beth Lodish comments on:
#USP8 #genotype and tumour size as predictors for #recurrence in #Cushing's disease thelancet.com/journals/lan...
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New—Risk of #recurrence after successful #surgery for #Cushing's disease and association with #USP8 #genotype and tumour size: an international, retrospective, longitudinal cohort study thelancet.com/journals/lan...
#OpenAccess

#MedSky #EndoSky

Prevalence and clinical associations of USP8 variants in corticotroph tumours: a systematic review and aggregate data meta-analysis of 2171 cases AbstractObjective. Somatic USP8 variants are common in corticotroph tumours, but their reported prevalence and association with clinical characteristics va

Prevalence and clinical associations of #USP8 variants in corticotroph tumours: a systematic review and aggregate data meta-analysis of 2171 cases by Luis G Perez-Rivas et al

EJE Volume 192, Issue 6, June 2025
Open access 👉 doi.org/10.1093/ejen...

#Cushingsdisease

Elucidation of short linear motif-based interactions of the MIT and rhodanese domains of the ubiquitin-specific protease 8 - Biology Direct Ubiquitin-specific protease 8 (USP8) is a deubiquitinating enzyme with essential functions in protein trafficking and stability. It is a multidomain protein, with an N-terminal MIT (microtubule intera...

We uncover that the #USP8 rhodanese domain is a #peptide binding module that binds short linear motifs in potential substrates: biologydirect.biomedcentral.com/articles/10....