Schwarbs on pace for a 162-homer season. Ring the bell. #Nof1
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#nof1
Latest posts tagged with #nof1 on Bluesky
Posts tagged #nof1
#statstab #471 Analysis Resources for N-of-1 research
Thoughts: Some cool and some questionable stuff, but a good place to start looking.
#Nof1 #analysis #resources #estimand #methods #sced #stats #smallsample #scd
www.nof1sced.org/analysis
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#RandomizedTrials in individual patients – #Nof1 #RCTs – provide the highest certainty evidence of treatment impact in an individual. The epitome of best clinical practice. This article gives a step by step for setting up and running an N of 1 trial.
pubmed.ncbi.nlm.nih.gov/3409138/
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Perfectly baked pumpkin pie cooling on a rack. Looks good enough to eat. 😆
It was a successful outcome for my substitute pie weights using a Pyrex bowl with some water. 🥳
The pie crust did stick to the foil a little bit when I pulled it off, so next time, I'll spritz it with some cooking oil spray.
Pumpkin pie for the win! 🥰
#PumpkinPie 🧁 #Nof1 #Baking #Research
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#statstab #412 Causal inference for N-of-1 trials
Thoughts: Only skimmed this, curious what the #causalinference ppl think of this.
#Nof1 #causalinference #ATE #effect #estimand #inference
arxiv.org/abs/2406.103...
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#statstab #411 Dynamic structural equation modeling [Hamaker et al]
Thoughts: Has a great explanation for analysis N-of-1 studies.
#Nof1 #bayesian #sem #modelling #tutorial #bookchapter
www.statmodel.com/download/Ham...
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#nof1 #breastcancer #physicalactivity #EMA
- 10/16 participants 📈 self-efficacy
- idiographic dynamic patterns identified
- significant self-efficacy 📈 could be independent of depressive or anxiety symptom
😎published in a diamond model journal😎
journals.shareok.org/singlecasejo...
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TW: Painful facial expressions
These 4 trials show a basic pattern of my response to C-tactile touch. EEG, ECG, and more soon. See thread for hypotheses!
Also, please excuse the very scientific Q-tip. I've...misplaced my Von Frey monofilaments! 😂
#BuildInPublic #Neurophysiology #Biosignals #Nof1
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#statstab #395 The n-of-1 randomized controlled trial: clinical usefulness
Thoughts: Could RCTs comprised of 1 participant be useful? Maybe! And more so than large sample observational studies.
#Nof1 #RCTs #causalinference #research #methods #clinical
pubmed.ncbi.nlm.nih.gov/2297206/
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A terminal window displays output from running a Node.js script (node build/scripts/demo.js) for a causal model used in the I-INSULA protocol. The causal model M is shown as a triple ⟨U, V, F⟩, where U is a set of external variables (like C-tactile, vestibular, thermal, and visual stimuli), V is a set of internal biosignal variables (like source-localized EEG and EMG), and F is a set of causal mechanisms represented as functions. A submodel Mx is also shown, where one function in F has been modified to return a constant value (e.g., 1) to simulate activity of an internal variable (in this example, posterior insular cortex activity) to test whether it is sufficient to causally explain downstream activity in the cingulate cortex or EMG muscle activity.
A screenshot of TypeScript code in a code editor, showing part of the StructuralCausalModel class implementation. The method toSubmodel takes a set of mechanism modifications (Fx), stores them in instance variables (currentF, currentFx), and performs causal mechanism overrides via doMechanismModifications(), replacing the function with a constant-returning one. The new submodel is then created in createSubmodel() and returned.
C-tactile touch (slow, gentle) is normally pleasant.
For me, it's painful (allodynia) and causes involuntary movements / vocalizations under certain conditions.
Hypothesis: C-tactile => #Insula => Cingulate => PAG => Motor
Here’s a partial #causal model to test!
#BuildInPublic #EEG #Nof1
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Screenshot of a TypeScript class named StructuralCausalModel implementing Judea Pearl’s formalism of a structural causal model. The class defines private readonly fields U, V, and F for external (exogenous) variables, internal (endogenous) variables, and causal mechanisms, respectively. It includes a static Create method, a toTriple method, and supporting interfaces for typing the causal model components. The code structure reflects a modular, type-safe design for executable causal modeling.
I’ve been building these graphs to show likely neuroanatomical pathways of my unexplained condition.
Tonight, I started building the causal engine to move from unexplained to explained.
I'm becoming a falsifiable model, one mechanism at a time.
#Neuroscience #Causality #EEG #Nof1 #BuildInPublic
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I'm grateful to the SFRR-E for the ECR Fellowship (@sfrre-ecr.bsky.social) which made the RedoxOne project a reality. Otherwise, it would still be an idea saved in the “future studies” word file!
#redox #antioxidants #exercise #nutrition #Nof1 #interindividual_variability #galway
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#statstab #329 Bayesian versus frequentist approaches in multilevel single-case designs: on power and type I error rate
Thoughts: An interesting project highlighting some benefits of #bayesian methods for #nof1 designs.
#stats #r #sced #mixedeffects
osf.io/k7b82/files/...
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#statstab #319 Small Sample Size Solutions [book]
Thoughts: This should just be the default text for psychologists, as most research fits the "small sample" label.
#smallsample #book #guide #bayesian #permutation #sem #metaanalysis #nof1 #missingdata
doi.org/10.4324/9780...
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#statstab #311 The analysis of continuous data from n-of-1 trials using paired cycles: a simple tutorial
Thoughts: @stephensenn.bsky.social shows how to treat multiple #nof1 studies as a meta-analysis.
#sced #nof1 #metaanalysis #tutorial #clinical
trialsjournal.biomedcentral.com/articles/10....
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10000% yes. #Dermatomyositis at 2 years old, in remission since 1972. But the havoc it wrecked has been super painful. And since survival rates were lower back then, I have never seen anyone (patient or doctor) who gets it #Nof1 or, frankly, seems to know what’s going on. And also pain scales suck.
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Deadline approaching - 21st March.
Join the International Collaborative Network for N-of-1 Trials and Single-Case Designs (ICN) Team! – Multiple volunteer opportunities available. More info here www.nof1sced.org/vacancies #nof1
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Personality psychology is getting personal: Advancing the field through personalisation.
Pleased to see this paper just published. We explore the need for personalised research methods (including #Nof1 methods) in psychology. Traditional methods often fall short because they assume what works for the ‘average’ person works for everyone -rarely true! journals.sagepub.com/doi/10.1177/...
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Just read this thought-provoking paper published in EJPP that explores the evolving debate between nomothetic & idiographic approaches in personality research. Was happy to see N-of-1 studies highlighted for their role in generating person-specific insights journals.sagepub.com/doi/abs/10.1... #nof1
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The words used in #radiology are similar to that of #design and how our words, build 🌎
#RSNA24 #Nof1
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Within the guidelines of ACR it even states that it may be appropriate to communicate rules directly to #patient
#RSNA24 #Nof1
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Interesting, when asked the room if there are laws required to report results to #patient, majority of room said 🤷🏾♂️
Yet, if you’re a breast #radiologist it’s standard practice.
#RSNA24 #Nof1
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The average hospital in the U.S. creates an average of 50 PB of data annually.
Yet, 90% of that data goes unused.
Missed opportunity for #patients & #physicians to deliver better care at the #Nof1
#RadSky #RSNA24
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Road to #RSNA24
This will be the most calm all week. Excited to learn, observe, and connect with others wanting to make an impact on #healthcare
#RadSky #Nof1
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See you soon my friend. It’s going to be a busy and exciting week. Learning from others at the #Nof1 during #RSNA24
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Evolution of Care: Solving Healthcare’s Supply Crisis Without Losing Our Soul
bit.ly/3Ot7xpC
#healthcare #Nof1 #ptexp
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#statstab #220 Small is beautiful: In defense of the small-N design
Thoughts: "high power and inferential validity of the small-N design, in contrast to the lower power and inferential indeterminacy of the large-N design"
#nof1 #sced #scd #smallsample
doi.org/10.3758/s134...
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