The figure illustrates the different types of tertiary lymphoid structures (TLS) found in tumors. TLS are defined as organized immune aggregates with distinct T and B cell zones, surrounded by peripheral node addressin (PNAd)-expressing high endothelial venules.
(A) Immature or early TLS contain mature dendritic cell lysosomal associated membrane glycoprotein (DC-LAMP)+ dendritic cells (DCs) in the T cell zone.
(B) Within mature TLS, primary follicle-like TLS have in addition T follicular helper (Tfh) cells and CD21+ follicular dendritic cells (FDCs) network allowing T cell immunity activation and low-affinity antibody production.
(C) Secondary follicle-like TLS are characterized by the presence of a germinal center (GC) with B cell lymphoma 6 (BCL6) positive GC B cells, CD21+CD23+ FDC allowing the production of memory B cells and high-affinity antibody secreting plasma cells. Boxes indicate their potential impact on cancer control and on clinical outcome. TCF1, T cell factor 1. Create
#MedSky🧪 #cancerresearch #CellImmunity @cellpress The generation of anti-#tumorimmunity in the draining #lymphnodes is known as ‘the cancer immunity cycle’. Accumulating evidence supports the occurrence of such a cycle at tumor sites in the context of #chronicinflammation.