Latest posts tagged with #mtDNA on Bluesky
Researchers recently developed a new system called #MitoPerturb-Seq that can systematically map cellular stress responses associated with specific genes related to #mtDNA maintenance.
Read more: https://bit.ly/4e54hib
#RareDisease #TK2d #MedSky
Short-chain acyl-CoA dehydrogenase promotes antitumor immunity in #ColorectalCancer by initiating #mtDNA demethylation and cytosolic leakage, thereby activating the cGAS–STING pathway, enhancing immune surveillance.
#STTT #OpenAccess: doi.org/10.1038/s413...
Below is a rigorous, explanation that does not pathologize any race, avoids racial essentialism, instead examines systems,
historical conditions, and #psychological mechanisms of the #Savage #Fraud called #whiteness in an era of👉 #mtDNA Science
theorionblogown.blogspot.com/2025/11/my-q...
#biology
We found that physiological and reversible pearling acts simultaneously as a nucleoid spacing ruler and disaggregation mechanism, elegantly establishing the fundamental distribution of #mtDNA nucleoids. [4/6]
Our paper is now out in Science! Super excited to share our discovery that #mitochondria #pearling is the elusive mechanism driving the regular distribution and inheritance of #mtDNA nucleoids 🧬 [1/6]
Report on loss of diversity in #mtDNA lineages of #Neanderthals around 65,000 years ago
archaeology.org/news/2026/03/30/study-tr...
Interested in Pre-clinical Mitochondrial Disease Models?
MRC MitoCluster is delivering a session this May at Queen Square Advances in Mitochondrial Medicine 2026. Register now to join!
#MitochondrialDisease #MitochondrialMedicine #mtDNA #GeneticEngineering #PreclinicalResearch #RareDisease
Sterling, Zwonitzer & Havird explored the relationship between mtDNA evolution and species' lifespans, showing long-lived vertebrates showed reduced synonymous and nonsynonymous substitution rates, suggesting lower mtDNA mutation.
🔗 doi.org/10.1093/gbe/...
#genome #evolution #mtDNA
Neikirk et al. explore how #mitochondrial epigenetics drives aging, cardiovascular disease, neurodegeneration, and cancer, highlighting new therapeutic avenues and transgenerational effects. doi.org/10.4103/AGIN... #Epigenetics #Aging #Mitoepigenetics #mtDNA #Longevity #MedSky #neuroskyence
#ACMGMtg26: Researchers noted that TK1 may partially compensate for #TK2 deficiency in vitro, although its contribution to #mtDNA maintenance in this system remains unclear. @theacmg.bsky.social
Read more: https://bit.ly/4t0VcLP
#RareDisease #TK2d #MedSky
GBE | Evidence of Relaxed Selection in the Mitochondrial Genomes of Phototrophic Paulinella Lineages
Han et al. studied phototrophic Paulinella amoeba, suggesting that primary endosymbiosis may have left a detectable footprint in host mitochondrial genomes.
🔗 doi.org/10.1093/gbe/evag052
#genome #evolution #mtDNA
@bhattacharyalab.bsky.social
Straight-tusked #elephants once roamed across #Eurasia, but one lineage became stranded in Japan?! 🐘🧬 Ancient #mtDNA reveals Palaeoloxodon naumanni as an early-diverging lineage that survived in island isolation.
doi.org/10.1016/j.is...
#MetagenomicsMonday #SPAAM #aDNA #palaeogenetics #ancientDNA
We have officially launched our new lab website. 🥳
The site includes the automated literature curation on #mtDNA quality control and copy number regulation, which will appear on Mondays and Thursdays. Listen to the latest #NotebookLM generated podcast.
🧬 Explore the new site: osman-lab.de
This review highlights #mtDNA leakage as a driver of #CellularSenescence and the SASP, activating cGAS–STING, #TLR9, and #NLRP3, while exploring strategies to block release or downstream sensing to combat #AgingRelatedDiseases.
#OpenAccess: doi.org/10.1016/j.ge...
MBE | Mammalian mitochondrial DNA accumulates insertions and deletions with age in energetically demanding tissues
@edmundotogo.bsky.social et al. studied de novo indel mtDNA mutations across multiple age groups in three mammalian species, showing that indels accumulate rapidly with age in somatic tissues with high energetic demand or high proliferation.
🔗 doi.org/10.1093/molb...
#evobio #molbio #mtDNA
The study discusses how the findings challenge the one specimen–one barcode premise, and the implications of sequence divergence on #metabarcoding-based assessments.
Image credit: Niina Kiljunen and Marko Mutanen.
#COI #mtDNA
GBE Highlight: The “Wild West” of Mitochondrial Genome Evolution in the Gastrotricha
February's article on mitogenome evolution in the Gastrotricha is the focus of this month's GBE Highlight.
Highlight: The “Wild West” of Mitochondrial Genome Evolution in the Gastrotricha
🔗 doi.org/10.1093/gbe/evag019
#genome #evolution #mtDNA
Early Bird extended to Feb 27, 2026! Final chance to get the preferential rate.
🔗Register now: www.euromit2026.eu/registration/
EUROMIT 2026 – May 31–June 4, Angers - France
#EUROMIT2026 #MitochondrialDisease #mtDNA #mitochondria @chuangers.bsky.social @univangers.bsky.social
STING drives pressure overload–induced #CardiacFibrosis and remodeling by promoting #inflammation, oxidative stress, and fibroblast activation, while #mitophagy limits cytosolic #mtDNA and STING signaling. #HeartFailure
#OpenAccess: doi.org/10.1016/j.ge...
Promotional image announcing the upcoming deadline for the Early Bird rate for EUROMIT 2026. At the top, the text reads “Take advantage before February 17, 2026!”. In the center, two tilted green shapes display the words “Early Bird” and “Rate”. The background features green, mitochondria‑like patterns on a black backdrop. At the bottom, a green band contains the text “EUROMIT 2026
Only a few days left to get the Early Bird rate!
Early Bird registration for EUROMIT 2026 ends on 17 February 2026
👉 Registration : lnkd.in/ecsTM5Gr
👉 Submit your abstract : lnkd.in/ejCS3e4t
#EUROMIT2026 #MitochondrialDisease #mtDNA #mitochondria @chuangers.bsky.social @univangers.bsky.social
GBE | From Rigid Order to Radical Variation: Mitogenome Evolution in the Main Lineages of a Lesser-Known Animal Phylum (Gastrotricha)
Kosakyan et al. sequenced mitogenomes of species from the two main lineages of the Gastrotricha; they found stable mitogenomes in the mostly freshwater Chaetonotida, but a dynamic pattern in the the marine Macrodasyida.
🔗 doi.org/10.1093/gbe/evag001
#genome #evolution #mtDNA
Excellent tool! We’ve been testing it all week and it’s already been great for catching every paper. The format makes it much easier to engage with the full daily #mtDNA literature than a standard search! 🧬 Great job @osman-lab.bsky.social
Square, neon-colored illustration announcing a “Daily Briefing” on mtDNA, showing mitochondria, DNA, AI icons, literature stacks, exercise symbols, and a bar graph, in a futuristic purple-pink style.
🧬 Introducing the #mtDNA Lab Intel Pipeline!
Our system daily scans PubMed and bioRxiv to bring you: 📄 #Gemini generated Daily Dossiers (PDF) and 🎙️ #NotebookLM generated Podcasts with a focus on #mtDNA-QC and #mtDNA-copy-number
📂 Full Archive:
drive.google.com/drive/folder...
Primary mitochondrial diseases (#PMDs), including thymidine kinase 2 deficiency (#TK2d), may be driven not only by bioenergetic failure but also by activation of innate immunity triggered by mitochondrial DNA release (#mtDNA).
Read here: https://bit.ly/4qlWwao
#RareDisease #MedSky
Genome Biology and Evolution | February 2026 cover
The cover of February's issue of Genome Biology and Evolution features the work of Kosakyan et al. on the evolution of mitochondrial genomes in the Gastrotricha.
🔗 doi.org/10.1093/gbe/evag001
#genome #evolution #mtDNA
📢 New update on our website!
👉Don't forget : early‑bird rates are available until Februray, 17 !!
👉 : www.euromit2026.eu/article/book...
#EUROMIT2026 #MitochondrialDisease #mtDNA #mitochondria @chuangers.bsky.social @univangers.bsky.social
This #STTT study provides mechanistic insights into how arginase1 regulates mitochondrial cristae remodeling and #mtDNA release, triggering the cGAS-STING pathway and #PANoptosis during ischemic/hypoxic #VascularDysfunction.
#OpenAccess: doi.org/10.1038/s413...
Dive into our review of Family Tree DNA!🧬Learn how to trace your ancient haplogroups and use their powerful tools to break genealogical brick walls! → tinyurl.com/y9wejdrc
#FamilyTreeDNA #FTDNA #Genealogy #FamilyHistory #DNATesting #YDNA #MTDNA #Ancestry #GeneticGenealogy #EchoesOfKin
Our new paper is out 🎉 in @narjournal.bsky.social
A fascinating complex composed of Mrx6, Mam33, and Pim1 controls #mtDNA copy number by regulating Lon-dependent substrate turnover in #yeast.
Congrats to @simonrecyclable.bsky.social, all co-authors and collaborators!
academic.oup.com/nar/article/...
This review describes the relationship between #mtDNA integrity and #CardiacFunction, the associated regulatory pathways and the mechanisms driving #MitochondrialDysfunction and #Ischemia/#Reperfusion-induced cardiomyocyte injury. #medsky
#OpenAccess: doi.org/10.1016/j.ge...
![4Qua Of Orion [ General NobuNaga Version ]](https://cdn.bsky.app/img/avatar/plain/did:plc:fgiqkkrmaycusjocndaqrpz3/bafkreibo4nfpi7oitgitlxkwrin5f6nxubfzif6kiinbaxw2zn2ivpyy4m)
