#Metabolism

U01.01.090 Rate-determining enzymes of metabolic processes A comprehensive review of U01.01.090 Metabolic Pathways. Identify the "bottleneck" enzymes of carbohydrate, lipid, and nucleotide metabolism and the allosteric effectors that control fuel storage versus mobilization.

1 day ago

🚦 The Metabolic Traffic Lights: Master the Rate-Limiting Steps! 🚦
#USMLEStep1 #MedEd #Biochemistry #Metabolism #Enzymes #Step1Prep #HighYield #MedSchool #Endocrinology #Glycolysis #LipidMetabolism #Statins #FutureDoctor #StudyGram

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Estradiol Estradiol (E2; primarily 17β-estradiol and, to a much lesser extent, 17α-estradiol) is the most potent endogenous estrogen and a key regulator of reproductive and metabolic physiology. Beyond its classical role in reproduction, E2 integrates endocrine, paracrine, and intracrine signals to preserve whole-body energy homeostasis. In metabolic tissues, where estrogen receptor α (ERα) is the predominant isoform, E2 regulates glucose and lipid metabolism, mitochondrial function, fuel utilization, inflammation, and cardiometabolic resilience in a sex- and age-dependent manner, contributing to sexual dimorphism.

1 day ago

Online Now: Estradiol #trends #endocrinology #metabolism

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U01.01.089 Enzyme terminology A deep dive into U01.01.089 Enzyme Terminology. Understand the structural components required for enzyme activity, the classification of organic and inorganic cofactors, and the importance of proenzymes in physiological regulation.

1 day ago

🧪 The Language of Catalysis: Mastering Enzyme Terminology! 🧪
#USMLEStep1 #MedEd #MedicalStudent #Biochemistry #Enzymology #Enzymes #Step1Prep #HighYield #MedSchool #Metabolism #ScienceCommunication #FutureDoctor #StudyGram #MedTwitter

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U01.01.088 Ethanol metabolism A deep dive into U01.01.088 Ethanol Metabolism. Understand the biochemical pathways of ethanol clearance, the mechanisms of Fomepizole and Disulfiram, and why chronic alcohol use causes profound shifts in cellular redox states.

1 day ago

🍺 The Metabolic Toll: Mastering Ethanol Metabolism! 🍺
#USMLEStep1 #MedEd #MedicalStudent #Biochemistry #AlcoholMetabolism #Ethanol #Step1Prep #HighYield #MedSchool #LiverHealth #Metabolism #FutureDoctor #StudyGram #MedTwitter

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@ayaaniltd.bsky.social

1 day ago

Prolong your health span. ♻️ From cellular energy and DNA repair to immune support and anti-aging, Ayaani Liposomal NAD+ offers comprehensive benefits for a vibrant life. 👉 www.ayaani.co.uk #Ayaani #NAD #ProlongBenefits #CellularEnergy #DNARepair #ImmuneSupport #AntiAging #Metabolism #vibranthealth

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Glycine (aminoacetic acid) Glycine is mainly produced from serine by serine hydroxymethyltransferase (SHMT1/2) in both the cytoplasm and mitochondria, with additional contributions from threonine, choline, and glycolate metabolism. Functioning as a key metabolic hub, glycine integrates multiple biosynthetic pathways, including one-carbon metabolism and the production of glutathione (GSH), heme, and creatine.

1 day ago

Online Now: Glycine (aminoacetic acid) #trends #endocrinology #metabolism

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American Aging Association

@americanaging.bsky.social

2 days ago

#Aging might be slowed by a metabolic “brake”.
A Nature Aging (2026) study found that PEP acts as an immune checkpoint—reducing chronic inflammation (inflammaging).
It works by inhibiting the cGAS-STING pathway.
#Metabolism = key to aging.
Read:
www.nature.com/articles/s43...

#Longevity #Immunology

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@byteandpieces.bsky.social

3 days ago

You’re Not Losing Fat, You’re Losing YOU: The Dark Side of Ozempic 💉 The Dark Side of the "Miracle Shot": Is Ozempic Melting Your Muscles? Are you trading your long-term vitality for a temporary reflection in the mirror? Most people jumping on the weight-loss medication bandwagon are chasing a number on the scale, but they don't realize they might be burning down their own house just to stay warm. Stay tuned to discover why the "easy way out" might be the hardest on your heart and bones. In this controversial episode, we dive deep into the biological price tag of Ozempic and Mounjaro when used for cosmetic quick fixes. While these drugs are medical breakthroughs for specific conditions, for the casual user, they often trigger a catabolic nightmare that leaves you "skinny fat" and metabolically fragile. 🔍 What’s Really Happening Inside Your Body? When you use GLP-1 agonists without a specific lifestyle strategy, your body doesn't just shed fat—it enters a state of rapid tissue destruction. We are witnessing the rise of the "smaller but weaker" physique, where individuals lose significant muscle mass and bone density in record time. In this episode, we break down: - ⚠️ The Catabolic Trap: Why your body begins destroying itself to fuel the weight loss. - 🔄 The Metabolic Rebound: The science of why users regain fat more easily once the injections stop. - 🛡️ Protective Protocols: Why high-protein diets and heavy resistance training are non-negotiable for anyone on these drugs. - 🌿 Natural Biohacks: How to trigger natural GLP-1 stimulation through fiber and strategic food sequencing for sustainable results. Don't let a pharmaceutical trend dictate your biological future. Whether you're currently using these medications or just curious, this is the essential manual you weren't given for protecting your strength and longevity. 🔥 Ready to reclaim your health the right way? If this episode challenged your perspective, please Rate, Review, and Subscribe! Share this link with someone who needs to hear the truth about the "miracle shot"—it’s time to prioritize your metabolism over a temporary trend! 🚀

📣 New Podcast! "You’re Not Losing Fat, You’re Losing YOU: The Dark Side of Ozempic" on @Spreaker #biohacking #bonehealth #fatloss #fitnessmotivation #foodsequencing #glp1weightloss #healthwarning #highproteindiet #longevity #metabolichealth #metabolism #mounjaro #muscleloss #naturalweightloss

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APNM Journal🏋️🍎

@apnmjournal.bsky.social

4 days ago

Close-up of fresh salmon fillet, eggs, and artichokes beside text about protein recommendations across the lifespan for health and clinical practice.

Submit your research to APNM on topics related to protein intake, performance, aging, and metabolic health to feature in this collection. Submissions close Nov. 30, 2026.

▶️ https://ow.ly/3Q8y50YrtuT

#NutritionResearch #AppliedPhysiology #Metabolism

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BF Francis Ouellette

@bffo.bsky.social

4 days ago

MASH-GA: a manually curated cross-species transcriptomic database for metabolic-associated steatohepatitis Abstract. Metabolic dysfunction-associated steatohepatitis (MASH), formerly called NASH, is a progressive form of fatty liver disease closely linked to met

From #OUP 's #DATABASE journal | MASH-GA: a manually curated cross-species transcriptomic database for metabolic-associated steatohepatitis | #Metabolism #Bioinformatics #Genomics #OpenScience | 🧬 🖥️ 🧪 🔓
⬇️
academic.oup.com/database/art...

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Lipid signaling networks in pancreatic cancer progression and therapeutic perspectives Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers, driven by aggressive biology, profound therapy resistance, and scarce treatment options. Beyond classical metabolic rewiring, recent discoveries reveal that lipid metabolism plays a central and previously underappreciated role in PDAC progression. Emerging evidence shows that fatty acids, cholesterol, lysophospholipids, sphingolipids, and oxidized lipid species actively shape oncogenic signaling, influence stromal and immune interactions, and contribute to metastasis and treatment evasion. In this review, we highlight these recent advances and discuss how lipid-driven circuits intersect with major oncogenic pathways, including KRAS effectors and phosphoinositide 3-kinase–AKT. By integrating mechanistic insights with therapeutic perspectives, we outline new opportunities to exploit lipid-based vulnerabilities in pancreatic cancer.

5 days ago

Online Now: Lipid signaling networks in pancreatic cancer progression and therapeutic perspectives #trends #endocrinology #metabolism

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Flip the fuel, and the heat is on! Carnitine synthesis as a physiological mediator of fuel adaptation To what extent does de novo carnitine synthesis in tissues dictate their fuel preference? Recently, Auger et al. identified Solute Carrier 25A45 (SLC25A45) as a mitochondrial trimethyllysine importer for carnitine biosynthesis. SLC25A45 enables certain tissues to constitutively utilize fatty acids as fuel and, upon bioenergetic crisis, mediates a fuel switch that restores homeostasis.

5 days ago

Online Now: Flip the fuel, and the heat is on! Carnitine synthesis as a physiological mediator of fuel adaptation #trends #endocrinology #metabolism

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Shefali

@iamshef.bsky.social

5 days ago

Really cool new paper from the Rewtiz lab in @natureportfolio.nature.com on how #cholesterol sensing by nuclear receptor HR3 mediates #mTor signaling (via mechanisms possibly independent of its transcriptional function) by acting upstream of RAG GTPase to regulate growth.
#Drosophila #metabolism

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Substrate supply, compartmentation, and utilization in hepatic de novo lipogenesis Hepatic de novo lipogenesis (DNL) is a fundamental process that supports energy storage, membrane biogenesis, and lipid signaling. However, chronically elevated hepatic DNL is a risk factor for insulin resistance and liver fat accumulation. If sustained, this can drive inflammation and fibrosis, with progression to cirrhosis and sometimes hepatocellular carcinoma, as well as numerous cardiometabolic comorbidities. Therefore, new discoveries on the basic mechanisms that control hepatic DNL may enable therapeutic modulation that improves major health outcomes. This review synthesizes recent advances in how the liver channels lipogenic substrates through mitochondrial and cytosolic pathways into DNL. It also highlights how these substrates regulate lipogenic flux by supplying cytosolic acetyl-CoA and NADPH.

5 days ago

Online Now: Substrate supply, compartmentation, and utilization in hepatic de novo lipogenesis #trends #endocrinology #metabolism

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FOODNOURISH.NET

@foodnourish.bsky.social

6 days ago

The Hidden Impact of Light on Your Mitochondria In today's episode we're investigating how modern environments, specifically light bulbs, impact your cellular health. Dr. Andrew Huberman highlights that incandescent bulbs emit long wavelengths that "charge" your mitochondria and improve vision, while common LEDs may damage them. We dive into the "Cell Danger Response," where cells enter a defensive survival mode and stop producing energy. Chronic illness can occur when this healing cycle gets stuck, causing systemic dysfunction and fatigue. Restoring health requires shifting cellular signaling from danger to safety through restorative sleep and natural light. References: - https://www.vigilantfox.com/p/leading-neuroscientist-says-this Support our work. Make a small donation. This removes any advertisements and help us continue bringing more interesting topics and confronting mainstream narrative on health. Click the Link to support us: https://www.spreaker.com/podcast/foodnourish-deep-dives--6602003/support

📣 New Podcast! "The Hidden Impact of Light on Your Mitochondria" on @Spreaker #atp #biohacking #cells #cellular #chronic #energy #healing #health #incandescent #inflammation #led #light #metabolism #mitochondria #recovery #signaling #stress #survival #vision #wellness

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@healtvisionusa.bsky.social

6 days ago

Glucore helps support balanced blood sugar levels, improve metabolism, and boost daily energy. Its natural formula promotes overall wellness and helps maintain a healthier lifestyle.
Order Now :- eng-eng-glucore.com

#Glucore #BloodSugarSupport #GlucoseControl #EnergyBoost #Metabolism #HealthyLife

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A new era in childhood obesity Advances in our understanding of hypothalamic control of energy homeostasis have resulted in the identification of genetic forms of obesity, both syndromic and nonsyndromic, with some precision treatments now being employed. In this review article, we examine the progress being made in identifying new genes involved in the hypothalamic leptin–melanocortin system and their possible implications in obesity, as well as other potential clinical features. We include an update on clinical trials in genetic obesity with specific pharmacological treatments, such as agonists for the melanocortin 4 receptor, and for glucagon-like peptide-1 receptor. The possibility of employing new precision drug targets in specific forms of obesity is modifying the approach to disease treatment in the pediatric clinic.

6 days ago

Online Now: A new era in childhood obesity #trends #endocrinology #metabolism

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Stefano Bettinazzi

@stefanobettinazzi.bsky.social

6 days ago

Metabolic consequences of naturally occurring mitochondrial heteroplasmy in bivalves Abstract. Oxidative phosphorylation, the cornerstone of mitochondrial energy production, is a tightly regulated process that relies on the strict interacti

Our latest study on mitochondrial heteroplasmy and its impact on energy metabolism across sexes is finally out in ProcB @royalsocietypublishing.org!! 🎉🦪🧬

Kudos to Ariane and the Breton Lab for this marvellous work.
#mitochondria #heteroplasmy #metabolism

Check it out!

doi.org/10.1098/rspb...

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Sable Systems

@sablesys.bsky.social

6 days ago

An IL6 variant -174 G-C alters cardiac hypertrophy but not cardiometabolic responses to HFD in mice - npj Metabolic Health and Disease npj Metabolic Health and Disease - An IL6 variant -174 G-C alters cardiac hypertrophy but not cardiometabolic responses to HFD in mice

How do genetic variants of #interleukin-6 (#IL6) contribute to #cardiometabolic disease? With help from Promethion #Metabolic Cages, scientists tested a knock-in mouse model of the IL6 promoter variant #rs1800795. 🧪

buff.ly/GDBusEN

#Respirometry #Metabolism #CVD #HFD

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Sable Systems International

@sablesystems.bsky.social

6 days ago

An IL6 variant -174 G-C alters cardiac hypertrophy but not cardiometabolic responses to HFD in mice Chronic elevations in interleukin-6 (IL6) signaling have been shown to exacerbate features of cardiometabolic disease. A common variant in the IL6 promoter (location -174 G/C, identifier rs1800795) is...

How do genetic variants of #interleukin-6 (#IL6) contribute to #cardiometabolic disease? With help from Sable Promethion #Metabolic Cages, scientists tested a knock-in mouse model of the IL6 promoter variant #rs1800795.

buff.ly/GDBusEN

#Respirometry #Metabolism #Inflammation #Adipose #CVD #HFD

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The immunoregulatory role of progesterone during embryo implantation and pregnancy Progesterone (P4), the ‘pregnancy hormone’, plays a pivotal role in the establishment and maintenance of pregnancy by modulating maternal immune responses, thereby promoting immune tolerance toward the semi-allogeneic fetus. In this review, we examine the key pathways through which P4 mediates its effects on maternal immune systems. We elucidate P4's immunomodulatory functions, with a focus on how altered P4 signaling may affect immune tolerance toward the fetus and contribute to the pathogenesis of pregnancy complications. We further discuss the potential role of P4 supplementation in improving embryo implantation and preventing miscarriage, as well as its role in modulating immune-mediated pathological conditions during pregnancy, while emphasizing unresolved questions and directions for future investigation.

6 days ago

Online Now: The immunoregulatory role of progesterone during embryo implantation and pregnancy #trends #endocrinology #metabolism

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U01.01.079 Vitamin B7 Test your knowledge of U01.01.079 Vitamin B7. Practice identifying the "ABC" enzymes of biotin-dependent carboxylation and the clinical triad of dermatitis, alopecia, and enteritis with this expert-curated MCQ set.

6 days ago

🥚 The Carboxylation Key: Mastering Vitamin B7 (Biotin)! 🥚Biotin is the essential carrier of activated carbon dioxide ($CO_2$) for the body's carboxylation reactions. #USMLEStep1 #MedEd #MedicalStudent #Biochemistry #VitaminB7 #Biotin #Step1Prep #HighYield #MedSchool #Metabolism #Gluconeogenesis #N

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Lawrence Kazak

@kazaklab.bsky.social

6 days ago

I’m thrilled to co-organize the 2nd #AdiposeBiology with @sunglab.bsky.social, Jacqueline Beaudry, and @sablesys.bsky.social in Montreal on Oct 7-9 2026!🇨🇦
🔗 Register now – adiposebiology.com
Hope to see you there! #ABC2026 #Metabolism #Energybalance #ObesityResearch @mcgillgci.bsky.social

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Journal of Experimental Medicine

@jem.org

6 days ago

Who gets the calories? An endothelial checkpoint for fat expansion. Luisa Iruela-Arispe @feinberg.northwestern.edu discusses new work by Wetternwald, Köck and colleagues @petrovalab.bsky.social (rupress.org/jem/article/...) in Insights: rupress.org/jem/article/...

#CardiovascularBiology #Metabolism

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