Model describing how daily rhythmic O-GlcNAc proteome integrates environmental and metabolic signals to regulate transcriptomic and physiological rhythms. Environmental cues signaling through the molecular clock and metabolic cues from feeding–fasting cycles regulate daily rhythms in the O-GlcNAc proteome. Rhythmic O-GlcNAcylation can directly shape daily rhythmicity in transcriptome and physiology. In addition, rhythmic O-GlcNAcylation can also interact with rhythmic phosphorylation. Different forms of crosstalk between O-GlcNAc proteome and phosphoproteome are shown in the middle box. The red solid arrows indicate the regulations described in this study, while the dashed arrow indicates regulations discovered by previous studies. Figure created using BioRender.com.
The liver #transcriptome is highly sensitive to metabolic cues. By characterizing nuclear protein #OGlcNAcylation in mouse #liver during the day, @joanna-chiu.bsky.social &co show how shifts in a nutrient-sensitive #PTM may shape transcriptional regulation @plosbiology.org 🧪 plos.io/3KuS7m1