#LdL

JAMA

@jama.com

3 hours ago

Line graph titled 'Cost-Effectiveness of text@1, Non-HDL-C, and LDL-C Goals for Primary Prevention Lipid-Lowering Therapy'. The graph shows cost-effectiveness acceptability curve with 'Optimal probability strategy, %' on the Y-axis and 'Cost-effectiveness threshold (2025 $/QALY gained)' on the X-axis. Lines represent ApoB goal, Non-HDL-C goal, and LDL-C goal.

A computer simulation found #ApoB-guided intensification of lipid-lowering therapy provides the most QALYs and is highly cost-effective compared to #LDL-C or #nonHDL-C targets.

ja.ma/4cxfzKX

Fazen Capital

@fazencapital.bsky.social

1 week ago

Merck Enlicitide Lowers LDL vs Non-Statins Merck's enlicitide showed ~38% LDL reduction vs ~11% for non-statins (Mar 30, 2026 report); the oral PCSK9 candidate could broaden treatment but faces regulatory and payer hurdles.

Merck Enlicitide Lowers LDL vs Non-Statins: Merck's enlicitide showed ~38% LDL reduction vs ~11% for non-statins (Mar 30, 2026 report); the oral PCSK9 candidate could broaden treatment but faces regulatory and payer hurdles. 👈 Read full analysis #Merck #Enlicitide #LDL #PCSK9 #Cholesterol

A Chronic Voice

@achronicvoice.com

2 weeks ago

Your Cholesterol Numbers: The Good, the Bad, the Triglycerides A Yale Medicine cardiologist explains how to understand your cholesterol screening numbers.

“The primary reason to check #cholesterol in #children is to identify familial #hypercholesterolemia (FH), an inherited defect in the body’s recycling of #LDL cholesterol..impt to identify that #genetic cholesterol problem & treat it early.": buff.ly/rL3v0p5

from @yaleschoolofmed.bsky.social
#genes

Elena Sgarbossa MD

@elenasgarbossamd.bsky.social

3 weeks ago

And, always tell patients that we humans have 0 need to eat cholesterol. We synthesize it. We’re healthier when we eat exclusively plants & mushrooms 🌱🍄

… and may never need to worry about our LDL-c levels 😎

#ApoB #HeartDisease #cardiology #prevention #CVD #HDL #LDL #Cholesterol #diet #itsTheDiet

Nature Medicine

@natmed.nature.com

1 month ago

In a phase 1 trial with 6 patients, #lipid nanoparticles for #PCSK9 base editing lowered #LDL without serious adverse events or off-target effects. https://www.nature.com/articles/s41591-026-04254-4

Sallythechin

@sallythechin.bsky.social

1 month ago

Praxishandbuch Lernen durch Lehren Lernen durch Lehren (LdL) ist ein in den 1980ern von Jean-Pol Martin entwickeltes Lern-Lehr-Konzept, bei dem Lernende schrittweise die Rolle der Lehrkraft einnehmen. LdL-Anwender*innen berichten von m...

Erinnert mich spontan an #LdL oder @vilsrip.bsky.social 🤗? www.beltz.de/fachmedien/p...

Hunteress

@hunteress.eurosky.social

1 month ago

Warum Haferflocken den Cholesterinspiegel schon nach zwei Tagen senken können Gerade einmal zwei Tage – so kurz kann es dauern, bis sich der Cholesterinspiegel messbar verbessert. Entscheidend sind Haferflocken, die fast jeder im Schrank hat.

#Haferbrei anyone? #Was die kurze #Haferkur mit #LDL #Cholesterin #Vorbeugung von #Diabetes und #Mikrobiom zu tun hat 👇❗❗❗

www.t-online.de/gesundheit/a...

A Chronic Voice

@achronicvoice.com

1 month ago

Your Cholesterol Numbers: The Good, the Bad, the Triglycerides A Yale Medicine cardiologist explains how to understand your cholesterol screening numbers.

“Because Lp(a) is #genetic, people can have high levels even with normal #LDL ..A screening must be ordered separately from the typical #lipid panel and is only required once in a lifetime.”: buff.ly/wDzuymF

from @yaleschoolofmed.bsky.social
#HeartHealth #HighCholesterol #cholesterol #MedSky

Current Medical Science

@currentmedscience.bsky.social

1 month ago

Research Progress on the Pathogenesis and Treatment of Neoatherosclerosis

This review defines #neoatherosclerosis as a distinct in-stent pathology driven by oxidized lipids and #VSMC foam cells, stressing endothelial injury, #inflammation, and need for strategies beyond #LDL reduction to prevent #restenosis. @2024_HUST #stent
Read: doi.org/10.1007/s115...

Dr. Balaram Dhotre, Ph.D.

@drbalaramdhotre.bsky.social

1 month ago

DrBalaram Dhotre on Instagram: "✨ What's YOUR Opinion on Lowering Cholesterol? ✨ I believe that lowering cholesterol is about more than just numbers. It's about repairing the arteries and improving ... 3 likes, 0 comments - coach_drbalaramdhotre on April 9, 2025: "✨ What's YOUR Opinion on Lowering Cholesterol? ✨ I believe that lowering cholesterol is about more than just numbers. It's about repair...

✨ What's YOUR Opinion on Lowering Cholesterol? ✨
I believe that lowering cholesterol is about more than just numbers.
#cholesterol #hearthealth #lifestyle #supplements #vitamins #lpa #ldl #health #wellness #askmeanything
www.instagram.com/p/DIO6hUoz_pj/

Dr. Balaram Dhotre, Ph.D.

@drbalaramdhotre.bsky.social

1 month ago

Do ldl Levels Increase or Does Artery Damage Occur? When it comes to heart health, most people think ldl levels increase first and cause artery damage. But is that really how it happens?

🎉What Happens First: Do LDL Levels Increase or Does Artery Damage Occur?

Read the complete article here:
lyproc.com/what-happens...

#ldl #ldlincrease #highcholesterol #lpa #arterydamage #atherosclerois #heartdiseasereversal #drbalaramdhotre

Sue Petersen

@healthsimple.bsky.social

2 months ago

Heart health isn’t built in a doctor’s office. It’s built in your kitchen. What you eat everyday matters more than one visit or one prescription.

Your kitchen is powerful.

#healthsimple #ldl #LDLcholesterol

Elena Sgarbossa MD

@elenasgarbossamd.bsky.social

2 months ago

Best diet for health, and possibly longevity? 😎
.
A whole foods plant-based diet 🍅🫑🥗🍄‍🟫🥑🍠🥕🍆🫛🥔🥬🫜🥒🍝🍓🫐🥝🍑🍎

Why not go vegan today? 💪🏻

#health #diet #ItsTheDiet #cholesterol #LDL #cardiology #nutrition #WFPB #vegan

Lipodystrophy United

@lipodystrophyunite.bsky.social

2 months ago

High LDL (cholesterol) can be a big issue in lipodystrophy — but there are multiple paths to lowering it.
• Lifestyle foundations
• Statins (and why tolerance varies)
• Non-statin options like ezetimibe, PCSK9 inhibitors, and bempedoic acid
#Lipodystrophy #RareDisease #Cholesterol #LDL

The Lancet Diabetes & Endocrinology

@thelancetendo.bsky.social

2 months ago

Efficacy and safety of inclisiran in adolescents with heterozygous familial hypercholesterolaemia (ORION-16): a two-part, randomised, multicentre clinical trial In adolescents with HeFH, inclisiran was effective in lowering LDL cholesterol, with sustained efficacy over 2 years, and was well tolerated. These results support inclisiran as a potentially useful a...

In this adolescent patient population with #HeFH and elevated #LDL #cholesterol despite standard of care, inclisiran was effective in lowering LDL cholesterol, showing sustained efficacy over 2 years of treatment, with a reduction of −33·7% from baseline at day 720 www.thelancet.com/journals/lan....

American Journal of Preventive Cardiology

@ajpcardio.bsky.social

3 months ago

New US physician survey identifies barriers and burdens in optimizing LDL-C management, revealing key challenges clinicians face in practice.

🔗 https://ow.ly/Lx4R50XSfpf

#LDL #Cholesterol #PreventiveCardiology #HeartHealth #CardioResearch #CardioSky #MedSky

Sustain Health Magazine

@sustainhealth.bsky.social

3 months ago

New research links festive drinking and rich food to higher LDL; these four resolutions help you recover fast.

#cholesterol #JanuaryReset #LDL #newyear
sustainhealth.fit/lifestyle/ld...

The Lancet Diabetes & Endocrinology

@thelancetendo.bsky.social

3 months ago

Does siRNA therapy against ANGPTL3 bring new hope in homozygous familial hypercholesterolaemia? Homozygous familial hypercholesterolaemia is a rare and devastating autosomal co-dominant disorder affecting between one in 160 000 and 300 000 people in the general population.1 Homozygous familial h...

Linked Comment by Raul D Santos:
Does siRNA therapy against ANGPTL3 bring new hope in #homozygous #familial #hypercholesterolaemia? www.thelancet.com/journals/lan...
#zodasiran #HoFH #LDL #cholesterol

#MedSky #EndoSky #CardioSky

The Lancet Diabetes & Endocrinology

@thelancetendo.bsky.social

3 months ago

Zodasiran, an RNAi therapeutic targeting ANGPTL3, for treating patients with homozygous familial hypercholesterolaemia (GATEWAY): an open-label, randomised, phase 2 trial Quarterly dosed zodasiran shows evidence of reductions in LDL cholesterol with a favourable safety profile, in patients with HoFH receiving background lipid-lowering therapy. Further investigation in ...

Quarterly dosed #zodasiran shows evidence of reductions in #LDL #cholesterol with a favourable safety profile, in patients with #HoFH receiving background lipid-lowering therapy www.thelancet.com/journals/lan...
#homozygous #familial #hypercholesterolaemia

#MedSky #EndoSky #CardioSky

FOODNOURISH.NET

@foodnourish.bsky.social

3 months ago

The Buried Truth About High Cholesterol and Heart Disease In today's episode we're challenging the belief that cholesterol is the main cause of heart disease. Did you know 75% of heart attack patients have "normal" cholesterol levels? We dive into 50 years of buried data, including the Minnesota Coronary Experiment, which showed that lowering cholesterol didn't always save lives—it even increased death risk in some cases. We explore why insulin resistance and inflammation are the real culprits, the side effects of statins, and why your body needs cholesterol for brain health. Learn the markers that truly matter. References: https://foodnourish.net/high-cholesterol-and-heart-disease-myth-or-truth/ Become a supporter for just 2€ per month. This removes any advertisements and help us continue bringing more interesting topics and confronting mainstream narrative on health. Link to support: https://www.spreaker.com/podcast/foodnourish-deep-dives--6602003/support

📣 New Podcast! "The Buried Truth About High Cholesterol and Heart Disease" on @Spreaker #arteries #biology #cholesterol #diet #disease #fat #hdl #health #heart #inflammation #insulin #ldl #metabolism #nutrition #plaque #science #statins #sugar #triglycerides #wellness

Echoes of Arcana

@johntristan.bsky.social

3 months ago

LDL 콜레스테롤 수치가 높으면 위험할까? 최신 연구와 나토키나제의 효능 LDL 수치가 높으면 무조건 위험할까요? 2025년 최신 연구 결과와 LDL 상승의 진짜 원인, 그리고 혈관 플라크 감소에 효과적인 나토키나제에 대한 정보를 확인하세요. 수치 너머의 진짜 혈관 건강 관리법을 소개합니다.

LDL 콜레스테롤 수치가 높으면 위험할까? 최신 연구와 나토키나제의 효능 #콜레스테롤 #LDL #나토키나제

건강검진에서 높은 LDL 콜레스테롤 수치를 보고 걱정하셨나요? 2025년 최신 연구는 LDL 수치만으로 심장질환 위험을 판단하는 것에 의문을 제기합니다. 단순히 수치를 낮추는 것보다 중요한 '원인' 파악과 혈관 플라크 감소에 도움을 주는 나토키나제(Nattokinase)의 효능까지, 혈관 건강의 진실을 정리했습니다.

A Chronic Voice

@achronicvoice.com

3 months ago

Your Cholesterol Numbers: The Good, the Bad, the Triglycerides A Yale Medicine cardiologist explains how to understand your cholesterol screening numbers.

“ #Lipoprotein (a), or Lp(a), is a sticky, genetically inherited form of bad #cholesterol that contains #LDL. “Over the last decade, we’ve learned that Lp(a) is an independent risk factor for #HeartDisease & #stroke,” Dr. Giaimo says.”: buff.ly/7AbHGU7

from @YaleMed.bsky.social

Echoes of Arcana

@johntristan.bsky.social

3 months ago

LDL 수치가 높아도 심혈관 질환 위험이 낮을까? 대사적으로 건강한 고콜레스테롤혈증 임상 사례 및 분석 LDL 수치가 높아도 심혈관 위험이 없을 수 있습니다. 운동선수와 LCHF 실천자의 임상 사례를 통해 수치보다 중요한 인슐린 저항성과 염증 지표를 분석합니다. 숫자의 공포에서 벗어나 내 몸의 진짜 대사 건강을 확인하는 통합적 접근법을 지금 확인하세요.

LDL 수치가 높아도 심혈관 질환 위험이 낮을까? 대사적으로 건강한 고콜레스테롤혈증 임상 사례 및 분석 #콜레스테롤 #LDL

건강검진에서 LDL 콜레스테롤 수치가 높게 나왔지만, 꾸준한 운동과 저탄수화물 고지방(LCHF) 식단을 유지하며 건강함을 느끼고 계신가요? 단순히 수치만 보고 불안해하거나 즉각적인 약물 치료를 고민하기 전에, 대사 건강의 전체적인 맥락을 파악하는 것이 중요합니다. 최근 임상 사례들은 마라톤 선수나 엄격한 식단 관리를 하는 사람들에게서 나타나는 높은 LDL 수치가 병리적 현상이 아닌, 효율적인....

Lipodystrophy United

@lipodystrophyunite.bsky.social

3 months ago

Did you know that lipodystrophy affects how the body processes fat and cholesteromaking LDL harder to manage?
Diet is one piece of the puzzle, but personalized medical care is essential#RareDiseaseAwareness #Lipodystrophy #LDL #MetabolicCare #Lipodystrophyunited

M. Bilal Ahmed, MD, MBA

@brwnmgk.bsky.social

3 months ago

Ex: Autopsies of Egyptian mummies, showed narrowing in the arteries of 38% of 54 mummies, including teenagers. A lifetime of avoiding risk factors means cumulative change you can protect yourself before it's too late

#Prevention #PreventativeHealth #LDL #Cardiology #HeartHealth #Inflammation

Molecular Biomedicine

@mol-biomed.bsky.social

4 months ago

Computer-aided design enables repurposing of proprotein convertase subtilisin/kexin type 9 degrader from cholesterol-lowering to colon cancer therapy - Molecular Biomedicine Molecular Biomedicine -

#Letter
omputer-aided design enables #repurposing of proprotein convertase subtilisin/kexin type 9 degrader from #cholesterol-lowering to colon #cancer therapy doi.org/10.1186/s435...

#ColorectalCancer #CRC #PCSK9 #LDL #LDLR #EMT

Don Porqué

@donporque.bsky.social

4 months ago

¿Funciona la pastilla que promete peso ideal y corazón sano? Polipíldora CNIC, LDL bajo y semaglutida 2,4 mg: qué hay tras la superpíldora que protege corazón y reduce peso con evidencia clínica sólida La respuesta honesta cabe en dos frases. No existe, a día d...

¿Funciona la pastilla que promete peso ideal y corazón sano? #Cardiología #Salud #Colesterol #LDL #Obesidad #Semaglutida #Polipíldora #CNIC #PrevenciónCardiovascular #Aterosclerosis #GLP1 #4dediciembre #felizjueves donporque.com/pastilla-pes...

Drugs in Context

@drugsincontext.bsky.social

4 months ago

💊 Deferiprone therapy improves the oxidative status of LDL in patients with β-thalassaemia/HbE

Tran et al.

#drugsincontext #hematology #ldl #lipidology #pharmacology #MedSky #PharmSky @medsky.social @me.pharmsky.app

www.drugsincontext.com/deferiprone-...

3D Protein Imaging

@proteinimaging.bsky.social

4 months ago

Here you can see a cryoEM structure of human Apolipoprotein B 100 bound to LDL receptor (PDB code: 9BDT)

Rendering by Francisco J. Enguita made with #ProteinImager

3dproteinimaging.com/protein-imag...

#SciArt #molecularart #apolipoprotein #cholesterol #membrane #receptor #LDL #cryoem