#osteogenic

PLOS Biology

@plosbiology.org

1 hour ago

Global deletion of Pcif1 decreases bone mass. Top left: Representative Micro-CT images of femurs from 6-week-old male Pcif1−/− knockout mice and Pcif1+/+ littermates. Scale bar, 200 μm. Bottom left: Representative images of Von Kossa staining of undecalcified femoral sections. Scale bar, 500 μm. Right: Schematic diagram of the manuscript created using selected icons from BioRender.

m6A RNA mods play a role in #bone homeostasis, but what about m6Am? This study shows that the PCIF1 m6Am #methyltransferase supports bone mass maintenance by stabilizing Wnt pathway transcripts & promoting #osteogenic differentiation of mesenchymal stem cells @plosbiology.org 🧪 plos.io/4tC9lPO

Signal Transduction and Targeted Therapy

@sigtrans-sttt.bsky.social

2 days ago

cGMP–PKG signaling attenuates #AorticValveCalcification by activating ULK1-mediated #Autophagy and inhibiting #Osteogenic differentiation, suggesting a promising #TherapeuticTarget against calcific #AorticValveDisease.
#STTT #OpenAccess: doi.org/10.1038/s413...

Signal Transduction and Targeted Therapy

@sigtrans-sttt.bsky.social

2 weeks ago

This #STTT study shows that activation of the cGMP–PKG signaling pathway attenuates #AorticValveCalcification by promoting ULK1-mediated #Autophagy, which suppresses #Osteogenic differentiation in valvular interstitial cells.

#OpenAccess: doi.org/10.1038/s413...

Genes & Diseases Journal

@genesndiseases.bsky.social

3 months ago

TIGAR protects against #GIOP by promoting #osteogenic differentiation and reducing #OxidativeStress through activation of the autophagy–Nrf2–ROS pathway, highlighting TIGAR as a potential therapeutic target for improving #BoneLoss in GIOP.

#OpenAccess: doi.org/10.1016/j.ge...

Genes & Diseases Journal

@genesndiseases.bsky.social

3 months ago

#BMP9 upregulates #SIRT5 to drive #osteogenic differentiation in #MSCs and promote #BoneDefect repair by reducing HIF‑1α acetylation/malonylation—expanding BMP9 mechanisms and identifying targets to boost #osteogenesis for #TissueEngineering.

#OpenAccess: doi.org/10.1016/j.ge...

Signal Transduction and Targeted Therapy

@sigtrans-sttt.bsky.social

3 months ago

DT-109 significantly reduces #atherosclerotic lesions and #VascularCalcification in #primates by downregulating #inflammation and #osteogenic markers, highlighting DT-109 as a promising therapy for #CardiovascularDisease.

#OpenAccess in #STTT: doi.org/10.1038/s413...

Genes & Diseases Journal

@genesndiseases.bsky.social

5 months ago

New research shows miR-378 overexpression accelerates OVX-induced bone loss by modulating #Osteogenic processes through Traf3, positioning anti-miR-378 therapy as a promising #therapeutic strategy for #Osteoporosis. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

Amaia Cipitria

@amaiacipitria.bsky.social

7 months ago

Anisotropic hydrogel degradation enhances 3D collective mesenchymal stromal cell alignment, mechanotransduction and osteogenic differentiation Tissue engineering involves assembling cells and mimicking the complex anisotropic architecture of biological tissues to perform specific functions. T…

After a long journey, finally published in @ActaBio: beautiful work by #ClaudiaGarrido showing how #anisotropic #hydrogel degradation enhances #collective cell behavior, #mechanotransduction and #osteogenic differentiation 👉 bit.ly/3J98HHG. Congratulations! @ChariteBerlin @biogipuzkoa @Ikerbasque

Genes & Diseases Journal

@genesndiseases.bsky.social

9 months ago

TIGAR improves #osteogenic differentiation by inducing #autophagy to degrade Keap-1 and enhance the activation & nuclear translocation of Nrf2, which subsequently reduces intracellular #OxidativeStress and #apoptosis in osteoblasts. #medsky

#OpenAccess:

Andrew Holle

@ahcells.bsky.social

10 months ago

We also found that when MSCs migrate through tight channels, they become more #osteogenic. One thing we love about microchannels: here, the only way those cells could have gotten to the right side is by confined migration, so we know their #confinement history. (5/n)

Natural Health News

@naturalhealthnews.bsky.social

11 months ago

What is osteogenic loading? Here's how to build stronger bones using exercise Bulletproof your muscles, joints and bones.

#Osteogenic loading, also called bone loading, is the process of applying “good” stress to your #bones to keep them strong as you age. You can exercise for bone #health; it’s the key factor in building strong bones and preventing #osteoporosis later in life.
www.tomsguide.com/wellness/fit...

Genes & Diseases Journal

@genesndiseases.bsky.social

1 year ago

Bone morphogenetic protein 9 (BMP9) upregulates the expression of sirtuin 5 (SIRT5), which in turn enhances BMP9-induced #osteogenic differentiation in mouse embryonic fibroblasts (MEFs) by mediating the deacetylation and demalonylation of Hif-1 alpha. #medsky

#OpenAccess: https://buff.ly/435YV0N