Latest posts tagged with #ESCC on Bluesky
ZNF750 functions as a #TumorSuppressor in #ESCC by regulating #PUFA metabolism via FADS1, and its loss drives lipid remodeling, malignant progression, and #ferroptosis sensitivity through ACSL4, spotlighting PUFA metabolism and ferroptosis as targets.
Read: doi.org/10.1016/j.ge...
Research demonstrates that dysregulated #Notch signaling promotes #TumorAngiogenesis in #ESCC via the NOTCH1–USP5–STAT3 axis, suggesting that targeting this pathway could inhibit #TumorVascularization and progression.
#STTT #OpenAccess: doi.org/10.1038/s413...
Our challenger for the 2026 European Sports Car Championship - the No. 84 Unitronic Porsche 911 GT3 R (992) GT3LM. We're ready for the new season - Round 1 is on April 25th at Barcelona!
#ESCC #Porsche #RacingGreen #Unitronic #Fanatec #SimRacing
Leads Biolabs Advances Cancer Treatment with Opamtistomig in Clinical Trials #China #Leads_Biolabs #Nanjing #Opamtistomig #ESCC
This study defines four consensus #ESCC subtypes and introduces imECMS, a #DeepLearning image-based classifier validated across cohorts, offering a robust framework for #PrecisionMedicine and targeted therapies in #EsophagealCancer.
#OpenAccess #STTT: doi.org/10.1038/s413...
This large-scale PALACE-2 trial shows that preoperative #pembrolizumab plus #chemoradiotherapy in resectable #ESCC achieved a 43.2% pCR rate, acceptable safety, and one‑year survival over 90%, with #IL6 identified as a predictive #biomarker.
#OpenAccess in #STTT: doi.org/10.1038/s413...
JUPITER-06 Final Overall Survival and Genomic Biomarker Analysis in Advanced ESCC
oncodaily.com/new-paper-al...
#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #JUPITER-06 #ESCC
Microbial dysbiosis may play a key role in ESCC etiology, offering potential pathways for earlier detection and more targeted treatment strategies. Research is early, but promising.
#Oncology #Microbiome #CancerResearch #ESCC #EsophagealCancer
Esophageal squamous cell carcinoma (ESCC) accounts for over 90% of esophageal cancer cases in China and still carries a 5‑yr survival rate under 30%. A review highlights an emerging factor in its development: the oral & esophageal microbiota.
🔗 buff.ly/rhqta16
#ESCC
Using #MassCytometry, this #STTT study characterized the #ImmuneLandscape of #ESCC, demonstrating that targeting CD39⁺ T cells & PD-L1⁺ macrophages can reprogram the #TumorMicroenvironment to optimize #Immunotherapy response.
#OpenAccess: doi.org/10.1038/s413...
Entry confirmed! 🔥
We are excited to announce that we will be competing in the 2026 ESCC season with our #10 LMP2 entry.
#iRacing #SimRacing #P1Racing #LapsDownRange #ESCC
Mechanistic insights into how HMGB3 drives proliferation & #metastasis in #ESCC via the TGIF2/HMGB3/TLR3/TGF-β signaling axis associated with poor patient prognosis, positioning this axis as a promising #TherapeuticTarget.
#OpenAccess: doi.org/10.1016/j.ge...
We're excited to announce our #84 Porsche 911 GT3 R (992) will return to the European SportsCar Championship for the 2026 season, in the LMGT3 class!
#ESCC #Simracing #RacingGreen #Porsche
📢 Real-world evidence
First-line pembrolizumab + chemo shows strong effectiveness and safety in advanced/recurrent ESCC:
✅ ORR: 60.9%
✅ Median OS: 17.3 months
Paclitaxel + platinum emerges as the best partner.
🔗 buff.ly/wb9uUJT
#ESCC #Immunotherapy #Oncology #RealWorldData
The FAK/Src kinase axis drives #MetabolicReprogramming by activating ACLY and ALDOA, which induce CDK7/9-mediated expression of DNA-replication and proliferation genes in primary and metastatic #ESCC cells. @pku1898.bsky.social
#STTT #OpenAccess: doi.org/10.1038/s413...
#DNADamageResponse protein, KIN, drives #ESCC progression by clearing R-loop–associated #DNAdamage, while KIN depletion triggers NFκB–STING activation, improves the #TumorImmuneMicroenvironment, and enhances #immunotherapy response.
#OpenAccess in #STTT: doi.org/10.1038/s413...
This study proposes FU-ESCC subtyping, a #prognosis-related molecular classification system that defines three #ESCC subtypes with distinct molecular and clinical features, enabling patient stratification for personalized treatment. #medsky
#STTT #OpenAccess: doi.org/10.1038/s413...
It's a wrap! In the 2025 season finale of the @escc_acv in Portimão, Aaron Beaver and Connor Botting run in the top three early on, but a series of incidents relegate our #84 Porsche 911 GT3R to an eighth place finish in a tough race. #ESCC #Portimao #Porsche #RacingGreen
#CyTOF generated #SingleCellAtlas offers insights into the immune landscape of #ESCC, revealing a complex interplay of immune cell types and states, and provides a framework for patient stratification and designing #Immunotherapy combinations.
#OpenAccess: doi.org/10.1038/s413...
Lenvatinib Plus Pembrolizumab and Chemotherapy Fails to Improve OS in Advanced #ESCC #ESMO25 #oncology
www.onclive.com/view/lenvati...
SKYSCRAPER-07 at ESMO 2025: Tiragolumab Plus Atezolizumab After dCRT in Locally Advanced ESCC
@myesmo.bsky.social
oncodaily.com/oncolibrary/...
#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #ESMO #ESMO25 #ESMO2025 #ESCC #SKYSCRAPER07 #Tiragolumab #Atezolizumab #GIOnc
In #ESCC, aberrant #NotchSignaling promotes #TumorAngiogenesis through the NOTCH1–USP5–STAT3 axis, with #USP5 stabilizing #STAT3 to enhance pro-angiogenic factors, and targeting USP5 alongside #chemotherapy suppresses tumor growth.
#OpenAccess #STTT: doi.org/10.1038/s413...
Round 5 of the ESCC on Sep 13th turned out to be a tough one for our #84 Porsche 911 GT3 R. A car contact with penalty on lap 1, another incident later with damage, it's P11 for Aaron Beaver and Benjamin Fischer on a foggy day at Silverstone. #ESCC #Silverstone #Porsche #RacingGreen
The FAK/Src family kinase axis contributes to #MetabolicReprogramming by inducing the phosphorylation of ATP-citrate synthase and fructose-bisphosphate aldolase A, to promote #metastasis in #ESCC cells. #medsky @pku1898.bsky.social
#OpenAccess:
This study identifies KIN as a novel R-loop binding protein in #ESCC, that promotes DNA damage clearance and #ImmuneEvasion, while its depletion triggers R-loop accumulation and STING–NFκB–mediated immune activation. #DNADamageResponse
#STTT #OpenAccess:
This review offers insights into the advantages of #Organoids in #ESCC disease modelling, as well as their exciting potential when combining with gene editing for personalized treatment strategies. #PersonalizedMedicine #medsky
#OpenAccess:
www.sciencedirect.com/science/arti...
Aaron Beaver and Benjamin Fischer in our #84 Porsche 911 GT3 R (992) earn fourth place in the @escc_acv 4 Hours of Spa-Francorchamps! The race was marred by a number of safety car periods, but the team stayed on course to tie its season-best result so far. #ESCC #Spa #Porsche #RacingGreen
There are a few easy wins to help ease the problem through #Newhaven but #EastSussexCountyCouncil aren’t interested.
#ESCC #Sussex
We’ve already had one here in #EastSussex
But we know #ESCC just pays lip service to consultations, the decisions are already made - we know from experience:
#Newhaven incinerator - 16,000+ objections (it was built!)
Recycling Centres booking system - 90% of respondents objected (it’s going ahead!)
