Latest posts tagged with #smFRET on Bluesky
👀 Your #molecules are doing something exciting! But what, exactly? Discover - when and why - #smFRET is the method of choice to use alongside your current techniques, adding a layer of dynamic data that can quantify #biomolecularconformations and complex formation. Learn more > buff.ly/arAGYZ4
Beautiful work showing the power of #smFRET for uncovering the complexities ensembles in biology, this time for #RNA structures during transcription- congratulations @olivierduss.bsky.social !!
🙌 Congratulations to Chadda et al. on their new paper! #smFRET on the EI-FLEX provided a highly complementary technique alongside SEC, mass spectrometry, mass photometry & bulk FRET to elucidate the pathway that forms mature intasomes from viral #DNA & retrovirus integrase dimers.👀 > buff.ly/mkBUmjc
Nice overview of another cool #smFRET study, this time unpicking protein folding dynamics @timcraggs.bsky.social @ei-science.bsky.social
It's been a privilege to be involved with this. #FRET approaches have so many potential applications for linking in vitro studies with in cell behaviours, but lacked a consistent benchmarking molecule that works across systems: not any more! #IDRs #smFRET #singlemolecule
Want to add easy access to #smFRET, #FCS and #FCCS to your core facility? Our new tools for single-molecule measurements offer:
💪 Reliable performance
⚡ Intuitive workflows
🦶 Small footprint, big impact
Learn more and get in touch > buff.ly/q8KQw0i
#corefacilities #biophysics #singlemolecule
Congratulations to Alison Twelvetrees, Evelyn Smith and team at the University of Sheffield on their publication in iScience! - www.cell.com/iscience/ful...
Amazing to see the in-cell labelling and smFRET measurements in cell lysate.
#smfret #celllysate #singlemolecule #proteins
Want to add fast, solution-based #single-molecule dynamics to your workflow? Our new, practical handbook shows how confocal #smFRET reveals conformational change, heterogeneity & nanoscale distances, with clear, step-by-step guidance from basics to advanced analysis > buff.ly/xHefIrP
Biology happens when molecules interact - in solution, in motion, in fleeting moments. Freely diffusing smFRET captures these dynamics with nanometre precision. Our new practical #smFRET handbook distils principles & analysis for confident, in-solution data. 📘 buff.ly/AgGQCLY #singlemolecule
Curious how single-molecule tools are transforming our understanding of DNA? Chadda et al. used smFRET and DEER to reveal that RPA partially wraps single-stranded DNA instead of simply stretching it - academic.oup.com/nar/article/...
#DNA #smFRET #molecularbiology #proteinDNAinteractions
smFRET tracks one molecule at a time to reveal real low/high-FRET populations, dynamic transitions, and nanoscale changes that traditional FRET masks. Learn more - bit.ly/44TVTwy #smFRET #biophysics #singlemolecule
It's Christmas in advance in the lab, as we recieved the first ever #Luminosa from @picoquant.bsky.social to be installed in France. It will be available on the PIBBS facility, as a combo with a Brucker Atomic force microscope for #mecanobiology, #smFRET, #FLIM, #FCS, #AFM applications and more.
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👋 Calling all Prague-based structural biologists and single-molecule enthusiasts! You are invited to listen and learn from @timcraggs.bsky.social on 9 Dec at the J. Heyrovský Institute of Physical Chemistry - www.jh-inst.cas.cz/seminar/tim-... #singlemolecule #structuralbiology #smfret #fcs
Curious about new routes for labelling often complicated RNAs for single-molecule FRET studies? You'll want to check out Graham et al.'s recently published work in ChemPhysChem (congratulations 🥳) - buff.ly/SkaruHO
#rna #rnaresearch #virology #singlemolecule #smfret #nucleicacids
🔎 How does in-solution smFRET reveal the dynamic structure–function links in complex proteins?
Watch Prof. @shenk0128.bsky.social's seminar using the EI-FLEX to probe Rag GTPase conformations. Q&A covers labelling, HMMs & why solution-based smFRET matters.
youtu.be/2AfskEVyRCI #smfret #biophysics
Professor Robb says: "Our EI-FLEX platform has been central to understanding the molecular details of viral replication and drug action. It’s quickly become a core instrument across many aspects of our virology research." Read her paper here - doi.org/10.1093/nar/... #smFRET #drugdevelopment
📢 Our Exciting Seminars are back! Join @timcraggs.bsky.social & @shenk0128.bsky.social on Nov 20 for 'Mapping the global conformation of the Rag GTPase heterodimer with single-molecule FRET' > us06web.zoom.us/meeting/regi...
#biophysics #lifescienceevent #molecularmedicine #biochemistry #smfret
Oh this looks 🤩. #smFRET
Thanks for making all these efforts to outreach. In case anyone has questions, please do not hesitate to contact me. 📝🧑💻
The entrance lobby for the new Exciting Instruments facility - with cool 3D logos and reflections in the window an interesting way around!
Love the optics here - see the reflection!
We are welcoming a lot of people to @ei-science.bsky.social getting great data on their own biological systems for prelim data for grants.
It’s nice to have a greta space to welcome them to!
Is there an #smFRET experiment you’d like to try? Ping me here!
Our work on DNA G4 interactions with Zuo1 in collaboration with @paeschkelab.bsky.social and the Penedo lab is out in @narjournal.bsky.social 😍
Full text: academic.oup.com/nar/article/...
#G4 #G-Quadruplex #NMR #smFRET #ChIP-qPCR
Average doesn't really exist... so why measure it?
Our compact and easy-to-use instrument has been designed to help researchers access dynamic single-molecule insights from their own lab benchtops.
Find out more about the EI-FLEX and book a demo bit.ly/3KZK3Ku
#singlemolecule #smfret #fcs
I am very much looking forward to an inspiring week at #Mifobio2025 - thanks for the invite! I am counting on learning new exciting (pun intended) insights on fluorescence and happy to share our experience and vision on large throughput #smFRET .
Can smFRET deliver reproducible, absolute distance measurements?
Yes! Check out Hellenkamp et al.'s (2018) paper to learn more > www.nature.com/articles/s41...
#singlemolecule #smfret #biophyics #biochemistry
🚀 Our 'professor in a box', a quick-watch smFRET explainer video, a very exciting Chair appointment and more... see what we've been up to in September in the latest edition of our newsletter - buff.ly/EDA6U5s
#structuralbiology #moleculardynamics #singlemolecule #smfret #fcs #deeptech #startups
Rush! The application deadline for this #PhD or #Postdoc opportunity in my group is TODAY!
#smFRET #DyeCycling #nano-photonics & Co
🤔 How did Groves et al. use the FLEX to reveal insights about SARS-CoV-2’s RNA polymerase? Find out here > doi.org/10.1093/nar/...
Want to know more about the FLEX? Learn more, request a tech spec or book a demo on our website: excitinginstruments.com/ei-flex/?utm... #smfret #RNA #nucleicacids
👋 At the Midlands Biophysics Network meeting today? So are we!
Visit our stand to chat about how we're bringing solution-based single-molecule techniques right to your benchtop - no extensive training required.
#midlandsbiophysicsnetworkmeeting #biophysics #singlemolecule #smfret #fcs
Thrilled to see long-time #FRET experts moving into single-molecule work with our technology at McMaster University! Plus, our instrument now also supports University at Albany's core facility with #smFRET & #FCS! A very Exciting week! 🙌 #biophysics #singlemolecule #structuralbiology
Missing biomolecular dynamics at picomolar levels? The EI-FLEX makes single-molecule research quick and easy with precision and stability. Watch Dr. Quinn below and book a demo: excitinginstruments.com/contact-us/?...
#singlemolecule #structuralbiology #moleculardynamics #smFRET #FCS
Heading to the Austrian Cryo-EM Symposium in November? Let's catch up! We'll be on hand to share how freely diffusing smFRET can complement this already exquisitely detailed technique #cryoEM #smfret #singlemolecule
