#Bioanalysis

The Analytical Scientist

@analyticalsci.bsky.social

1 week ago

The rise of GLP-1 therapeutics is pushing peptide bioanalysis to new limits.

Experts Todd Stawicki and Shane Needham (SCIEX), discuss how high-resolution MS is helping labs deliver greater sensitivity, selectivity, and speed.

🔗 https://ow.ly/ELi350Yqcz9

#MassSpectrometry #GLP1 #Bioanalysis

BioMassSpec

@realbiomassspec.bsky.social

1 month ago

A fully automated novel solid-phase extraction method for siRNA drug extraction and quantitation across multiple tissues using LC-MS Approaches such as liquid–liquid extraction and two-step liquid–liquid extraction combined with SPE has been widely used for extraction of oligonucleotide therapeutics. It has been more challenging...

Full article: A fully automated novel solid-phase extraction method for siRNA drug extraction and quantitation across multiple tissues using LC-MS #Bioanalysis www.tandfonline.com/doi/full/10....

BioMassSpec

@realbiomassspec.bsky.social

1 month ago

A simple and highly sensitive LC-MS/MS bioanalytical method for phosphorodiamidate morpholino oligonucleotides in plasma LC-MS/MS is widely used for the quantification of phosphorodiamidate morpholino oligomers, but its low sensitivity is a problem. In addition, solid-phase extraction, a pretreatment method generally...

Full article: A simple and highly sensitive LC-MS/MS bioanalytical method for phosphorodiamidate morpholino oligonucleotides in plasma #Bioanalysis www.tandfonline.com/doi/full/10....

SCIEX

@sciex.bsky.social

1 month ago

The BioA Collective: Your Mass Spec Bioanalysis Community This is a dedicated space for professionals, newcomers, and enthusiasts passionate about bioanalysis using mass spectrometry. Our mission is to foster a collaborative environment where members can share knowledge, discuss challenges, and explore applications of mass spectrometry in bioanalysis.

𝗛𝗮𝘃𝗲 𝘆𝗼𝘂 𝗵𝗲𝗮𝗿𝗱 𝗼𝗳 '𝗧𝗵𝗲 #𝗕𝗶𝗼𝗔𝗖𝗼𝗹𝗹𝗲𝗰𝘁𝗶𝘃𝗲'❓

It's YOUR #MassSpec Bioanalysis Community! It's a dedicated space for professionals, newcomers, and enthusiasts passionate about #bioanalysis using #MassSpectrometry to network, collaborate and connect.

Join on #LinkedIn now 👉

BioMassSpec

@realbiomassspec.bsky.social

1 month ago

A new sensitive derivatization assay of PrC-210 in plasma and tissues using liquid chromatography coupled with tandem mass spectrometry PrC-210 is a direct-acting reactive oxygen species (ROS) scavenger. It is active when administered orally, IV, or subcutaneously. Its profound efficacy in preclinical models makes it a candidate to...

A new sensitive derivatization assay of PrC-210 in plasma and tissues using liquid chromatography coupled with tandem mass spectrometry #Bioanalysis www.tandfonline.com/doi/full/10....

BioMassSpec

@realbiomassspec.bsky.social

1 month ago

A validated UHPLC-MS/MS method for determination of BPI-43487 and its metabolite BPI-43739 in human plasma and its application to a pharmacokinetic study in Chinese patients with advanced solid tumors BPI-43487 is a novel irreversible fibroblast growth factor receptor 4 inhibitor.A simple and reliable liquid chromatography-tandem mass spectrometry method was developed and validated for simultane...

A validated UHPLC-MS/MS method for determination of BPI-43487 and its metabolite BPI-43739 in human plasma and its application to a pharmacokinetic study in Chinese patients with advanced solid tumors #Bioanalysis www.tandfonline.com/doi/full/10....

BioMassSpec

@realbiomassspec.bsky.social

2 months ago

Rapid quantification of bile acids in serum by LC-MS/MS and application to serum bile acid profile in voriconazole administered patients with invasive fungal infections Disruption of bile acid homeostasis is implicated in the pathogenesis and progress of several liver diseases, including drug-induced liver injury (DILI). A rapid liquid chromatography-tandem mass s...

Rapid quantification of bile acids in serum by LC-MS/MS and application to serum bile acid profile in voriconazole administered patients with invasive fungal infections #Bioanalysis www.tandfonline.com/doi/full/10....

Thiard News@F4F

@newsen.bsky.social

2 months ago

Dash Bio Unveils State-of-the-Art Bioanalysis Facility to Revolutionize Drug Development in Waltham, MA Dash Bio has inaugurated a 24,000 sq ft GLP-compliant facility in Waltham, aiming to transform drug analysis turnaround times from months to mere days.

Dash Bio Unveils State-of-the-Art Bioanalysis Facility to Revolutionize Drug Development in Waltham, MA #United_States #Waltham #Dash_Bio #bioanalysis

SCIEX

@sciex.bsky.social

2 months ago

𝗪𝗵𝘆 𝗻𝗼𝘁 𝗷𝗼𝗶𝗻 𝗮 𝗻𝗲𝘄 𝗰𝗼𝗺𝗺𝘂𝗻𝗶𝘁𝘆 𝘁𝗵𝗶𝘀 𝘆𝗲𝗮𝗿❓ Check out the #BioACollective: Your Mass Spec Bioanalysis Community on #LinkedIn 👉 bit.ly/4kML0TU

#BioACommunity #Bioanalysis #MassSpectrometry #Biopharma #Pharma #SCIEX #MeetTheBioACommunity

BioMassSpec

@realbiomassspec.bsky.social

2 months ago

Determination of R/S-enantiomers of methamphetamine and amphetamine in human hair with chiral stationary phase LC-MS/MS As the synthetic abused drug with high addictive potential, methamphetamine (METH) and its major metabolite amphetamine (AMP) are chiral compounds. The S-enantiomer of METH is primarily abused beca...

Determination of R/S-enantiomers of methamphetamine and amphetamine in human hair with chiral stationary phase LC-MS/MS #Bioanalysis www.tandfonline.com/doi/full/10....

SCIEX

@sciex.bsky.social

2 months ago

𝗡𝗲𝘄 𝘆𝗲𝗮𝗿, 𝗻𝗲𝘄 𝗵𝗮𝗯𝗶𝘁𝘀? Join the #BioACollective: Your Mass Spec Bioanalysis Community to share ideas and meet like-minded people.

Join us on #LinkedIn today 👉 bit.ly/4kML0TU

#BioACommunity #Bioanalysis #MassSpectrometry #Biopharma #Pharma #SCIEX #MeetTheBioACommunity

BioMassSpec

@realbiomassspec.bsky.social

2 months ago

A simple, sensitive and rapid bioanalytical method for quantifying cannabidiol (CBD), 7-OH-CBD and 7-COOH-CBD in human plasma Reliable methods for measuring plasma concentrations of cannabidiol (CBD) and its metabolites are essential for pharmacokinetic studies. Several methods have been published, some involve complex pr...

A simple, sensitive and rapid bioanalytical method for quantifying cannabidiol (CBD), 7-OH-CBD and 7-COOH-CBD in human plasma #Bioanalysis #MassSpec www.tandfonline.com/doi/full/10....

BioMassSpec

@realbiomassspec.bsky.social

2 months ago

Development and validation of a bioanalytical method to quantify povorcitinib in human skin with clinical application Quantification of drug concentrations in human skin is essential for understanding mechanisms of action in dermatologic therapeutics but remains analytically challenging. The study aimed to develop...

Full article: Development and validation of a bioanalytical method to quantify povorcitinib in human skin with clinical application #Bioanalysis #MassSpec www.tandfonline.com/doi/full/10....

BioMassSpec

@realbiomassspec.bsky.social

3 months ago

Mass spectrometry approaches for monitoring therapeutic response in major depressive disorder Major depressive disorder (MDD) is a complex and disabling psychiatric condition, often chronic and recurrent, for which treatment selection remains largely guided by trial-and-error. Objective bio...

Mass spectrometry approaches for monitoring therapeutic response in major depressive disorder #Bioanalysis www.tandfonline.com/doi/full/10....

BioMassSpec

@realbiomassspec.bsky.social

3 months ago

Improving sensitivity and selectivity of human ACTH[1–39] quantitation using online size exclusion chromatography and antibody-free LC-HRMS Quantitation of adrenocorticotropic hormone (ACTH) in human plasma by clinical immunoassays is prone to selectivity challenges, whereas quantitation by mass spectrometry assays (MSA) is limited by ...

Improving sensitivity and selectivity of human ACTH[1–39] quantitation using online size exclusion chromatography and antibody-free LC-HRMS #Bioanalysis www.tandfonline.com/doi/full/10....

BioMassSpec

@realbiomassspec.bsky.social

3 months ago

Bioanalytical method development for polmacoxib in rat plasma using LC–MS/MS and Its preclinical pharmacokinetic evaluation To develop and validate a rapid, sensitive, and selective LC – MS/MS method for quantifying polmacoxib (POL) in rat plasma and integrating for preclinical pharmacokinetic evaluation.POL was quantif...

Bioanalytical method development for polmacoxib in rat plasma using LC–MS/MS and Its preclinical pharmacokinetic evaluation #Bioanalysis www.tandfonline.com/doi/full/10....

SCIEX

@sciex.bsky.social

4 months ago

Navigating the bioanalytical complexities of oligonucleotide therapeutics Eshani Galermo explores the technological advances that are shaping the future of oligonucleotide quantitation and characterization.

Oligonucleotide therapeutics = new hope, new challenges.

SCIEX expert Eshani Galermo explains how advanced LC-MS strategies and emerging technologies are shaping bioanalysis.

Read more: www.bioanalysis-zone.com/sciex-itz-na...

#Bioanalysis #Oligonucleotides #DanaherNews

Atanas G. Atanasov

@atanas-g-atanasov.bsky.social

4 months ago

🏆 Separations Young Investigator Award (2000 CHF; Deadline: 31 December 2025), and other Awards

🔗 inpst.net/awards/

🌐 #INPST #Bioanalysis

SCIEX

@sciex.bsky.social

4 months ago

Veloxity Labs Acquires SCIEX Accurate Mass Spectrometer, the ZenoTOF 8600 System, to Accelerate Peptide and Complex Bioanalysis The first bioanalytical CRO in the United States to bring the ZenoTOF 8600 system online; expands capacity and adds selectivity/sensitivity headroom for GLP-1 receptor agonists and broader peptide…

#DidYouHear? US-based CRO Veloxity Labs continues to expand its bioanalytical capabilities with the ZenoTOF 8600 system 👀

This marks a meaningful step forward in complex bioanalysis.

🔗 www.biospace.com/press-releas...

#MassSpec #Bioanalysis #Peptides #Proteomics #SCIEX #ZenoTOF8600

SCIEX

@sciex.bsky.social

4 months ago

SCIEX ZenoTOF 8600 system acquired by Veloxity Labs Veloxity Labs acquires the SCIEX ZenoTOF 8600 system to accelerate peptide and complex bioanalysis.

Veloxity Labs is the first U.S. bioanalytical CRO to adopt the #ZenoTOF8600 system! The platform adds high-resolution selectivity and sensitivity to peptide workflows, supporting GLP-1 receptor agonists and complex matrices.

We're proud to support this expansion in regulated #bioanalysis.
#MassSpec

BioMassSpec

@realbiomassspec.bsky.social

5 months ago

MS-DIAL pre-processing for mining schistosomiasis metabolites in urine samples from the Okavango Delta of Botswana from a GC-MS dataset Metabolites were re-mined using MS-DIAL from an SPME dataset preprocessed using AMDIS/Metab R in which data was acquired by GC-MS from schistosomiasis infected (positive) and non-infected (negative...

MS-DIAL pre-processing for mining schistosomiasis metabolites in urine samples from the Okavango Delta of Botswana from a GC-MS dataset #Bioanalysis www.tandfonline.com/doi/full/10....

Taylor & Francis Research

@tandfresearch.bsky.social

5 months ago

Cover of Bioanalysis featuring hexagonal images: assays, graphs showing 'LacNAc' peaks, a gloved hand with a blood tube, machine parts, a circuit board, & antigen-antibody interaction.

Guest advisor Lauren Stevenson from Immunologix Laboratories.

📣 #CallForPapers at #Bioanalysis with guest advisor Lauren Stevenson from Immunologix Laboratories!

📖 We invite researchers & industry experts to contribute on immunogenicity testing challenges in biological therapeutics. Submit your research & reviews here by Jan 31 2026:
spr.ly/6003Aa2AW

BioMassSpec

@realbiomassspec.bsky.social

5 months ago

Progress in monitoring molecular, cellular and metabolic dynamics using mass spectrometry imaging Mass spectrometry imaging (MSI) enables the visualization of hundreds to thousands of analytes in biological tissues. MSI is also capable of mapping time-dependent processes that, combined with the...

Progress in monitoring molecular, cellular and metabolic dynamics using mass spectrometry imaging #Bioanalysis www.tandfonline.com/doi/full/10....

BioMassSpec

@realbiomassspec.bsky.social

5 months ago

Development and validation of an LC-MS/MS method for the quantification of novel therapeutic TT-478, a selective adenosine receptor 2B antagonist, for a phase I/II clinical trial TT-478 is a novel adenosine receptor 2B antagonist, administered orally as a prodrug (TT-702) for the treatment of advanced metastatic prostate cancer in a Phase I/II clinical trial setting. A liqu...

Development and validation of an LC-MS/MS method for the quantification of novel therapeutic TT-478, a selective adenosine receptor 2B antagonist, for a phase I/II clinical trial #Bioanalysis www.tandfonline.com/doi/full/10....

BioMassSpec

@realbiomassspec.bsky.social

5 months ago

Metabolic alterations in the serum of patients with acute ischemic stroke Ischemic stroke (IS) occurs when a clot obstructs cerebral blood flow, leading to potentially irreversible damage. Metabolites, as the end products of cellular metabolism, can reflect pathological ...

Metabolic alterations in the serum of patients with acute ischemic stroke #Bioanalysis #MassSpec www.tandfonline.com/doi/full/10....

BioMassSpec

@realbiomassspec.bsky.social

6 months ago

Development of a UPLC-MS/MS method for simultaneous quantification of 7 bile acids in feces: application to UC mice Aim: This study aimed to establish a method for the simultaneous quantification of 7 bile acid components in mouse feces and to apply this method to investigate the variations in bile acid profiles...

Development of a UPLC-MS/MS method for simultaneous quantification of 7 bile acids in feces: application to UC mice #Bioanalysis www.tandfonline.com/doi/full/10....

@yuvip.bsky.social

6 months ago

Bioanalytical Testing Services Market Set to Reach USD 12.8 Billion, with a Healthy 7.17% CAGR Till Forecasts 2032 The healthcare landscape in 2025 is poised for a transformative shift, driven by innovation and collaboration

🔬 The Bioanalytical Testing Services Market set to grow to USD 12.8 Bn by 2032 at 7.17% CAGR, advancing precision medicine. 🔗 www.einpresswire.com/article/7768... #Bioanalysis #PharmaServices #Biotech

BioMassSpec

@realbiomassspec.bsky.social

6 months ago

The acute oral toxicity and pharmacokinetic determination of a novel chloroquinoline hybrid molecule by LC-MS/MS CB-1 is a novel compound evaluated in Sprague Dawley rats to assess its acute oral safety and pharmacokinetic disposition.To determine the short-term oral toxicity of CB-1 and characterize its phar...

The acute oral toxicity and pharmacokinetic determination of a novel chloroquinoline hybrid molecule by LC-MS/MS #Bioanalysis www.tandfonline.com/doi/full/10....

BioMassSpec

@realbiomassspec.bsky.social

6 months ago

Correlation between LC-MS/MS and ELISA methods for quantitative analysis of desmosine-containing solutions Desmosine and isodesmosine are crosslinking amino acids found in extracellular matrix protein elastin, which imparts elasticity to tissues such as those of the lungs and arteries. These compounds a...

Full article: Correlation between LC-MS/MS and ELISA methods for quantitative analysis of desmosine-containing solutions #Bioanalysis www.tandfonline.com/doi/full/10....

BioMassSpec

@realbiomassspec.bsky.social

7 months ago

Mass spectrometry for clinical bioanalysis without chromatographic separation: bioequivalence for bupropion and its metabolites High-throughput solid-phase extraction coupled with tandem mass spectrometry (HT-SPE-MS/MS) is an automated sample delivery system to mass spectrometry that operates without chromatographic separat...

Mass spectrometry for clinical bioanalysis without chromatographic separation: bioequivalence for bupropion and its metabolites #Bioanalysis www.tandfonline.com/doi/full/10....