Using matched WBC and platelet RNA-seq from MPN patients, we identify myelofibrosis-associated transcriptomic signatures specifically enriched in platelets. Multinomial LASSO modeling highlights platelet-derived gene expression as a dominant and predictive biomarker of myelofibrosis, outperforming clinical parameters and WBC signatures.
Happy to share a preprint here (bit.ly/4c6yECo) - years in the making that asks a deceptively simple question: when it comes to reading #MPN disease from peripheral blood, do #platelets or white blood cells tell us more?
Details:
bit.ly/4caanLT
Thanks for your read!
#MPN #platelet #WBC #RNAseq