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Latest posts tagged with #stemcell on Bluesky

Posts tagged #stemcell

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Senescent Mesenchymal Stromal Cells Differentially Alter Adipogenesis in Adipose Tissue, Skeletal Muscle, and Bone Marrow Objective Aging alters mesenchymal stromal cell (MSC) function, leading to dysregulated adipogenesis across tissues through biased lineage commitment. Fat redistribution from adipose depots to skele...

Progenitor cells at the intersection of aging and adipose.

Researchers examined cells cultured from bone, muscle, and adipose to understand how these tissue-resident progenitors may contribute to fat deposition changes with induced senescence.
🧪 #CellBiology #StemCell

doi.org/10.1002/oby....

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Bio-protocol's new issue is now live! 🎉
bio-protocol.org/en/archive?v...

Check out the latest step-by-step protocols in various #LifeSciences fields.

#Biochemistry #CancerBiology #DevelopmentalBiology #Immunology #Neuroscience #PlantScience #StemCell

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A promotion for the 2026 ARVO+Genentech closing keynote in Denver, Colorado featuring a photo of the speaker, Sally Temple, PhD, Scientific Director at the Neural Stem Cell Institute. The event details are Thursday, May 7, from 10:15 to 11:30 am. Her presentation topic is “Modeling, Targeting and Healing: Stem Cell Strategies to Combat Neurodegeneration in the Brain and Eye.” The ARVO.org/keynotes webpage is listed for more information.

A promotion for the 2026 ARVO+Genentech closing keynote in Denver, Colorado featuring a photo of the speaker, Sally Temple, PhD, Scientific Director at the Neural Stem Cell Institute. The event details are Thursday, May 7, from 10:15 to 11:30 am. Her presentation topic is “Modeling, Targeting and Healing: Stem Cell Strategies to Combat Neurodegeneration in the Brain and Eye.” The ARVO.org/keynotes webpage is listed for more information.

Explore #StemCell strategies to combat #neurodegeneration in the brain and eye with @arvoinfo.bsky.social+@genentech.bsky.social closing keynote Sally Temple, PhD (Neural Stem Cell Institute). Don't miss it on May 7 at #ARVO2026. Learn more: https://bit.ly/41Eg6EC

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Phase I/II Trials of Donor Regulatory T Cells for the Treatment of Steroid-Refractory Chronic Graft versus Host Disease Chronic Graft versus Host Disease (cGVHD) remains a major hurdle to the success of hematopoietic stem cell transplantation (HSCT), directly impacting patient morbidity and mortality. Impaired Treg recovery in patients with cGVHD has led to clinical studies aiming to increase peripheral Treg numbers. We performed Phase I dose escalation clinical trials, testing the feasibility and safety of using freshly isolated donor-derived Treg infusions in steroid-refractory/dependent cGVHD. The Phase I was extended to a preliminary Phase II trial, resulting in a total of 33 treated patients. We report that Treg purification from donor leukapheresis using CliniMACS were feasible and that Treg infusions were safe. Importantly, Treg infusions resulted in improved symptoms, particularly at higher Treg doses. Global responses were observed in 71% of patients, and 52% of patients had at least a 2-point improvement in the cGVHD severity scale. Furthermore, improvement in cGVHD symptoms resulted in reductions in corticosteroids, ruxolitinib and mycophenolate (MMF) in 58%, 83% and 33% of patients, respectively, while calcineurin inhibitors were discontinued in 75% of patients. Exploratory analyses revealed the detection of infused Treg clonotypes up to 12 months post-infusion and suggest increased Treg numbers in circulation. We observed increases in serum levels of IL-7, IFN-g, and decreases in sCD13 and ST2 over time, which were not statistically significant following adjustment for multiple comparisons. Although these studies were not powered to assess efficacy, they suggest potential therapeutic benefits of donor-derived Treg in cGVHD treatment and highlight the need for larger Phase II clinical trials. NCT02385019 NCT03683498 (clinicaltrials.gov).

🔗 #StemCell Evidence link to:
Phase I/II Trials of Donor Regulatory T Cells for the Treatment of Steroid-Refractory Chronic Graft versus Host Disease
by Soares et al.
www.stemcellevidence.com/alerts/artic...
#MedSky

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Organoid models for infectious diseases Editors welcome the submission of primary research Articles focusing on recent advances of stem cell-based organoid models for studying infectious diseases, ...

#CallForPapers! 📣 @commsbio.nature.com and @natcomms.nature.com are seeking primary research articles from authors who use stem cell-based #organoid models for studying #InfectiousDisease.

Submit by December 21!

www.nature.com/collections/...

#assembloid #stemcell #IDsky #Virosky #Microsky

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Regenerative medicine has been shown to support patients with varying degrees of back pain, enabling them to achieve gradual and meaningful improvement over time.
#glorywellnessclinics #backpainrelief #regenerativemedicine #lagosabuja #stemcell #healingnaturally

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My favorite weird & not-so-weird but cool science pictures from 16 years of The Niche: Part 1 - The Niche Professor discusses his favorite weird and not-so-weird science pictures from 15 years of The Niche including some related to stem cells.

My favorite weird & not-so-weird but cool science pictures from 16 years of The Niche: Part 1 ipscell.com/2026/04/my-f... #stemcells #stemcell including this flesh-faced "robot"

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Regenerative medicine at its peak now available in Lagos and Abuja.
As regenerative care continues to evolve globally, we bring advanced, non-invasive therapies designed to support the body’s natural healing process. Trusted by patients, guided by medical expertise. #trending #viral #abuja #stemcell

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Do you ever have trouble picking which conference to attend as a #DevBio or #StemCell scientist? The Node features Meeting Reports, with first-hand accounts of conferences and meetings, which can help you choose.

thenode.biologists.com/category/mee...

#AcademicConferences

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Learn, Swab, Save Lives Gift of Life Marrow Registry explains why blood stem cell and bone marrow donors are needed to help save patients; lives, and how to join the marrow registry by completing a cheek swab kit.

Learn, Swab, Save Lives Gift of Life to so many! Get on #Stemcell Registry which isn't hard to do! #SWABFORMAX Juan Uribe urgently seeking donor for his son, Max, rare, life-threatening blood disorder requiring a transplant! Hopefully Opt in at your Dr's visit, ER?! share.google/TcS2SDLqxWAY...

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Weekly reads: Gattaca stack, animal sacks, custom iPS cells, ImmunityBio FDA warning, mouse cloning limit - The Niche Professor discusses regenerative news: Gattaca stack, animal sacks, custom iPS cells, ImmunityBio FDA warning, mouse cloning limit

ICYMI: Weekly #stemcell & #regenerative reads: Gattaca stack, animal sacks, custom iPS cells (is it worth $40K+?), ImmunityBio FDA warning, mouse cloning limit finally reached ipscell.com/2026/03/week... #stemcells

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Weekly reads: Gattaca stack, animal sacks, custom iPS cells, ImmunityBio FDA warning, mouse cloning limit - The Niche Professor discusses regenerative news: Gattaca stack, animal sacks, custom iPS cells, ImmunityBio FDA warning, mouse cloning limit

Weekly #regenerative reads: Gattaca stack, animal sacks, custom iPS cells, ImmunityBio FDA warning, mouse cloning limit ipscell.com/2026/03/week... #stemcells #stemcell

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Too fast, too short: mini-hearts, genome editing, and the new biology of sudden cardiac death This editorial refers to ‘SLC4A3-related short QT syndrome assessed in human induced pluripotent stem cell-derived cardiomyocytes: mechanisms of ventricula

Thanks to the #EuropeanHeartJournal for inviting me to write an #editorial on the important topic and article on #SuddenCardiacDeath 🫀

academic.oup.com/eurheartj/ad...

@escardio.bsky.social #arrhythmia #fibrillation #organoid #crispr #stemcell #SQTS

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Photo of Hans Clevers

Photo of Hans Clevers

Our new Special Issue has launched with a fascinating interview with @hansclevers.bsky.social where he discusses the future of #organoid and #StemCell research

"My personal opinion is that the strength of the organoids is their simplicity."

doi.org/10.1242/dmm....
@hubrechtinstitute.bsky.social

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Effects of human embryonic stem cell–derived Schwann cells for nerve regeneration after facial nerve injury
doi.org/10.1177/0963...
#stemcell #schwann #nerve #regeneration
@journals.sagepub.com

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Image cytometry differentiates CD34+ and CD133+ profiles of very small embryonic-like stem cells
doi.org/10.1177/0963...
#stemcell
@journals.sagepub.com

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Advancing the Battle against Cystic Fibrosis: Stem Cell and Gene Therapy Insights

Advancing the Battle against Cystic Fibrosis: Stem Cell and Gene Therapy Insights

This review examines #CysticFibrosis (CF) pathophysiology and the emerging role of #StemCell and #GeneTherapies, highlighting how these strategies could redefine CF management and improve #PatientOutcomes. #medsky

Full article here: doi.org/10.1007/s115...

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Dad’s social media plea to save his son’s life goes viral Juan Uribe said he left his job last year to focus his efforts on his son Max.

www.aol.com/dad-issues-u...

#stemcell #transplant

Save a life! Sign up to donate.

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StemRenu | #1 High-Performance Stem Cell Technology StemRenu is an advanced antioxidant containing signalling peptides, activating direct adult stem cells to promoting health, harnessing power of cell protection.

StemRenu a supercharged formula works at cellular level supporting health, restores body to balanced state. bit.ly/1YlOdbI #Stemcell

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How do cell lineages evolve, and how does that shape trait evolution?

Join our symposium Tracing Evolution Through Cell Lineages (Plön, 12–14 October). Hear perspectives from leading scientists and contribute with your own.
Read more at: bit.ly/3PCSkpQ

#EvoDevo #DevBio #StemCell #evolution

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新しい美容体験!凍結幹細胞培養上清液の施術メニューが登場 2026年4月1日より、3つのサロンで凍結幹細胞培養上清液を使用した施術メニューが開始。美しさを体感できる新しい美容体験をご紹介します。

新しい美容体験!凍結幹細胞培養上清液の施術メニューが登場 #東京都 #中央区 #アートネイチャー #幹細胞 #STEMCELL

2026年4月1日より、3つのサロンで凍結幹細胞培養上清液を使用した施術メニューが開始。美しさを体感できる新しい美容体験をご紹介します。

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Weekly reads: the thymus and aging, Aspen upbeat 1 year data, paired organoids - The Niche Stem cell biologist discusses recent research including on Aspen encouraging data at 1 year, thymus and aging, paired organoids.

Weekly reads: intriguing links between the thymus and aging, Aspen upbeat 1 year data on #stemcells for Parkinson's, paired organoids, more ipscell.com/2026/03/week... #stemcell

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Insights from derivation of human IPS #stemcell derived islet-like or off-target enterochromaffin (EC)-like cells in the pancreas #diabetes www.nature.com/articles/s41...

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StemRenu | #1 High-Performance Stem Cell Technology StemRenu is an advanced antioxidant containing signalling peptides, activating direct adult stem cells to promoting health, harnessing power of cell protection.

StemRenu provides growth factors, amino acids, biological sugars, minerals & antioxidants at cellular level. bit.ly/1YlOdbI #Stemcell

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What is in vivo reprogramming, its potential pros & cons? - The Niche Stem cell biologist discusses in vivo reprogramming, its pros and cons, and the potential applications in regenerative medicine.

What is in vivo reprogramming, its potential pros & cons? ipscell.com/2025/10/what... Why do people & biotechs want very much to only do partial in vivo reprogramming in humans? #stemcells #stemcell

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Illustration of a cell undergoing division, showing two nuclei forming within a translucent cell membrane.

Illustration of a cell undergoing division, showing two nuclei forming within a translucent cell membrane.

Opinion piece: The #FDA must regulate #StemCell therapies to mitigate risks to patients and the public. In PNAS Front Matter: https://ow.ly/4cVk50Ywta2

#StemCellTherapy #HHS #Evidence-basedMedicine #AdultStemCells #EmbryonicStemCells

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Hi from the new Community Manager - the Node An introduction to the Node's new Community Manager, Andrea Murillo

Hi from the new Community Manager

The Node welcomes Andrea Murillo as the new Community Manager. Here, @andreamurillo.bsky.social introduces herself to our #DevBio and #StemCell communities.

thenode.biologists.com/hi-from-the-...

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Schematics showing the mechanism of how ERK activity coordinates ME differentiation and cell cycle. When the pluripotent stem cells (PSCs) differentiate towards mesendoderm (ME), ERK activity increases. Multiple morphogens controlling ME differentiation contribute to the increase of ERK activity, which also quantitatively modulate ERK activity. Increased ERK activity promotes efficient TBXT expression without dramatic remodeling of cell cycle during ME differentiation. This is because the ranges of ERK activity that promote cell cycle progression and TBXT protein production are distinct. The distinct ERK activity response ranges are reflective of gene-specific variations in sensitivity to ERK regulation at both the transcriptional and translational levels. Created with the help of BioRender. Liang, H. (2025)

Schematics showing the mechanism of how ERK activity coordinates ME differentiation and cell cycle. When the pluripotent stem cells (PSCs) differentiate towards mesendoderm (ME), ERK activity increases. Multiple morphogens controlling ME differentiation contribute to the increase of ERK activity, which also quantitatively modulate ERK activity. Increased ERK activity promotes efficient TBXT expression without dramatic remodeling of cell cycle during ME differentiation. This is because the ranges of ERK activity that promote cell cycle progression and TBXT protein production are distinct. The distinct ERK activity response ranges are reflective of gene-specific variations in sensitivity to ERK regulation at both the transcriptional and translational levels. Created with the help of BioRender. Liang, H. (2025)

ERK regulates both proliferation & lineage specification during #embryo development, but how? This study shows that ERK levels modulate human pluripotent #StemCell differentiation into mesendoderm by fine-tuning its differentiation potential & cell division speed @plosbiology.org 🧪 plos.io/4seESa5

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Schematics showing the mechanism of how ERK activity coordinates ME differentiation and cell cycle. When the pluripotent stem cells (PSCs) differentiate towards mesendoderm (ME), ERK activity increases. Multiple morphogens controlling ME differentiation contribute to the increase of ERK activity, which also quantitatively modulate ERK activity. Increased ERK activity promotes efficient TBXT expression without dramatic remodeling of cell cycle during ME differentiation. This is because the ranges of ERK activity that promote cell cycle progression and TBXT protein production are distinct. The distinct ERK activity response ranges are reflective of gene-specific variations in sensitivity to ERK regulation at both the transcriptional and translational levels. Created with the help of BioRender. Liang, H. (2025)

Schematics showing the mechanism of how ERK activity coordinates ME differentiation and cell cycle. When the pluripotent stem cells (PSCs) differentiate towards mesendoderm (ME), ERK activity increases. Multiple morphogens controlling ME differentiation contribute to the increase of ERK activity, which also quantitatively modulate ERK activity. Increased ERK activity promotes efficient TBXT expression without dramatic remodeling of cell cycle during ME differentiation. This is because the ranges of ERK activity that promote cell cycle progression and TBXT protein production are distinct. The distinct ERK activity response ranges are reflective of gene-specific variations in sensitivity to ERK regulation at both the transcriptional and translational levels. Created with the help of BioRender. Liang, H. (2025)

ERK regulates both proliferation & lineage specification during #embryo development, but how? This study shows that ERK levels modulate human pluripotent #StemCell differentiation into mesendoderm by fine-tuning its differentiation potential & cell division speed @plosbiology.org 🧪 plos.io/4seESa5

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Schematics showing the mechanism of how ERK activity coordinates ME differentiation and cell cycle. When the pluripotent stem cells (PSCs) differentiate towards mesendoderm (ME), ERK activity increases. Multiple morphogens controlling ME differentiation contribute to the increase of ERK activity, which also quantitatively modulate ERK activity. Increased ERK activity promotes efficient TBXT expression without dramatic remodeling of cell cycle during ME differentiation. This is because the ranges of ERK activity that promote cell cycle progression and TBXT protein production are distinct. The distinct ERK activity response ranges are reflective of gene-specific variations in sensitivity to ERK regulation at both the transcriptional and translational levels. Created with the help of BioRender. Liang, H. (2025)

Schematics showing the mechanism of how ERK activity coordinates ME differentiation and cell cycle. When the pluripotent stem cells (PSCs) differentiate towards mesendoderm (ME), ERK activity increases. Multiple morphogens controlling ME differentiation contribute to the increase of ERK activity, which also quantitatively modulate ERK activity. Increased ERK activity promotes efficient TBXT expression without dramatic remodeling of cell cycle during ME differentiation. This is because the ranges of ERK activity that promote cell cycle progression and TBXT protein production are distinct. The distinct ERK activity response ranges are reflective of gene-specific variations in sensitivity to ERK regulation at both the transcriptional and translational levels. Created with the help of BioRender. Liang, H. (2025)

ERK regulates both proliferation & lineage specification during #embryo development, but how? This study shows that ERK levels modulate human pluripotent #StemCell differentiation into mesendoderm by fine-tuning its differentiation potential & cell division speed @plosbiology.org 🧪 plos.io/4seESa5

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