#CLL cells accumulate lipid peroxides & iron, predisposing them to #ferroptosis; #BTK inhibition raises #TFRC and sensitizes cells, while combining #ibrutinib with #GPX4 blockade enhances efficacy, with TFRC and #ACSL1 emerging as targets.
#OpenAccess #STTT: doi.org/10.1038/s413...
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