Latest posts tagged with #cutaneous on Bluesky
"Skin-related manifestations are common & may be the 1st signs of #APS. 40% of APS pts who hv #cutaneous manifestations go on to develop multisystemic #thrombotic events which underscores the need to be extra vigilant" buff.ly/XofExpO
@achronicvoice.com
#AntiphospholipidSyndrome
Is it a pedestrian death to freeze to death on sidewalk if no collision was involved ?
Hot take: #Cutaneous dermal injuries (sun damage, melanomas, etc) are the most common pededstrian injury.
Another reason I enjoy night cycling. Why look sun-ravished when you can settle for wind-beaten ?
Assessment of seasonal variation in #cutaneous #microvasculature function in healthy adults shows lower #nitricoxide mediated cutaneous #vasodilation in winter/early-spring compared to summer/early-fall.
doi.org/10.14814/phy...
#Endothelium
"Skin-related manifestations are common & may be the 1st signs of #APS. 40% of APS pts who hv #cutaneous manifestations go on to develop multisystemic #thrombotic events which underscores the need to be extra vigilant" buff.ly/XofExpO
@achronicvoice.com
#AntiphospholipidSyndrome
The Beacon trial is notable for a few reasons. First, it’s the first industry-sponsored, placebo-controlled study to deliver a clearly positive readout in CS. Second, the magnitude and speed of response stood out. At 16 weeks, patients receiving brepocitinib 45 mg saw a 22.3-point mean improvement on the CSAMI-A score versus just 0.7 points on placebo, with statistically significant separation as early as Week 4. Every patient in the 45-mg arm achieved a clinically meaningful ≥10-point improvement. For context, CSAMI-A ranges from 0 to 165 and captures both disease activity and lesion severity. On the Investigator’s Global Assessment, 69% of patients on 45 mg improved by at least two points to a score of clear or almost clear—another strong signal in a disease where disfiguring skin lesions can drive real psychosocial burden. Even the lower 15-mg dose showed meaningful improvement, while placebo patients saw minimal benefit, reinforcing a clear drug effect and dose response. Analysts have called the data “exceptional,” and clinicians involved described it as a “watershed moment” for a historically neglected disease. Proivant plans to move into Phase 3 after FDA discussions later this year. With prior Phase 3 success in dermatomyositis and ongoing development in noninfectious uveitis, brepocitinib is quietly shaping up to be a very important asset in immune-mediated inflammatory disease. Curious to see how regulators view the Phase 2 package—and whether CS could become another meaningful label expansion down the line.
Proivant Therapeutics just reported very strong Phase 2 data for brepocitinib in cutaneous sarcoidosis (CS)—a condition with no FDA-approved treatments and limited off-label options today.
#BCIC #cutaneous #sarcoidosis
"Skin-related manifestations are common & may be the 1st signs of #APS. 40% of APS pts who hv #cutaneous manifestations go on to develop multisystemic #thrombotic events which underscores the need to be extra vigilant" buff.ly/XofExpO
@AChronicVoice
#AntiphospholipidSyndrome
"Skin-related manifestations are common & may be the 1st signs of #APS. 40% of APS pts who hv #cutaneous manifestations go on to develop multisystemic #thrombotic events which underscores the need to be extra vigilant" buff.ly/XofExpO
@achronicvoice.com
#AntiphospholipidSyndrome
Typical of CREEPING ERUPTION, OR #CUTANEOUS #LARVA MIGRANS.
The patient was treated with albendazole. After 2 weeks, the lesion healed completely. No recurrence was seen at a 2-month follow-up visit.
2/2
"Skin-related manifestations are common & may be the 1st signs of #APS. 40% of APS pts who hv #cutaneous manifestations go on to develop multisystemic #thrombotic events which underscores the need to be extra vigilant"
🔗
buff.ly/XofExpO
@achronicvoice.com
#AntiphospholipidSyndrome
"Skin-related manifestations are common & may be the 1st signs of #APS. 40% of APS pts who hv #cutaneous manifestations go on to develop multisystemic #thrombotic events which underscores the need to be extra vigilant" buff.ly/XofExpO
@achronicvoice.com
#AntiphospholipidSyndrome
"#Skin-related manifestations are common & may actually be the 1st signs of #AntiphospholipidSyndrome. 40% of APS patients who have #cutaneous manifestations go on to develop multisystemic #thrombotic events, which underscores the need to be extra vigilant": buff.ly/XofExpO
Via @achronicvoice.com
"#Skin-related manifestations are common & may actually be the 1st signs of #AntiphospholipidSyndrome..40% of APS patients who hv #cutaneous manifestations go on to develop multisystemic #thrombotic events, which underscores the need to be extra vigilant"
🔗
buff.ly/XofExpO
"#Skin-related manifestations are common & may actually be the 1st signs of #AntiphospholipidSyndrome..40% of APS patients who hv #cutaneous manifestations go on to develop multisystemic #thrombotic events, which underscores the need to be extra vigilant"
🔗
buff.ly/XofExpO
@achronicvoice.com
New collab out with Jennifer Zhang & Amy Petty of @dukemedschool.bsky.social #Dermatology Department! #scRNAseq performed by #DukeMGC
'Insights into #Keratinocyte and Immunologic Landscape in #Cutaneous #Graft-Versus-Host Disease through #SingleCellTranscriptomics' 🧬💻
doi.org/10.1016/j.xj...
Amy Petty, postdoc of Jennifer Zhang's lab, 2025 publication inspired the talk - 'Insights into complex #keratinocyte landscape in acute and chronic #cutaneous #GVHD through single cell RNA sequencing’: sciencedirect.com/science/arti...
In clinical practice, there is mounting concern about the burden of severe #cutaneous adverse reactions (SCAR). This #CIOMS consensus report provides insights and latest thinking on this important topic in #medicine and #pharmacovigilance
cioms.ch/publications...
Antiphospholipid Syndrome (It's Not 'just' A Blood Clotting Disorder) - Learn More On: achronicvoice.com . (A plastic figurine of a human torso with organs exposed is in the background.)
" #Skin -related manifestations are common & may actually be the 1st signs of #AntiphospholipidSyndrome ..40% of APS patients who hv #cutaneous manifestations go on to develop multisystemic #thrombotic events, which underscores the need to be extra vigilant": buff.ly/2G7uuiB
#ChronicIllness
This month’s cover features a keratinocyte mitochondrion damaged by UVB radiation, which then releases reactive oxygen species (red spheres) and Z-DNA complexed with ZBP1 into the cytoplasm. Image credit: A. Fisher/Science Immunology
The March cover of Science Immunology highlights work from @kahlenberglab.bsky.social on #photosensitivity in #cutaneous #lupus patients and how #UVB induced release of #mitochondrial #Z-DNA in complex with ZBP1 activates #cGAS-STING and fuels type I IFN production.
www.science.org/doi/10.1126/...
Letter to editor
Adagrasib-induced photodistributed hyperpigmentation: Two case reports and pathogenetic hypothesis
#Adagrasib #Skin #Hyperpigmentation #TargetedTherapy #ProteinKinaseInhibitor #Cutaneous #ADRs
www.em-consulte.com/article/1717...
In our January issue: Parasite of the Month: #Leishmania #amazonensis, the #etiological #agent of #cutaneous #leishmaniasis #CL & #anergic #diffuse CL #ADCL, authored by M.S.A. Garcia, V.A.O. Filho, M.B.C. Brioschi, K. Minori & D.C. Miguel @unicampoficial.bsky.social
www.cell.com/trends/paras...
cutaneous
- Relating to or existing on or affecting the skin
Learn More...
#definition #cutaneous #meaning #english #ielts
Pacientes con sarcoidosis cardíaca tienen sarcoidosis en la cabeza y centro de la cara y nariz, sin diferencias según raza o etnia, por lo que deben ser referidos al cardiólogo #sarcoidosis. #cutaneous #cardiac jamanetwork.com/journals/jam...
Comprehensive look at health effects from #flooding -
#Infections...
#waterborne
#mosquito-borne
#rodent-borne
#cutaneous
#respiratory
#gastrointestinal
Fecal pathogens -> water bodies
Surface runoff -> pathogens -> downstream collection systems
#IDSky
www.nejm.org/doi/full/10....
Pharmacovigilance
Acute generalized exanthematous pustulosis: Analysis of cases managed in a Tunisian tertiary hospital
em-consulte.com/article/1638...
#AcuteGeneralizedExanthematous #Pustulosis #Drug #Bites #Severe #Cutaneous #ADRS
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