#aptamer

3D Protein Imaging

@proteinimaging.bsky.social

1 week ago

Here you can see a crystal structure of a RNA aptamer bound to vitamin B12 (PDB code: 1DDY)

Rendering by Francisco J. Enguita made with #ProteinImager

3dproteinimaging.com/protein-imag...

#SciArt #molecularart #rna #aptamer #binding #vitamin #b12 #xray

Bussi Lab

@bussilab.org

1 month ago

Together, the work defines how an RNA #aptamer integrates metal and proton cues for combinatorial environmental sensing.

Signal Transduction and Targeted Therapy

@sigtrans-sttt.bsky.social

1 month ago

Broad-spectrum nucleocapsid-targeting #aptamer NApt8-3 blocks N protein–NLRP3 #inflammasome signaling to suppress #coronavirus inflammation; its trivalent chimera circSASON enhances delivery, reducing #SARSCoV2 replication & lung inflammation in mice.

#STTT: doi.org/10.1038/s413...

One Health Advances

@onehealthadv.bsky.social

1 month ago

🧃 Patulin (PTL) is a dangerous mold toxin commonly found in fruit products. 🍎This study presents an innovative solution for its detection.🎯

📊 Read more: link.springer.com/article/10.1...

#FoodSafety #Aptamer #Mycotoxin #PatulinDetection

michael

@proseandpassion.mastodon.social.ap.brid.gy

2 months ago

aptamer sensors patched up My astrobiology co-author Kevin Plaxco has been pioneering the development of biosensors based on aptamers (the artificially generated DNA equivalent of antibodies) for many years now and every once in a while I write about the progress in this fascinating field. Now the work has reached its first clinical trial, so I wrote a news story for Chemistry World to help spread the word. The news story is out now: World first for clinical trial of skin patch to monitor therapeutic drugs in real time Chemistry World 5.2.2026 Source: © Marsilea A Booth et al/Springer Nature America 2026 Previous episodes in this serie are listed here.

first #clinicalTrial for #aptamer sensors enabling continuous #monitoring of therapeutic drugs in vivo - my news story in #ChemistryWorld out now: proseandpassion.blogspot.com/2026/02/aptamer-sensors-...

#science #medical #technology #diagnostics

Schwalbe Lab

@schwalbe-lab.bsky.social

3 months ago

Crystal structure of the class V GTP-binding RNA aptamer bound to its ligand: GTP recognition by a topologically complex intermolecular G-quadruplex Abstract. RNA aptamers obtained from in vitro selection experiments provide unique insights into the structural properties and ligand recognition capabilit

Check out the newest publication of the Wöhnert lab! ☺️
"Crystal structure of the class V GTP-binding RNA aptamer bound to its ligand: GTP recognition by a topologically complex intermolecular G-quadruplex"

Full text: academic.oup.com/nar/article/...

#G4 #X-ray #aptamer #NAR

Rian Nejar 🦋

@riannejar.bsky.social

3 months ago

Microscope view of senescent cells among healthy ones tagged by an aptamer (in blue) - Mayo Clinic study

Identifying senescent "zombie" cells among healthy ones [via Mayo Clinic] 🧪🥼⚕️🧟🦠👈

"aptamers are a technology that can be used to distinguish senescent cells from healthy ones,"

newsnetwork.mayoclinic.org/discussion/a...

#cell #zombie #disease #aging #aptamer #tagging

Molecular Therapy Family of Journals

@moltherapy.bsky.social

4 months ago

Molecular Therapy Presents: Innovations in Aptamer Technology In 1990, two seminal studies introduced a novel method, systematic evolution of ligands by exponential enrichment (SELEX), to discover and isolate…

NEXT WEEK: #MolecularTherapy Presents webinar, Innovations in Aptamer Technology (December 4 at 1 PM CST). Come learn about the most cutting-edge applications of aptamers. Register here today: http://dlvr.it/TPRPt3
#aptamer

Nature Nanotechnology

@natnano.nature.com

10 months ago

Evolution of multivalent supramolecular assemblies of aptamers with target-defined spatial organization - Nature Nanotechnology Expanding aptamer binder space through tunable directed coevolution of supramolecular scaffolds helps discover nucleic-acid-based multivalent target binders capable of synergistic engagement that cann...

New paper online:

Evolution of multivalent supramolecular assemblies of aptamers with target-defined spatial organization.

"Expanding #aptamer binders via tunable directed #coevolution enables discovery of multivalent target binders."

www.nature.com/articles/s41...

#MolecularSelf-assembly

Inorganic Chemistry Frontiers

@inorgchemfront.rsc.org

10 months ago

A DNA aptamer for trivalent lanthanide ions with low nanomolar affinity Lanthanides are extremely important for a variety of technological applications. In this work, DNA aptamers were selected using the library-immobilization method (capture-SELEX) with Tb3+ and Ce3+ as ...

🔓Check out recent #OpenAccess research -- A DNA #aptamer for trivalent #lanthanide ions with low nanomolar affinity
🧪 #Chemsky #ICF_research #Inorganic
doi.org/10.1039/D5QI...

Thiard News@F4F

@newsen.bsky.social

11 months ago

Ajinomoto and RIBOMIC Join Forces to Enhance Aptamer Pharmacokinetics Using Innovative Technology The collaboration between Ajinomoto and RIBOMIC focuses on extending the pharmacokinetics of nucleic acid aptamers to improve drug efficacy, promising new advancements in pharmaceuticals.

Ajinomoto and RIBOMIC Join Forces to Enhance Aptamer Pharmacokinetics Using Innovative Technology #Japan #Tokyo #Ajinomoto #RIBOMIC #Aptamer

A Chronic Voice

@achronicvoice.com

11 months ago

A Breakdown Of The Latest Research On Antiphospholipid Syndrome. (Two people dressed casually discuss in the background. One takes notes and the other holds onto an ipad.)

"In relation to #AntiphospholipidSyndrome and its potential complications, a new #DNA drug to fight #BloodClots has been discovered..the anti-thrombin DNA #aptamer, M08s-1, might act as a promising antidote for HIT (heparin-induced #thrombocytopenia)": buff.ly/PcOZ0mr

Ana Díaz Fernández

@anadfdez.bsky.social

11 months ago

Refinement and Truncation of DNA Aptamers Based on Molecular Dynamics Simulations: Computational Protocol and Experimental Validation Aptamers have proven useful for a wide variety of applications, such as drug delivery systems and analytical reagents for diagnosis or food safety control. Conventional aptamer selection methods typic...

Happy to see this paper out🎉
Here, we introduce APTAMD, an online tool for predicting the 3D structure of an #aptamer from its sequence. APTAMD is a powerful tool for post-SELEX optimisation.
Free to download👇
github.com/dimassuarez/...
#Bioinformatics #SELEX
pubs.acs.org/doi/full/10....

Ana Díaz Fernández

@anadfdez.bsky.social

1 year ago

📢Prof. Cecilia Cristea and I are pleased to invite you to contribute to the Special Issue Aptamer-Based Biosensors for Point-of-Care Diagnostics #BiosensorsMDPI 🧬
More info 👉www.mdpi.com/journal/biosensors/speci...
#pointofcare #aptamer #sensors