#MedSky

Shicheng Guo

@shihcheng.bsky.social

3 minutes ago

Protein and genomic models achieve 99% precision, 92% recall in predicting antiphage systems, revealing 12 new ones in Escherichia & Streptomyces. PMID:41926572, Science 2026, @ScienceMagazine https://doi.org/10.1126/science.adv8275 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Barts Cancer Institute (Queen Mary University of London)

@qmbci.bsky.social

10 minutes ago

New £1m clinical trial launches to improve quality of life for people with blood cancer Researchers have been awarded £1m to launch a new clinical trial for people with myelodysplastic syndromes, a form of blood cancer with limited treatment options.

Congratulations to Dr @kevinrouault.bsky.social, who has been awarded £1m from @cancerresearchuk.org to launch a clinical trial aiming to improve quality of life for people with myelodysplastic syndromes, a form of blood cancer with limited treatment options.

🧪 #medsky #oncosky @qmul.bsky.social

YSUBassoon

@bassoonysu.bsky.social

1 hour ago

#MedSky

Peter MacPherson

@petermacp.bsky.social

1 hour ago

We found that #TB epidemics are becoming increasingly urbanised.

Important implications for supporting effective public health interventions to end tuberculosis epidemics.

🧪 #MedSky
@uofgshw.bsky.social
@kchorton.bsky.social
@nswartwood.bsky.social

journals.plos.org/plosmedicine...

PLOS Medicine

@plosmedicine.org

1 hour ago

Urban and rural prevalence of tuberculosis in low- and middle-income countries: A systematic review and meta-analysis In a systematic review and meta-analysis, Seyed Alireza Mortazavi and colleagues investigate urban versus rural differences in adult pulmonary tuberculosis prevalence between 2000 and 2024 in 26 low- ...

In this systematic review & meta-analysis, Mortazavi & colleagues (@petermacp.bsky.social) investigate urban vs rural differences in #TB prevalence between 2000 and 2024 in 26 low- and middle-income countries, finding that TB epidemics have become increasingly urbanized 🧪 #MedSky
plos.io/3O79BqY

Rhea Liang

@liangrhea.bsky.social

1 hour ago

Who gets to choose? Inequality and the illusion of choice in medical careers Click on the article title to read more.

Eliot Rees and Guilherme Movio don't miss in this blistering commentary on structural inequity in medicine.

'Career choice is not simply about what students want; it is about what they can access, sustain and afford.'

#MedSky #MedEd

Springer Medizin

@springermedizin.de

2 hours ago

Auf Riechstörung folgt oft der körperliche Abbau Wer im Alter Gerüche schlecht identifiziert, läuft Gefahr, dass seine körperlichen Kräfte besonders rasch sinken: Gehgeschwindigkeit, Balance und Griffstärke nehmen im Laufe von sechs bis sieben Jahren deutlich stärker ab als bei gutem Riechvermögen.

Wer im Alter Gerüche schlecht identifiziert, läuft Gefahr, dass seine körperlichen Kräfte besonders rasch sinken: Gehgeschwindigkeit, Balance und Griffstärke nehmen im Laufe von sechs bis sieben Jahren deutlich stärker ab als bei gutem Riechvermögen. (kostenfrei nach Reg.) #medsky #hno #Medizin

@vikkypaedia10.bsky.social

2 hours ago

Are we witnessing the "End of Cognitive Authority in Medicine" ... #meded #medsky #bioethics
Read and opine: open.substack.com/pub/vikkypae...

Transfusion Evidence Library

@transfusionlib.bsky.social

2 hours ago

Randomized, sham-controlled trial of intraoperative ticagrelor removal to reduce perioperative bleeding OBJECTIVE: Patients on ticagrelor who are undergoing cardiac surgery before completing guideline-recommended washout are at high risk for severe bleeding. This study evaluated whether a novel drug removal device reduces bleeding in patients operated within 2 days from ticagrelor discontinuation. METHODS: Eligible patients were randomized 1:1 to intraoperative DrugSorb-ATR or sham control. Primary safety end point was adverse events at 30 days. Efficacy was assessed by composite end points comprising bleeding events using Universal Definition of Perioperative Bleeding (UDPB) and 24-hour chest tube drainage (CTD) in the overall and isolated coronary artery bypass grafting (CABG) populations with a hierarchical win ratio (WR) method. RESULTS: In total, 140 patients were randomized; 132 had surgery and received a study device; and 92% were isolated CABG. Mean age was 65 ± 5 years, and 15% were female. The primary safety end point was met, with similar adverse events reported between groups. The primary efficacy end point was not met in the overall or CABG populations (Win ratio [WR], 1.07; 95% CI, 0.72-1.58; P = .748 and WR, 1.33; 95% CI, 0.86-2.04; P = .202 respectively). The supplementary efficacy end point was met in the CABG population (WR, 1.59; 95% CI, 1.02-2.46, P = .041) with significant reductions also shown in large CTD bleeding events (P = .016) and major bleeding, a composite of severe bleeding events or 24-hour CTD ≥1 L (P = .041). The number needed to treat to prevent a major bleed was 6. CONCLUSIONS: Intraoperative use of DrugSorb-ATR is safe in patients operated within 2 days of ticagrelor discontinuation. Although the primary end point was not met in the overall population, there were significant reductions in severe bleeding events in the prespecified CABG population.

🔗 #TransfusionEvidence Library link to:
Randomized, sham-controlled trial of intraoperative ticagrelor removal to reduce perioperative bleeding
by Mack et al.
www.transfusionevidencelibrary.com/alerts/artic...
#MedSky

Transfusion Evidence Library

@transfusionlib.bsky.social

2 hours ago

Image showing a PICO summary for: Randomized, sham-controlled trial of intraoperative ticagrelor removal to reduce perioperative bleeding by Mack et al. featured in the Transfusion Evidence Alert - March 2026

From the #Transfusion Evidence Alert:

Randomized, sham-controlled trial of intraoperative ticagrelor removal to reduce perioperative bleeding
by Mack et al.
🔗 Link in the comments
#MedSky

Transfusion Evidence Library

@transfusionlib.bsky.social

3 hours ago

Comparative efficacy of prehospital resuscitation strategies on mortality for patients with major trauma: a network meta-analysis BACKGROUND AND IMPORTANCE: Patients with major trauma face high rates of coagulopathy, hemorrhage, and organ failure, with prehospital resuscitation strategies critical for stabilization. Comparative evidence on prehospital blood [red blood cells (RBCs) and plasma] and non-blood [intravenous crystalloids and dextran, intravenous crystalloids only, and tranexamic acid (TXA)] resuscitation strategies remains limited and inconclusive. OBJECTIVES: To evaluate and compare the efficacy of prehospital blood and non-blood resuscitation strategies in patients with major trauma using network meta-analysis. DESIGN, SETTINGS, AND PARTICIPANTS: Network meta-analysis of randomized controlled trials (RCTs). Databases: PubMed, CINAHL, Cochrane Library, and Web of Science and reference lists of relevant previous studies. Participants: patients with major trauma. INTERVENTION OR EXPOSURE: Prehospital blood (RBC + plasma, RBC, and plasma) and non-blood (intravenous crystalloids + dextran, intravenous crystalloids only, and TXA) resuscitation strategies. OUTCOME MEASURE AND ANALYSIS: Study outcomes were 24-h and 28-day mortality. Data analysis was performed using Frequentist and Bayesian frameworks on MetaInsight, an R-Language web-based analytical platform, presenting odds ratio (OR) and corresponding 95% confidence interval (95% CI). Ranking of prehospital resuscitation strategies was confirmed by the surface under cumulative ranking. MAIN RESULTS: A total of 15 RCTs involving 7504 participants were included. Compared with intravenous crystalloids only, RBC + plasma (OR: 0.68, 95% CI: 0.38-1.22), plasma (OR: 0.72, 95% CI: 0.46-1.16), TXA (OR: 0.73, 95% CI: 0.52-1.04), RBC (OR: 0.81, 95% CI: 0.22-3.08), and intravenous crystalloids + dextran (OR: 0.91, 95% CI: 0.65-1.28) demonstrated no significant difference in reducing 24-h mortality. Similarly, TXA (OR: 0.83, 95% CI: 0.35-1.92), intravenous crystalloids + dextran (OR: 0.84, 95% CI: 0.46-1.52), RBC + plasma (OR: 0.88, 95% CI: 0.21-3.73), RBC (OR: 0.94, 95% CI: 0.10-8.64), and plasma (OR: 0.97, 95% CI: 0.38-2.46) revealed no significant difference in reducing 28-day mortality compared with intravenous crystalloids only. Based on ranking probabilities, RBC + plasma (65.8%) for 24-h mortality and TXA (74.6%) for 28-day mortality were ranked highest. CONCLUSION: Prehospital blood (RBC + plasma, RBC, and plasma) and non-blood (intravenous crystalloids + dextran and TXA) resuscitation strategies were associated with comparable nonsignificant effects on early and late mortality. Current evidence is insufficient to support the superiority of a single prehospital intervention with future large-scale RCTs needed to clarify role of prehospital blood and non-blood resuscitation strategies.

#TransfusionEvidence Library link to:
Comparative efficacy of prehospital resuscitation strategies on mortality for patients with major trauma: a network #meta-analysis
by Hsu et al.
www.transfusionevidencelibrary.com/alerts/artic...
#MedSky

Transfusion Evidence Library

@transfusionlib.bsky.social

3 hours ago

Image showing a PICO summary for: Comparative efficacy of prehospital resuscitation strategies on mortality for patients with major trauma: a network meta-analysis by Hsu et al. featured in the Transfusion Evidence Alert - March 2026

From the #Transfusion Evidence Alert:

Comparative efficacy of prehospital resuscitation strategies on mortality for patients with major trauma: a network #meta-analysis
by Hsu et al.
🔗 Link in the comments
#MedSky

Austin J. (A.J.)

@therealajay.bsky.social

3 hours ago

#medsky #signalboost

Gregory MS

@gregory-ms.com

3 hours ago

Stem cell transplantation holds significant promise for regenerative medicine, but immune rejection remains a major obstacle. Recent advances leverage CRISPR/Cas9 to engineer hypoimmunogenic induced pluripotent stem cells. Future re...
#MSchat #MS #Neurology #MultipleSclerosis #NeuroSky #MedSky

Haemnet

@haemnet.bsky.social

3 hours ago

New on #Haemcast: members of #LFWBD discuss talking to their children about their #bleedingdisorder — and how their concerns aren't always what you might expect.

On podcast platforms, YouTube & here:
https://loom.ly/uvvmvQk

#haemophilia #families #children #podcast
#HemeSky #MedSky

Shicheng Guo

@shihcheng.bsky.social

4 hours ago

A woman in her 30s developed melanoma linked to a BAP1-inactivated melanocytic tumor. What's next in understanding genetic risks? PMID:41848722, JAMA Dermatol 2026 https://doi.org/10.1001/jamadermatol.2025.5354 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

@themedicalrepublic.bsky.social

4 hours ago

Medicare mental health telehealth changes worsen access and ‘miss their target’ - Medical Republic Bring the exemptions back, witnesses tell senate inquiry.

Medicare mental health telehealth changes worsen access and ‘miss their target’, by Mariella Attard. Bring the exemptions back, witnesses tell senate inquiry. www.medicalrepublic.com.au/medicare-men... #medsky

@themedicalrepublic.bsky.social

4 hours ago

DoHDA encouraged to pursue more ‘coherent’ cardiac imaging rules - Medical Republic Shall we give GPs education about when to claim an item? Nah, just make the claiming process needlessly complex instead.

DoHDA encouraged to pursue more ‘coherent’ cardiac imaging rules, by Holly Payne. Shall we give GPs education about when to claim an item? Nah, just make the claiming process needlessly complex instead. www.medicalrepublic.com.au/dohda-encour... #medsky

Shicheng Guo

@shihcheng.bsky.social

5 hours ago

Dissecting yeast RNA polymerase I: Integrating biochemistry, biophysics & dynamics to unveil transcription initiation's quantitative landscape. PMID:41732916, Nucleic Acids Res 2026, @NAR_Open https://doi.org/10.1093/nar/gkag153 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Carolyn Barber, MD

@cbarbermd.bsky.social

5 hours ago

#BlueSky #MedSky #LawSky #PoliSky

Donna M

@donnamenner.bsky.social

5 hours ago

2/2. The probiotics that do make it through the stomach stay with us only temporarily, but do not colonize. So how did we get some colonized in the beginning of life?
#Medsky
#Gastrosky
#Nutrition
#Microbiome
#Aging
#Longevity
#BrainGutAxis

Current Medical Science

@currentmedscience.bsky.social

6 hours ago

Causal Link between Gut Microbiota and Infertility: A Two-sample Bidirectional Mendelian Randomization Study

This MR analysis reveals a bidirectional causal link between #GutMicrobiota & #Infertility, offering new perspectives on #Microbial mechanisms underlying #ReproductiveHealth & informing future #diagnostic & #therapeuticstrategies. #medsky

To read: doi.org/10.1007/s115...

Hannah Harris Green

@whatsitlike.me

8 hours ago

🧪 #drugsky #medsky #opioid #recovery

Shicheng Guo

@shihcheng.bsky.social

9 hours ago

Harnessing glucocorticoid receptor antagonism to enhance the efficacy of cardiac regenerative growth factors and cytokines | Nature Cardiovascular Research Myocardial injuries lead to cardiomyocyte loss and heart failure. Endogenous glucocorticoids, via the glucocorticoid receptor (GR), limit cardiomyocyte regeneration. Here we show that glucocorticoids suppress mammalian (murine) cardiomyocyte proliferative response to regenerative growth factors and cytokines. GR activation in neonatal cardiomyocytes upregulated MAPK–ERK inhibitors ERRFI1 and DUSP1. Using neuregulin 1 as a model, we demonstrated that glucocorticoids inhibit growth-factor-induced ERK activation, nuclear translocation and transcriptional output. Errfi1 and Dusp1 knockdown restored growth-factor-induced proliferation of glucocorticoid-exposed cardiomyocytes. Cardiac expression of DUSP1 and ERRFI1 increased postnatally, coinciding with regenerative capacity decline. In juvenile and adult cardiomyocytes, regenerative growth factors failed to induce the MAPK–ERK pathway and proliferation; however, DUSP1 inhibition restored these responses. GR antagonism enhanced growth-factor

Unlock heart healing! Glucocorticoid receptor (GR) blockage boosts heart cell regeneration via growth factors like Neuregulin1. PMID:41652035, Nat Cardiovasc Res 2026 https://doi.org/10.1038/s44161-026-00776-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Thanh Neville, MD, MSHS

@thanhneville.medsky.social

9 hours ago

I got a request from someone I did not know to write a letter of recommendation for promotion for another person I did not know. I was really surprised, but apparently this is not unheard of in academia? #academicmedicine #medsky

NEJM AI

@ai.nejm.org

9 hours ago

Figure 1. Health Care Needs and Resources by Rural–Urban Classification Using the 2013 National Center for Health Statistics Urban–Rural Classification Scheme for Counties.

A new Perspective examines the misalignment between health needs, health care resources, and #AI implementation capacity, demonstrating that Hart’s inverse care law persists in the AI era. Read the full Perspective: nejm.ai/4v0RvHx

#MedSky #MLSky

@NurseTexas1

@nursetexas1.bsky.social

9 hours ago

I can’t wait. If you haven’t read her first book, “In Shock” get it now. #MedSky #NurseSky

@bpattonpac.bsky.social

9 hours ago

Doctor in South Texas Community Detained by Border Patrol

Anyone have too many doctors where they live? Because we sure as shit don't. Waitlists for years. There is nothing about this administration that makes anyone healthier.
#medsky
www.nytimes.com/2026/04/07/u...

Nephrology Journal Club

@nephjc.bsky.social

10 hours ago

a man with a beard and a white shirt says time for the grand reveal ALT: a man with a beard and a white shirt says time for the grand reveal

In jut 1 hour #NephJC is unveiling something new...
#NephSky #MedSky

BaladoCritique : club de lecture médical

@baladocritique.bsky.social

10 hours ago

Tenecteplase for Acute Non–Large Vessel Occlusion 4.5 to 24 Hours After Ischemic Stroke Onset This trial tests whether intravenous tenecteplase thrombolysis initiated between 4.5 and 24 hours after symptom onset benefits patients with acute ischemic stroke due to non–large vessel occlusion wit...

“Tenecteplase for Acute Non–Large Vessel Occlusion 4.5 to 24 Hours After Ischemic Stroke Onset.”
Publié ce jour dans @jama.com.
#MedSky #NeuroSky
jamanetwork.com/journals/jam...